Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0025362 (
mental retardation
)
15,878
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
5-Fluoro-2'-deoxyuridine
(FUdR) was found to be highly effective in inducing the heritable fragile site on Xq28 associated with
mental retardation
. Lymphocytes from two affected males manifested the fragile site in 30 to 40% of the mitoses when grown in the presence of FUdR. This observation suggests that depletion of the dTMP pool via thymidylate synthetase inhibition is responsible for the expression of the heritable fragile site on Xq28.
...
PMID:5-Fluoro-2'-deoxyuridine induction of the fragile site on Xq28 associated with X linked mental retardation. 646 Jan 4
