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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Between 1975 and 1985 76 patients underwent surgery of pulmonary metastases in our hospital. Most often the primary tumor was located in carcinomas of the colon and rectum (19 patients), followed by carcinomas of the kidney (14 patients), the breast (13 patients) and the skin (malignant melanoma: 9 patients). Conditions for pulmonary metastasectomy are radical removal of the primary tumor, metastases located only in the lung, resectability of the metastases and low operative risk. Three years after pulmonary metastasectomy 35% of the patients were still alive, the 5 year survival rate was 18%. The median survival time was 22 months. The prognosis in patients with pulmonary metastases is largely dependant upon tumor type. Pulmonary metastases of breast carcinomas and carcinomas of colon and rectum can be treated best by surgical intervention. (5 year survival rate: 35% and 33%). Hypernephroma and malignant melanoma have a 5 year survival rate of 0% and 23%. Other prognostic factors are the number of pulmonary metastases and the disease-free interval between surgery of the primary tumor and pulmonary metastasectomy. Furthermore resection techniques are of prognostic importance. Lobectomy and segmental resection showed a better 5 year survival rate than pneumonectomy (21%, 24%, 0%). Median sternotomy is recommended as standard access for pulmonary metastasectomy. Surgery of pulmonary metastases is encouraging.
Thorac Cardiovasc Surg 1988 Apr
PMID:[Surgery of lung metastases]. 338 3

A case of pulmonary melanoma is presented. Because of the tumor's evolution and clinical features and, in particular, its pathoanatomic characteristics, we believe that it complied with sufficient criteria for classification as primary bronchopulmonary malignant melanoma. The literature is briefly reviewed.
Scand J Thorac Cardiovasc Surg 1987
PMID:Primary bronchopulmonary malignant melanoma. Case report. 361 45

A primary malignant melanoma of the oesophagus was surgically treated in a 71-year-old man. Maximally radical excision of the tumour was performed, with broad 'safety' margins and radical ablation of the para-oesophageal tissue at tumour level, without touching the tumour. When oesophagoscopy shows a tumour strongly suggestive of melanoma, confirmation should be made with fine-needle aspiration biopsy in preference to histologic biopsy, to avoid explosive spread of the tumour.
Scand J Thorac Cardiovasc Surg 1984
PMID:Primary malignant melanoma of the oesophagus. A case report. 652 76

The case histories of patients with primary cardiac neoplasms are presented. The mean age was 49.6 years and females predominated (17:8). Nineteen of the tumors were benign (76%), 18 myxomas and one mesenchymal hamartoma. There were six malignant neoplasms; two myxosarcomas, two rhabdomyosarcomas, one skeletal angiomatosis, and one malignant melanoma. The clinical presentation was congestive heart failure in 17 patients and peripheral embolization in five (one patient with both). There were four asymptomatic patients. Antemortem diagnosis was made in 20 patients and five were discovered at autopsy. After 1970, almost 95% of the patients were diagnosed preoperatively while only 14% of the patients had preoperative diagnosis before 1970. Cardiac catheterization and echocardiography were the most useful diagnostic procedures performed but a computed tomographic scan of the heart performed in a patient with right ventricular hamartoma was of great value in delineating the lesion. Twenty-one patients underwent a total of 26 operations but complete excision of the lesion was possible in only 16 patients. Three patients underwent extensive resection and reconstruction. Associated procedures consisted of coronary artery bypass grafts in two patients, mitral valve annuloplasty in one, and a right lung biopsy. Although there was no operative mortality following the original procedure, one patient died after a third operation for recurrence and another underwent unsuccessful emergency pericardiectomy. All patients with malignant lesions died from recurrence 6 to 13 months postoperatively while only three patients in the benign group died and these of unrelated causes. Surgical resection is the treatment of choice for all primary cardiac neoplasms since it is curative in the benign tumors and may prolong life for up to a year with malignant tumors.
J Thorac Cardiovasc Surg 1982 Mar
PMID:Primary cardiac tumors: experience with 25 cases. 706 46

