Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A presentation is given of a malignant melanoma of the choroid of a 15-year-old girl. The tumor was erroneously considered as to be a subretinal hemorrhage produced by a choroidal rupture after an accident. A beginning melanosis bulbi resulted in the enucleation and the histological examination of the eye, which confirmed malignant melanoma of the choroid.
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PMID:[An error in the fluorescence angiographic diagnosis of a subretinal process (author's transl)]. 75 Jul 1

Mucosal melanoma of the head and neck is a rare condition. This study presents a review of 26 patients with such tumors, followed up at a minimum of 5 years. The 5-year survival rate in this group was 38%. Recurrences with a fatal outcome, however, have been encountered up to 12 years after initial diagnosis. Primary radical surgery offers the best chance for local control. Nasal-cavity lesions seem to be associated with a better prognosis than oral-cavity tumors. Analysis of pathologic features by microstage measurement showed that the majority of tumors were of considerable thickness. This factor may partially explain the poor prognosis associated with mucosal melanomas in comparison to their cutaneous counterparts. Local recurrences and distant metastases were the principal causes of treatment failure. A persistent treatment policy, however, may still substantially prolong survival in such cases. Regional lymph-node metastasis did not pose a significant problem in the management of these tumors. Recognition of the nature and significance of the appearance of oral melanosis is stressed.
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PMID:Mucosal melanomas of the head and neck. 75 92

A case of neurocutaneous melanosis in a 15 year old male is described. A primary malignant meningeal melanoma caused the death of the patient in six months. The skin lesions were benign. The literature is reviewed, and the nature of the disease and its relationship with other phakomatoses is discussed.
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PMID:Neurocutaneous melanosis. Report of a case and review of the literature. 83 91

A 47-yr-old woman, complaining of shortness of breath, had a chest X-ray showing a right parahilar mass and bronchoscopic examination disclosed a bluish flat lesion on the posterior wall of the trachea at the level of the fifth and sixth rings. Histological examination of the resected segment of trachea and an adjacent lymph-node revealed a primary tracheal melanoma with lymph-node metastasis. Review of five reported cases and of the literature on mucosal melanomas disclosed that the flat configuration of the tumour and the abundance of melanophages observed in the present case were unique. Possible relationships to mucosal melanosis and squamous metaplasia were briefly discussed.
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PMID:Primary "flat" melanoma of the trachea. 87 30

Malignant melanomas are known to be prone to undergo spontaneous regression (spontaneous resorption). The morphological picture of this process similar to that in spontaneous regressions of nevuses (halo-nevus), pigmentous spots (Dubreille melanosis) and superficially spreading melanoma is described. Six observations of spontaneously regressing melanomas are presented. Resorption of pigmented malignant tumors is similar to radiation resorption of malignant melanomas. It is noted that spontaneous resorption of malignant melanomas does not improve their prognosis.
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PMID:[Spontaneous regression of malignant melanoma]. 90 5

A case of unilateral nevus of Ota was associated with ipsilateral ocular melanocytosis and contralateral malignant melanoma of the CNS. The malignant neoplasm may have arisen from an area of bilateral leptomeningeal melanosis associated with unilateral nevus of Ota.
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PMID:Nevus of Ota with contralateral cerebral melanoma. 91 Dec 55

Regarding the rare phenomenon of diffuse melanosis of the skin secondary to widespread melanoma, the possibility of a circumscribed melanosis in melanoma patients is hypothetically discussed on the basis of a personal observation. Microscopically, such a circumscribed melanosis appears as clusters of melanin-laden macrophages.
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PMID:[Does a circumscribed melanosis secondary to malignant melanoma exist?]. 91 44

A patient with widely metastasized malignant melanoma assocaited with diffuse melanosis is presented. The widespread metastases in liver; skin and tonsilla are remarkable. The cutaneous melanosis in the form of the slate-blue colour caused by the increased dermal melanin deposits can arise in two different ways. One possibility is that melanin or precursors can be released from liver or other metastases and reach the dermis via the circulation. On the other hand a diffuse direct haematogenic single cell metastatic formation in the dermis with melanin formation and release can occur. In the case of the described patient the first etiopathology is dominating as it is shown by the light and electron microscopical results presented here.
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PMID:[Diffuse melanosis in malignant melanoma]. 91 15

Malignant melanoma of the penis and male uretha are unusually aggressive tumors which only rarely are cured by radical surgery. Melanosis of the penis may be confused with malignant melanoma, and we report a case of melanosis originally diagnosed and treated as melanoma with survival for twenty years. We contrast this with another case of malignant penile melanoma with a fatal outcome.
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PMID:Benign melanosis and malignant melanoma of penis and male urethra. 94 77

A retrospective study of 23 conjunctival melanomas using the Clark classification revealed that the three most common forms of melanoma described in the skin--lentigo maligna melanoma (Hutchinson's freckle with melanoma), superficial spreading melanoma, and nodular melanoma--can be recognized in the conjunctiva. As in the skin, lentigo maligna melanoma appears to be associated with a good prognosis compared to the prognosis associated with superficial spreading melanoma. These two forms of melanoma are both associated with an intraepithelial stage and had previously been grouped under one designate, cancerous melanosis. They can be distinguished histologically although definite clinical differentiation will be determined in the future. Some melanomas with an intraepithelial stage, however, cannot be definitely classified. Relating all conjunctival cancerous melanoses to Hutchinson's melanotic freckle is no longer justified.
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PMID:Malignant melanomas of the conjunctiva. 96 90


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