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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This lengthy discussion of possible associations between both endogenous and exogenous estrogens and progestins to occurrence of human cancers begins by discussing endogenous metabolism of the 2 sex steroid types. For example, the endogenous production of estrogen is associated with anovulation and endometrial cancer, although clearly other risk factors are associated with these diseases, and breast cancer, which account for some or all of the sex hormones apparent carcinogenic effect. Also discussed are the modulating effects of estriol on response of the breast and endometrium to estradiol and estrogens, and the modulating effects of androgens on development of breast cancer. The bulk of the monograph concerns summaries of data on the correlations of exogenous sex hormones and human cancers. Attention is also paid to the use of exogenous sex hormones for treatments of human cancers. Estrogens have been used to treat endometrial cancer, breast cancer, and benign breast disease. Side effects of hormonal contraception discussed include gross and microscopic changes in the breast, benign breast disease, and breast cancer; in the uterus, exogenous hormonal contraception is associated with neoplastic changes in the cervix, cervical neoplasia, endometrial cancer, trophoblastic tumors, and uterine fibroids. Ovarian effects include nonneoplastic and benign lesions and ovarian cancers. Oral contraception may also correlate with incidences of pituitary and melanoma malignancies. Liver effects include both benign neoplasms and malignant tumors.
IARC Monogr Eval Carcinog Risk Chem Hum 1979 Dec
PMID:Oestrogens and progestins in relation to human cancer. 39 83

A soluble fraction of particulate glucan was prepared and evaluated for its anti-tumor and anti-bacterial activity. Thin-layer chromatographic analysis indicated that the soluble preparation was composed of a variety of polyglucoses. Intravenous administration of soluble or particulate glucan resulted in significant reductions in the growth of a syngeneic anaplastic mammary carcinoma and melanoma B16. Survival data demonstrated that intravenous administration of soluble or particulate glucan prolonged survival of A/J and C57BL/6J mice with subcutaneous tumor implants. As regards to bacterial infections, soluble and particulate glucan decreased renal necrosis in S. aureus challenged mice as compared to control mice. Although the exact nature of the active soluble fraction(s) of glucan remains to be delineated, these studies demonstrate that a soluble glucan preparation exhibits significant anti-tumor and anti-staphylococcal activity. The active soluble fraction of particulate glucan may be preferable to particulate glucan in view of the inherent ease of parenteral administration.
Int J Cancer 1979 Dec 15
PMID:Comparative tumor-inhibitory and anti-bacterial activity of soluble and particulate glucan. 39 98

Murine melanoma cells provide an excellent system for studying the proposed role of nuclear nonhistone proteins (NHP's) as regulators of gene expression. Cloudman mouse melanoma cells (S91, NCTC 3960, CCL 53), grown in culture, are normally lightly pigmented, but in the presence of melanocyte stimulating hormone (MSH) show a large increase in melanin content. Cells were grown in medium with and withoug MSH and labeled with either 14C- or 3H-leucine, respectively. Following 48 hr of incubation, the cells were harvested, combined, and nuclei isolated. The NHPs were extracted from these nuclei in a series of steps which yielded 4 major fractions. Each fraction was further separated on DEAE cellulose columns into a total of 40 subfractions, each of which was electrophoresed on SDS gels. Each gel was sliced and counted and the 14C/3H ratio was determined for each slice. A number of differences in 14C/3H ratios were observed between the NHPs isolated from MSH-treated and control cells which reflect changes in the synthesis and/or transport of NHPs in MSH-treated cells.
J Invest Dermatol 1977 Dec
PMID:Nuclear nonhistone proteins in murine melanoma cells: II. changes following exposure to MSH. 41 35

Sinclair swine melanoma usually regresses in vivo. In the present study, swine melanoma cells were adapted to long-term growth in culture. The morphology of cultured melanoma cells ranged from dendritic to cuboidal, similar to that described for human melanoma cells. Doubling times of the swine melanoma cells were also similar to those of human melanoma cells in vitro. 3,4-Dihydroxy-L-phenylalanine oxidase-positive cells were detected by light microscopy, and melanin and premelanosomes were detected by electron microscopy. Cell cultures could be propagated from progressing, partially regressed, and primary cutaneous lesions, as well as from visceral metastases. Thus, it appears that, under these cell culture conditions, Sinclair swine melanoma cells can be adapted to prolonged growth in vitro.
Cancer Res 1979 Dec
PMID:Adaptation of Sinclair swine melanoma cells to long-term growth in vitro. 49 21

