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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The specific cell-mediated immunity of the lymphocytes of eight patients with choriodal malignant melanoma (MM) to four extracts of choroidal MM-associated antigens was tested with the aid of the MIF technique. Seven of the patients with choroidal MM responded to at least one of the four extracts used, whereas patients with choroidal nevus or carcinoma as well as healthy controls did not respond to any of the MM choroidal extracts. There was no response to iris extracts obtained from the enucleated eyes with MM in any of the subjects tested.
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PMID:Inhibition of macrophage migration by choroidal malignant melanoma-associated antigens in patients with unveal melanoma. 35 88

The rates of adhesion of melanoma cells (carcinogenic) onto nonionic polymer surfaces were studied by using radioactively labeled cells and measuring the fraction of cells which adhered to the surface in a given time. Glow discharge (plasma) polymerization of 1,1,3,3-tetramethyldisiloxane and of nitrogen-acetylene-water (mole ratio 0.4:1.0:0.2) was used to modify the surface energy of the substrate. The cell adhesion rate was found to be given by Y = 1 - exp [-k0(gammas - gamma0)t], where Y is the fraction of cells adhered, -k0 is a characteristic rate constant, gammas is the total surface energy of the substrate, gamma0 is the threshold surface energy of cell adhesion, and t is time.
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PMID:The rate of adhesion of melanoma cells onto nonionic polymer surfaces. 35 60

By now it is well recognized that there is a benign melanocytic nevus, common in the young and common enough in adults, that has histological features that are confusable with those of malignant melanoma. The anomaly is usually referred to as benign juvenile melanoma, sometimes as Spitz's nevus, and, by some histopathologists, as spindle and epithelioid cell nevus. All the histological subtleties and variations of the condition are still not fully appreciated and some of them are still being misinterpreted as those of malignant melanoma. We herewith present a study designed to clarify the issue and offer firm criteria for histological differentiation of the nevus in point from malignant melanoma. We also suggest a new name for it and supporting arguments therefor.
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PMID:Nevus of large spindle and/or epithelioid cells (Spitz's nevus). 36 81

Human melanoma cells, freshly obtained from nine primary and metastatic melanoma cases, were tested for binding of monoclonal anti-melanoma antibodies produced in vitro by hybridoma clones. Monoclonal anti-melanoma antibodies bind to melanoma cells but do not react with nonmalignant cells obtained from the same patients or with cells obtained from giant hairy nevus. These results confirm the existence of tumor-specific antigens. Binding of monoclonal antibodies to melanoma cells of several origins, primary or metastatic, from different patients suggests the existence of tumor antigens shared by human melanoma cells. The binding pattern of different antibodies to various cells also predicts the existence of more than one tumor-specific antigenic determinant on melanoma cells.
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PMID:Reactivity of monoclonal anti-melanoma antibodies with melanoma cells freshly isolated from primary and metastatic melanoma. 37 94

Halo naevus cells on frozen sections react with sera from patients with benign halo naevus or with malignant melanoma. Halo naevus cells also react with our specifically absorbed heterologous antihuman malignant melanoma antiserum (RAMMA). Since the cytoplasm of all the naevus cells within the halo naevus react with sera from patients with malignant melanoma, this implies that the entire population of melanocytic cells in the mole has undergone mutation, because non-pathological skin melanocytes do not react.
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PMID:Melanocyte mutation in halo naevus and malignant melanoma? 37 50

A white woman with unilateral nevus of Ota presented with visual loss and an intraocular mass resembling a choroidal melanoma. Indirect ophthalmoscopy, fluorescein angiography, ultrasonography, and radioactive phosphorus uptake corroborated the clinical impression and surgery was advised. Following enucleation, the specimen was examined with light microscopy, which revealed a mixed cell type malignant melanoma of the choroid. Electron microscopy disclosed the presence of premelanosomes in the episclera, indicating that the episcleral pigmentation is a result of melanocytic evolution. This paper represents the tenth report in the literature of choroidal melanoma occurring in a patient with nevus of Ota, and the first electron-microscopic study of an eye with this association of lesions.
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PMID:Malignant melanoma of choroid in a case of nevus of Ota. 43 36

A sixty year old white woman with a history of Peutz-Jeghers syndrome with nail involvement, presented with a marked hyperpigmentation of the terminal phalanx and nail of the right index finger. Two preceding biopsy specimens from the fingertip were interpreted as junction nevus. After amputation of the fingertip and terminal phalanx, the final diagnosis was subungual malignant melanoma. Further amputation of the entire finger and portion of the corresponding metacarpal bone was done as a successful follow-up procedure.
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PMID:Subungual malignant melanoma. 45 29

5 1/2 years after excision of pigmented malignant melanoma which apparently arose in a nevus of the paralimbal bulbar conjunctiva, this 42-year-old male presented himself with a nonpigmented mass of the lid margin which also proved to be a malignant melanoma. "Acquired melanosis sine pigmento" was considered as a site of origin, but histopathologically there is more evidence that this melanoma arose in a non-pigmented compound nevus.
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PMID:[Multiple conjunctival malignant melanomas (author's transl)]. 45 34

A pigmented lesion developed in three patients in the center of the scar following excision and grafting to remove melanoma. Histologically, the lesions showed hyperplasia of melanocytes resembling junction nevus or lentigo maligna. Some site-specific factor seems to be responsible for this change.
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PMID:Pigmented lesion following complete removal of melanoma. 48 87

Six patients with prepubertal malignant melanoma are presented. Three were metastatic. One was congenital in a giant pigmented nevus. A second was found at 6 mo of age to have metastatic lesions. All were treated aggressively and had a favorable outcome. Aggressive treatment, once malignant melanoma is diagnosed, is recommended. Prognosis does not differ markedly from similar lesions in adults.
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PMID:Malignant melanoma in children. 49 Feb 95


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