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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 54-year-old man had a fleshy pink vascularized mass in the superonasal quadrant of the right iris. He had a history of an unchanging pulmonary nodule that was followed up for five years with routine chest roentgenograms. Fluorescein angiography demonstrated early filling of numerous fine blood vessels in the mass and diffuse late staining of the lesion. Results of a transcorneal radioactive phosphorus (32P) uptake test were positive. The clinical diagnosis was tapioca melanoma of the iris, with metastatic tumor as a second possibility. The tumor was excised by iridocyclectomy. Light microscopy revealed nests of tumor cells with oval hyperchromatic nuclei. Fontana stains for melanin were negative as were argentaffin and argyrophil strans. Electron microscopy demonstrated light and dark tumor cells containing numerous membrane-bound electron-dense neurosecretory granules. The diagnosis was iris metastasis from a probable bronchial carcinoid. The patient is alive and well years after excision of the iris mass.
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PMID:Iris metastasis from a bronchial carcinoid tumor. 20 56

An amelanotic fundus lesion in a 35-year-old man was associated with a dilated retinal vessel, thus suggesting the diagnosis of retinal angioma. Fluorescein angiography and B-scan ultrasonography were not diagnostic, but a radioactive phosphorus uptake test suggested the lesion was malignant. The enucleated globe showed a malignant choroidal melanoma drained by a large retinal vein.
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PMID:Choroidal melanoma clinically simulating a retinal angioma. 61 87

TWe have outlined a systematic approach to the management of choroidal lesions which might appear to be choroidal melanoma: 1. When a solid, elevated mass is suspected of being a malignancy, first complete a thorough examination of both eyes, including a detailed history. Arrange for a general medical evaluation to detect sources of metastatic lesions or early metastases from the eye. 2. Eliminate the possibility of flat choroidal lesions by slit-lamp and indirect ophthalmoscopic examination. These are considered benign and can be followed at routine intervals with simple sketches or color fundus photographs. Fluorescein angiography is not essential, but can confirm the benign appearance and help in following overlying secondary changes such as pigment epithelial defects. 3. Rule out serous or cystic lesions by the use of slit lamp and fundus contact lens, and indirect ophthalmoscope with transillumination. Fluorescein angiography again can help confirm the benign nature of these lesions, but the serial fundus examinations are definitive in 99 percent cases. 4. Document the appearance of the lesion with drawings, stereo-photographs, and stereo angiography. Follow the evolution of the lesion with these modalities for a sufficient time to be certain of the diagnosis. 5. Follow lesions in the peripapillary area with particular care.
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PMID:The management of choroidal tumors. 86 93

We compared the properties in human melanoma cell line A875 and rat pheochromocytoma cell line PC12 of nerve growth factor receptor (NGFr). We also analyzed NGFr and a truncated NGFR lacking the cytoplasmic domain, which were transiently expressed in COS cells. The full-length NGFR expressed in COS cells bound nerve growth factor (NGF) with positive cooperativity, but A875 NGFr and truncated NGFr in COS cells did not display positive cooperativity. The anti-human NGFr monoclonal antibody NGFR5 was characterized and found not to compete with NGF for binding to NGFr. Fabs were prepared from NGFR5 and 192, an anti-rat NGFR monoclonal antibody that was previously shown not to compete with NGF for binding. Fluorescein-labeled Fabs were used to measure the distribution and lateral diffusion of the NGFr. NGFr expressed on COS and A875 cells are diffusely distributed, but NGFr on the surface of PC12 cells appeared, for some cells, to be patched. In A875 cells, 51% of the NGFr was free to diffuse with diffusion coefficient (D) approximately 7 X 10(-10) cm2/s. In COS cells, 43% diffused with D approximately 5 X 10(-10) cm2/s. There was no significant difference in diffusibility between the full-length NGFr and the truncated NGFr. We compared NGFr diffusion on PC12 cells in suspension or adherent to collagen-coated coverslips. For suspension cells, we obtained 32% recovery with D approximately 2.5 X 10(-9) cm2/s. On adherent cells, we obtained 17% recovery with 6 X 10(-9) cm2/s. Binding of NGF enhanced lateral diffusion of NGFr in A875 cells and in PC12 cells in suspension but did not alter lateral diffusion of NGFr in COS cells or in adherent PC12 cells. NGF had no effect on the diffusing fraction or the distribution of NGFR for any cell line.
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PMID:Lateral diffusion of nerve growth factor receptor: modulation by ligand-binding and cell-associated factors. 196 90

We retrospectively studied the value of iris fluorescein angiography in predicitng benignity or malignancy in 10 cases of ciliary body melanoma with iris extension. No correlation between fluorescein-angiographic appearance and histopathologic features was observed. Fluorescein angiography adds little to the management of ciliary body melanomas with iris extension.
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PMID:Fluorescein angiography in ciliary body melanomas. 223 16

