Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0025362 (mental retardation)
 15,878 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of neuroleptic malignant syndrome is described in a 37-year-old man with mental retardation, hypomania and a history of recent hepatitis B infection. The NMS is reviewed and the potential importance of this iatrogenic emergency in mental handicap practice is emphasized.
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PMID:Neuroleptic malignant syndrome with hypomania and mental retardation. 276 43

The relation between psychiatric symptoms and different types of challenging behaviour in adults with mental retardation was investigated, using an instrument designed for use by non-specialist informants. A sample of 165 persons with mental retardation was surveyed for the presence of psychiatric symptoms, level of mental retardation, and self-injurious and other types of challenging behaviour. Challenging behaviour was associated with increased prevalence of psychiatric symptoms, especially anxiety and psychosis, less with hypomania, and not with depression. No association between anxiety and self-injurious behaviour was found. An association between psychiatric symptoms and challenging behaviour on a group level is an initial step towards understanding causes of challenging behaviour. Issues remain, like how causation takes place on an individual level, and the nature of psychiatric disorders in persons with severe and profound mental retardation.
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PMID:Prevalence of psychiatric symptoms in adults with mental retardation and challenging behaviour. 1295 Nov 30

A 55-year-old man with congenital hemiparesis of the right side, three episodes of generalised tonic-clonic seizure at 16 years of age, and two episodes of severe depression and two episodes of hypomania in the past, presented with severe depression with psychotic symptoms. Computed tomography of the brain showed a grey matter-lined cerebrospinal fluid-filled cleft in the left cerebral hemisphere, involving the temporoparietal region. He was diagnosed to have bipolar II disorder, and was currently severely depressed with psychotic symptoms and schizencephaly. He improved with sodium valproate 1,000 mg/day, quetiapine 450 mg/day and escitalopram 20 mg/day after three weeks without any emergent side effects, and was maintaining well at three months follow-up. Although uncommon, schizencephaly may be considered as one of the differentials in cases of bipolar disorder along with congenital hemiparesis, mental retardation and/or seizures; and neuroimaging should be done to confirm the diagnosis.
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PMID:Schizencephaly associated with bipolar II disorder. 1929 19