Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In human tumor tissues of different degrees of differentiation--nevus-cell-nevus, basalioma, malign melanoma--the cAMP and cGMP content was determined and compared with the corresponding normal values. It is demonstrated that the quotient of the cAMP to the cGMP values is of importance rather than the latter values for themselves. For the benign tumor, this quotient differs only slightly from that of the adjacent normal, sound tissue. On the other hand, for the two malign tumors a drastic decrease of the quotient as compared to that of the normal tissue was found to occur.
Onkologie 1978 Dec
PMID:[Ratio of cyclo-3':5'-adenosinemonophosphate to cyclo-3':5'-guanosine-monophosphate in human tumor tissue]. 21 50

Cancer chemotherapy was purely palliative until the early sixties. Tumor cures have been since obtained, first in malignant trophoblastoma and Burkitt's lymphoma, and more recently in Hodgkin's disease, diffuse histiocytic lymphoma, acute lymphocytic leukemia in children, Wilms's tumor and osteosarcoma. Preliminary data are suggestive of tumor cures in testicular teratomas and, possibly, in small cell carcinoma of the lung. Five patients with trophoblastoma, Hodgkin's disease, melanoma, chronic myelocytic leukemia and anaplastic carcinoma of the lung are briefly presented, all without evidence of tumor relapse 3 years or more after chemotherapy. Theoretical bases for improvement of the curative effect of cancer chemotherapy are discussed, including the development of new agents, and new pharmacological problems concerning drug interactions, complexes of drugs with macromolecules or immunoglobulins and liposomes are considered.
Schweiz Med Wochenschr 1978 Dec 09
PMID:[Curability of malignant neoplasms: value and limitations of chemotherapy]. 21 68

Biopsy of melanoma is discussed in respect of the operator, the adequacy of biopsy, and the time delay till wide excision; statistics are taken from a series of 509 patients with this disease who had their definitive surgery and review at the Peter MacCallum Clinic between 1954 and 1973. Wide excision is described in respect of its origins and its proponents, and discussion draws on appropriate material from the series.
Aust N Z J Surg 1977 Dec
PMID:Aspects of surgical treatment for malignant melanoma: the place of biopsy and wide excision. 27 20

3,4-Dihydroxybenzylamine (DHBA), a dopamine analog, was much less toxic than dopamine when tested against the B16 melanoma in vivo and in vitro. Daily doses of 1,000 mg DHBA/kg were better tolerated than doses of 400 mg dopamine/kg. When tested against the B16 melanoma in (C57BL/6 x DBA/2)F1 mice, DHBA had a significantly improved therapeutic effect as shown by a life-span increased 70% as compared to 48% with dopamine. DHBA shared the catecholamine property of selectively inhibiting thymidine incorporation as compared to leucine or uridine incorporation. Because the inhibitory effects of DHBA on the B16 melanoma cells in vitro were similar to those of dopamine, much of the improved efficacy in vivo might be attributed to decreased toxicity.
J Natl Cancer Inst 1979 Dec
PMID:3,4-Dihydroxybenzylamine: a dopamine analog with enhanced antitumor activity against B16 melanoma. 29 14

A bioassay, based on tumorigenicity, has been developed to determine the mechanism whereby the blastocyst of the mouse controls malignant expression of embryonal carcinoma. The assay is based upon the incidence of tumors obtained when known numbers of cells of the 402AX strain of embryonal carcinoma are injected into strain 129 mice, compared to the incidence obtained when the same number of embryonal carcinoma cells are incorporated into Swiss-Webster blastocysts that are then injected in strain 129 animals. The results indicate that the blastocyst can regulate one embryonal carcinoma cell consistently; it may have a slight effect on three, but it cannot regulate four or five of them. The position of the embryonal carcinoma cell in the blastocyst is important. Regulation occurs if the embryonal carcinoma cell is placed in the blastocoele cavity, but enhancement of tumorigenicity is obtained if it is placed between the zona pellucida and the trophectoderm. By contrast, the blastocyst is unable to regulate a single B-16 melanoma cell placed in the blastocoele cavity, indicating a degree of specificity for the regulatory process.
Proc Natl Acad Sci U S A 1979 Dec
PMID:Tumorigenicity of embryonal carcinoma as an assay to study control of malignancy by the murine blastocyst. 29 49

A case of bilateral deposits from melanoma in the posterior frontal parasagittal region of the brain is recorded. A mechanism to explain the mode of spread is suggested. C.T. head scanning in patients with disseminated malignancy should be considered prior to invasive investigations or major surgical procedures.
Aust N Z J Surg 1979 Dec
PMID:Cerebral metastatic melanoma presenting as spastic paraparesis. 29 55

This study describes 18 months' experience with the CO2 laser in the treatment of malignant melanoma and other superficial malignancies. In 110 patients, a general assessment was made of the advantages commonly claimed for the laser. In addition, a comparison between laser and scalpel surgery was made by means of a small retrospective study. Results from 39 patients undergoing wide excision and graft for primary malignant melanoma in association with axillary lymph node dissection indicated that the laser offered no specific advantages over the scalpel for this particular type of operation. The laser was shown to have specific advantages in the treatment of extensive superficial malignancy, in locally recurrent tumours, and in malignancy of soft tissues. In these situations it did minimize blood loss and achieve satisfactory extirpation of the lesion.
Aust N Z J Surg 1978 Dec
PMID:Laser surgery for malignant melanoma and superficial malignancies. 29 14

Sixty-eight patients suffering from conjunctival melanoma were treated by beta-irradiation. The dose given ranged between 15,000 and 20,000 rd at the tumor surface. In 75% the therapy was successful. In 67,4% the melanoma could be cured by beta-irradiation alone with a follow-up period between three and ten years. The lethality rate from proven metastases was only 6.2%. The regression time after beta-therapy, as a rule, exceeded several months. Beta-rays can be used either primarily or after tumor excision. Care should be taken that the applicator covers all the tissue containing tumor cells.
Albrecht Von Graefes Arch Klin Exp Ophthalmol 1978 Dec 15
PMID:beta-Ray treatment of malignant epibulbar melanoma. 31 Nov 66

Clinical, histological, and electron-microscopic study of a leiomyoma of the ciliary body, which was removed by cyclectomy from the right eye of a 55-year-old female patient. This is the second case in the literature in which an excision has been performed and the diagnosis been confirmed by electron microscopy. The differential diagnosis between amelanotic malignant melanoma, schwannoma, and neurofibroma is discussed, and the electron-microscopic characteristics of a leiomyoma are demonstrated.
Albrecht Von Graefes Arch Klin Exp Ophthalmol 1978 Dec 15
PMID:Leiomyoma of the ciliary body. 31 Nov 71

Pregnancy-specific beta 1-glycoprotein, SP1, was measured in serum by competitive double antibody radioimmunoassay. Very low levels of SP1 or SP1-like activity were found in only 2 out of 85 sera from patients with cancer of the digestive tract, breast cancer, melanoma, and sarcoma, in 2 out of 11 sera from patients with infectious diseases, and in none out of 15 sera from non-pregnant healthy individuals. SP1 thus does not seem to be ectopically produced in vivo by the types of cancer studied, but is probably highly specific for the normal and malignant trophoblast.
Int J Cancer 1979 Dec 15
PMID:Is SP1 (pregnancy specific beta 1 glycoprotein) elevated in cancer patients? 31 95


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