Although melanoma that metastasizes to distant sites is generally associated with a median survival of only 6 to 8 months, certain metastatic sites including the lung may carry a better prognosis than others. Surgical therapy for pulmonary metastases remains controversial because of the variable survival rates reported for previous small series. To determine the prognosis and optimal management of patients with melanoma with pulmonary metastases, we reviewed our 22-year melanoma database of over 6100 patients. Of 984 patients with metastatic melanoma involving the lung or thorax, 106 underwent resection by posterior lateral thoracotomy or median sternotomy. There were no operative deaths, and the median follow-up period for surgical patients was 55 months. The remaining 878 patients were treated without operation with immunotherapy, chemotherapy, radiation therapy, or a combination. In both treatment groups the male/female ratio was approximately 2:1. The primary lesion's Clark level of invasion and Breslow thickness and the patient's age at diagnosis of metastatic disease were not significantly different between the two groups. The 1-year, 3-year, and 5-year survival rates for surgical patients were 77%, 37%, and 27%, respectively, compared with 32%, 7%, and 3% for nonsurgical patients; these differences were highly significant (p = 0.0001). The highest 5-year survival rate (39%) occurred in those patients with a single metastatic lesion. Sixty-three percent of the surgical patients received some form of immunotherapy, compared with 34% of the nonsurgical patients. Multivariate analysis showed that resection and immunotherapy with a melanoma cell vaccine were both independent predictors of survival (p < 0.0001). These results indicate that the prognosis associated with metastatic melanoma may be less dismal than previously thought when distant metastases involve thoracic sites. We believe that surgical resection is the treatment of choice for patients with melanoma with pulmonary metastases; when combined with immunotherapy, this regimen offers the best chance for long-term survival.
J Thorac Cardiovasc Surg 1995 Jul
PMID:Resection and adjuvant immunotherapy for melanoma metastatic to the lung and thorax. 760 35

We report herein the case of a 66-year-old man who underwent resection and reconstruction of the chest wall due to the presence of a malignant melanoma without a detectable primary lesion. The patient was discharged in good condition after receiving chemotherapy but eventually died of multiple bone metastases 2 years after surgery. Throughout the postoperative course, there were no specific symptoms or findings suggesting the presence of a primary lesion. It was considered likely that the primary tumor was resolved by spontaneous regression after chest wall metastasis had been established.
Jpn J Thorac Cardiovasc Surg 1998 May
PMID:Malignant melanoma of the chest wall with an unknown primary lesion. 965 18

We herein report a case of a pulmonary metastatic tumor with an endobronchial growth pattern. A 75-year-old female was operated on for pulmonary metastasis which originated from a malignant melanoma of the upper gum. Computed tomography (CT) of the chest demonstrated a solitary mass in right S6 region and a preoperative bronchoscopic examination revealed an endobronchial tumor in rtB6b. A retrospective analysis of the chest CT showed a thickened bronchial wall extending to the entrance of rtB6b. Therefore, not a wedge resection but a segmentectomy (rtS6) was performed. When the surgical margin is determined, we should therefore keep in mind the possibility of an endobronchial growth pattern if only a solitary mass is recognized on the CT, even though pulmonary metastatic tumors showing an endobronchial growth pattern is uncommon.
Ann Thorac Cardiovasc Surg 2000 Oct
PMID:Pulmonary metastasis with an endobronchial growth pattern: report of a case. 1117 40

We report a case of a 62-year-old woman with primary leiomyosarcoma of the chest wall which was successfully resected under the video-assisted thoracoscopic approach. The disease was found during the treatment for a malignant melanoma of the left heel. On the preoperative CT images, the lesion was suspected to be a metastasis of the malignant melanoma. The thoracoscopic surgery revealed that the tumor originated from the parietal pleura, and it was resected with a 5-mm margin of normal pleura. Histopathologically, the tumor was diagnosed as low-grade leiomyosarcoma. Since no residual tumor cells were proven in the resected margins histologically, further resection was not performed. At present, she is alive and well with no sign of recurrence of leiomyosarcoma two years and one month after operation. Thoracoscopic surgery is worth trying for accurate diagnosis of and effective treatment for a chest lesion without apparent invasion of the chest wall on the preoperative CT images.
Ann Thorac Cardiovasc Surg 2001 Dec
PMID:A case of primary leiomyosarcoma of the chest wall successfully resected under the video-assisted thoracoscopic approach. 1188 77

Melanoma is the most deadly of skin cancers, and metastatic disease most commonly first appears in the lungs. Because most patients with early metastatic pulmonary disease are asymptomatic, routine screening with chest radiographs is the most cost-effective method of discovery. The therapy for pulmonary metastatic melanoma has drastically changed over the years. Even today there is no curative immunotherapy or chemotherapy available. The long-term overall survival for these patients is still very poor, but early detection and surgery offers the only hope for control in a small number of patients.
Semin Thorac Cardiovasc Surg 2002 Jan
PMID:Pulmonary metastasectomy for metastatic malignant melanoma. 1197 16

A rare tumor with an unusual presentation can pose a diagnostic and management dilemma. In this paper, we will discuss the management of a 47-year-old lady with melanotic schwanoma of the esophagus who presented with superior vena caval obstruction. The initial histological diagnosis of esophageal metastatic malignant melanoma did not corroborate the clinical and operative findings. Further evaluation revealed positivity for HMB45, S-100 protein, and vimentin, and confirmed the diagnosis of melanotic schwannoma.
Thorac Cardiovasc Surg 2002 Apr
PMID:Esophageal melanotic schwannoma presenting with superior vena caval obstruction. 1198 13


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