A 50-year-old man presented with a reddish, well-vascularized mass in the region of a nasal iridodialysis of his left eye, pushing the whole iris in this sector forwards; the mass had a pinkish, partly cystic appearance in the pupil. The tumour was transparent on diaphanoscopy. A-scan sonography revealed a solid tumour of the ciliary body with partial retinal detachment suggesting a malignant melanoma. Fluorescein biomicroscopy did not confirm this suspicion. The enucleated eye demonstrated a malignant teratoid medulloepithelioma of the whole nasal and lower ciliary body, infiltrating the deep iris stroma, the anterior choroid, the neighbouring vitreous body and spreading along the inner retinal surface back to the equator of the eye. The occurrence of medulloepithelioma in adult and senior persons is rather exceptional and this is the reason for this publication.
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PMID:Malignant teratoid medulloepithelioma in an adult. 403 61

Cell surface carbohydrates play an important role in several biological, immunological, and neoplastic phenomena including development, growth regulation, cellular locomotion, receptor activation, and tumour metastasis. Fluorescein labelled lectins which bind to specific carbohydrate residues in glycoproteins and glycolipids are being increasingly used as chemical probes to study cell components. Several different preparations of ocular tissues from human, rabbit, and rat were examined for the distribution of N-acetyl-D-galactosamine (D-gal NAc) by means of fluorescein-labelled lectin from soybean (glycine max). A very strong fluorescence was observed in the corneal epithelium; Descemet's membrane and corneal endothelium were also strongly fluorescent. The conjunctival epithelium similarly showed a strong reaction, as did the goblet cells. The iris epithelium and the dilator pupillae were only weakly fluorescent, but the ciliary body showed strong fluorescence, as did the blood vessels. As compared with lens fibres the lens epithelium was strongly fluorescent. The outer retina, that is, the photoreceptors, the pigment epithelium, and Bruch's membrane, showed a very strong reactivity. The optic nerve showed moderate fluorescence, but reaction with extraocular muscles was variable. The skin of the upper and lower eyelids, hair follicles, and blood vessels showed strong lectin binding. Sections of retinoblastoma and malignant melanoma showed no reaction. The physiological and pathological significance of these findings is discussed.
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PMID:Physiological and pathobiological significance of ocular glycoproteins. I. Studies using fluorescein labelled glycine max. 403 83

Concanavalin A (con A) is a plant-derived lectin that has the capability of agglutinating malignant cells in vitro. We studied the binding of fluorescein isothiocyanate-conjugated con A to formalin-fixed, paraffin-embedded malignant melanomas and nevocellular nevi. Both malignant melanoma cells and nevus cells emitted partial or circumferential, cytoplasmic rim, apple green fluorescence. There was no demonstrable difference between fluorescence distribution or intensity between the two groups. Control, unstained tissue specimens yielded a brilliant nuclear and nucleolar yellow-green autofluorescence, which is peculiar to melanoma cells and rare to absent in nevus cells. Fluorescein isothiocyanate-conjugated con A provided no clear differentiation between malignant melanomas and nevocellular nevi in fixed tissue. However, characteristic melanoma cell autofluorescence may prove to be of benefit for differentiating malignant melanocytic from benign nevocytic lesions.
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PMID:Fixed-tissue binding of fluorescein-conjugated concanavalin A to malignant melanomas versus nevi. 649 Sep 86

Using only a few tests, it was possible to differentially diagnose a benign choroidal nevus with overlying medullation. Having revealed a flat retina with no apparent mass in the area, the ultrasound B-scan initially ruled out a choroidal malignant melanoma, choroidal hemangioma, metastatic tumor and a rhegmatogenous retinal detachment. Binocular indirect ophthalmoscopy and application of the Goldmann 3-mirror gonioscopy lens revealed that the lesion was not a retinal detachment. Due to the location of the lesion, disciform macular degeneration was also ruled out. Fluorescein angiography was the final test which aided in the definitive differential diagnosis, since it was characteristic of a choroidal nevus. Even though not all possible choroidal nevi need such an extensive work-up, occasionally specialized test can aid in the differential diagnosis of benign from potentially malignant lesions.
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PMID:Choroidal pigmentation - a differential diagnosis. 726 44

The clinical and anatomopathological features of angioma of the iris are described and the relevant literature is briefly reviewed. A personal case in a 47-year-old woman is presented. Reference is made to the fact that, unlike many of the cases in the literature, histological confirmation of the diagnosis was obtained. Mention is also made of the importance of fluorescein angiography in the differential diagnosis of other forms, particularly melanoma. Fluorescein angiography, for the first time applied to angioma of the iris in the present case, enabled a satisfactory result (follow-up of 8 months) to be obtained by conservative iridectomy, in line with the recent approach to the management of this form.
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PMID:Angioma of the iris. 744 86


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