Criteria for the early recognition of malignant melanoma include appreciation of variegation in color and irregularity of lesion border and pigment pattern. Application of these criteria should result in the diagnosis of cutaneous melanoma in its premetastatic surgically curable phase.
JAMA 1979 Dec 21
PMID:Early recognition of cutaneous melanoma. 50 93

Several in vitro properties of two variant cell lines of the B16 melanoma (B16-F10 and B16-BL6) with markedly different spontaneous metastatic behavior were examined. The two cell lines were compared with regard to their in vitro growth rate, ability to migrate, ability to adhere to a variety of substrata, detachment rates, production of plasminogen activator, and cell surface proteins as determined by lactoperoxidase-catalyzed iodination. Growth rates in vitro, attachment rates, and qualitative patterns of cell surface proteins were almost identical. B16-F10 cells (the less spontaneously metastatic line) produced greater amounts of plasminogen activator, were more motile in vitro, and detached more readily from plastic than the more invasive B16-BL6 cells. The study of tumor cell variants, selected for different biologic behavior, is a valuable approach to the elucidation of those mechanisms responsible for their malignant activity.
Am J Pathol 1979 Dec
PMID:The selection and characterization of an invasive variant of the B16 melanoma. 50 92

We encountered inverted papilloma of the conjunctiva in three cases. To the best of our knowledge, this tumor, which typically involves the nose, paranasal sinuses, and lacrimal sac, has not been described previously in the conjunctiva. Two of the tumors occurred as purely inverted lesions of the inner canthal region )caruncle and plica) and the third as a mixed inverted-exophytic papilloma over the tarsus. Melanotic pigmentation in one of the lesions was clinically confused with malignant melanoma. Because of the high incidence of recurrence of these tumors in the sinuses and lacrimal sac, and their unknown biologic behavior in the conjunctiva, inverted papillomas should be removed completely and the patients carefully observed.
Am J Ophthalmol 1979 Dec
PMID:Inverted papilloma of the conjunctiva. 51 11

The results of liver, bone, and brain scans in 84 patients with recurrent or metastatic malignant melanoma were reviewed. The liver scan was initially positive in 18% (14/78) and ultimately in 32% (25/78). Serum alkaline phosphatase and lactic dehydrogenase were elevated in 92%. These patients ultimately developed positive liver scans, while convincing hepatomegaly was noted in only 44%. Bone scans were eventually positive in 33% (16/49), all of whom had pain. Brain scans were positive in 15% (10/65), all of whom had CNS symptoms. In asymptomatic patients, bone and brain scans only rarely disclosed occult lesions.
Clin Nucl Med 1979 Dec
PMID:Radionuclide scanning in patients with advanced malignant melanoma. 52 90

Data on cancer incidence in Israel have been collected by the Israel Cancer Registry since 1960. Overall incidence patterns are similar to those observed in other "Westernized" countries. In the total Jewish population, lung cancer accounts for one in seven cancers in males and breast cancer, for one in four cancers in females. The main time trends are: a decrease in stomach cancer, a halt in the increase of male lung cancer and a continuing rise for female lung cancer, female breast cancer, cancer of the colon and rectum, and malignant melanoma. Cancer of the uterine cervix may be on the rise in Israel-born women. The relatively high incidence of cancer of the esophagus in immigrants from Iran and Yemen and of cancer of the nasopharynx in immigrants from North Africa probably reflect incidence patterns in their countries of origin.
Isr J Med Sci 1979 Dec
PMID:Cancer patterns in Israel: selected aspects. 52 89

Three cases of malignant melanoma resembling spindle and epithelioid cell nevus histologically are presented. Lesions having histologic features of spindle and epithelioid cell nevus (Spitz nevus or juvenile melanoma) at or after puberty should be regarded with caution, particularly when they are heavily melanized. Such lesions are in a histologic "gray zone" and may be malignant.
Arch Dermatol 1979 Dec
PMID:Melanoma resembling spindle and epithelioid cell nevus. 53 85


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