Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0025362 (
mental retardation
)
15,878
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In a search for genes involved in X-linked
mental retardation
we have analyzed the expression pattern and genomic structure of human MAGED2. This gene is a member of a new defined
MAGE-D
cluster in Xp11.2, a hot spot for X-linked
mental retardation
. Rat and mouse orthologues have been isolated. In contrast to the genes of the MAGE-A, MAGE- B and MAGE-C clusters, MAGED2 is expressed ubiquitously. High expression was detected in specific brain regions and in the interstitium of testes. Five SNPs in the coding region of human MAGED2 were characterized and their allele frequencies determined in a German and Turkish population.
...
PMID:Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues. 1185 87
