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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases of malignant melanoma resembling spindle and epithelioid cell nevus histologically are presented. Lesions having histologic features of spindle and epithelioid cell nevus (Spitz nevus or juvenile melanoma) at or after puberty should be regarded with caution, particularly when they are heavily melanized. Such lesions are in a histologic "gray zone" and may be malignant.
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PMID:Melanoma resembling spindle and epithelioid cell nevus. 53 85

The technique and results of 30 iridocyclectomies performed by the senior author are reviewed. Although the total number of cases is small for statistical purposes, its main value is that all the operations were performed by one surgeon, which means a uniform criteria for the indications, surgical technique, management of complications, immediate and postoperative decisions, follow-up control, and direct discussion of the histopathology with the pathologist. Three techniques were used: (1) routine excision only of uveal tissue in 15 cases, (2) cyclectomy, ie, plus excision of deep scleral wall in four cases, and (3) block excisions of cornea, sclera, affected iris, and ciliary body followed by a reconstructive penetrating graft in 11 cases. Twenty-one cases were melanocytoma; one, metastatic tumor; one, nevus; two, cysts; and three, foreign body granulomas. Prognostic features such as cell type, largest diameter above 10 mm, tumor thickness, tumor at edge, iris or ciliary body origin, location, and preoperative glaucoma are discussed, and some practical conclusions are advanced. The follow-up control for 21 melanoma cases in the series is five to ten years or more in 11 cases and up to four years in ten cases. The visual results are also analyzed.
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PMID:Iridocyclectomy technique and results. 53 91

A case of juvenile melanoma which appeared to be completely intradermal was studied by optical and electron microscopy. The histological dopa reaction was negative and melanin granules could not be detected with Fontana-Masson stain, but detailed electron microscopic examination revealed melanosomes very similar to those found in intradermal nevus cells. The tumor was therefore thought to be composed exclusively of melanogenic nevus cells, and participation of schwannian nevoblasts could be excluded. This view would support the concept of the unitary origin of such nevus cells.
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PMID:Juvenile melanoma--a case report and histogenetic investigation. 58 42

151 patients with benign giant pigmented nevi registered in the Danish Health system during the 60-year period 1915-75 were retrieved via the national register. A questionnaire was sent to all surviving patients asking for information about their health and especially whether they had had any treatment or had observed any changes in the nevus. All of the patients replied to the questionnaire. No patients had been cured from malignancy or were alive with known malignancy. Three patients had died from malignant melanoma during the period of observation. These case histories are reported. It is calculated that 4.6% of the patients with congenital giant nevi should be expected to develop malignant melanoma provided the incidence is the same in all age groups. Some uncertainty remains on account of the limited number of cases and an unsettled question about a higher incidence in childhood.
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PMID:The incidence of malignant transformation in giant pigmented nevi. 60 99

Distinctive melanocytic moles are described in 37 patients from six melanoma families. Among the family members examined by the authors, 15 of 17 patients with melanoma and 22 of 41 nonmelanoma relatives had the unique moles. The clinical and histological features of these moles have been designated the "B-K mole syndrome." The clinical features of the syndrome include the presence of less than 10 to greater than 100 moles prominent of the upper trunk and extremities, and variability of mole size (5 mm to 15 mm), outline, and color combination. Histologically, B-K moles show atypical melanocytic hyperplasia, lymphocytic infiltration, delicate fibroplasia, and new blood vessels that occur within a compound nevus or de novo. The transformation of two B-K moles into malignant melanomas was documented photographically.
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PMID:Origin of familial malignant melanomas from heritable melanocytic lesions. 'The B-K mole syndrome'. 64 94

A ciliary body tumor that was believed clinically to be a malignant melanoma developed in a 28-year-old woman and led to enucleation of her eye. The light microscopic appearance of the tumor was interpreted by light microscopy as a neurogenic neoplasm, possibly a choristomatous astrocytoma. Electron microscopic studies disclosed the smooth muscle origin of the tumor. Results of experimental embryologic studies performed on lower animals have proved that the neural crest contributes most of the connective tissues, "mesectoderm," of the globe and orbit in these species. The occurrence of hybrid neurogenic-myogenic tumors in the human eye supports the applicability of these embryologic discoveries to man. The association of a pigmented nevus with the present tumor is additional evidence of the neural crest origin of mesectodermal leiomyomas, since melanocytes are well-recognized descendants from the neural crest.
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PMID:Mesectodermal leiomyoma of the ciliary body associated with a nevus. 64 98

Melanocytomas are pigmented tumors of the uvea and optic nerve head composed of plump polyhedral melanocytes which have been regarded as nevus cells. There are few reports of malignant change in these usually benign lesions. This study documents 16 cases of malignant melanoma of the uvea, eight of which were characterized by the presence of plump polyhedral melanocytes in and around the tumor. The melanocytoma cells were aggregated throughout the tumors and/or at the margins of the lesions; these cells did not appear between the melanoma and the sclera, as has been reported with spindle-type nevus cells. Electron micrographs of these plump melanocytes had the characteristics of common uveal melanocytes, while the tumor cells had features of malignant melanoma cells. The clinician should recognize the potential of melanocytomas for undergoing malignant change and should follow patients who have this lesion with this in mind. Article is followed by comments of Dr. L. E. Zimmerman.
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PMID:Malignant change in melanocytomas of the uveal tract. 67 2

Since the entity of "juvenile melanoma" was first described, many pathologists have been reluctant to diagnose malignant melanoma in childhood by pathologic criteria alone. In this series of 125 cases, pathologic criteria are used to distinguish malignant melanoma of childhood from spindle and epithelioid nevus. Among the patients reviewed, 110 cases (86%) occurred between ages 13 and 20 years, and 15 cases (14%) in children under 12. There were 60 males (54%) and 50 females (46%) in the older age group, and six males (41%) and nine females (59%) in the childhood group. In the 13 to 20 age group, there were 24% head and neck primary melanomas, 38% truncal primaries, 30% limb primaries, and 7% indeterminate, as opposed to 35% head and neck, 23% truncal, and 41% limb in the group under 12. In the 13 to 20 year group, 66% were stage I, 11% stage II, 12% stage III, 2% stage IV and 7% indeterminate while in the 12 and under group, 76% were stage I, 12% stage III, and 12% stage IV. Mortality rates were 49% for the 13 to 20 year group and 60% for the 12 and under group.
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PMID:Malignant melanoma in children and young adults: effect of diagnostic criteria on staging and end results. 68 94

Malignant melanoma can be diagnosed at an early biological stage when relatively simple excisional surgery carries a remarkably good prognosis. For this to happen requires good public education, so that patients are aware of the potential danger of any change in a mole, and good professional education, so that physicians of first contact are alert to the possibility of melanoma in these patients.
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PMID:Modern concepts of melanoma and its management. 74 16

An unusual giant pigmented nevus, containing lymphocytic infiltrates and apparent muscle invasion, but without the presence of melanoma, is described in detail--including its related immunological parameters. The controversy concerning the malignant potential of giant pigmented nevi, and the paradoxes that are encountered clinically, are discussed.
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PMID:Defining the malignant potential of the giant pigmented nevus. 77 10


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