Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A previous finding of pronounced excretion of trichochromes in a patient with metastasizing melanoma and diffuse melanosis prompted this study on trichochromes in another patient with these two features. The patient now reported also excreted large amounts of trichochromes. Iit is suggested that diffuse melanosis in metastatic melanoma patients is due to deposition of trichochromes in the tissue.
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PMID:Diffuse melanosis and trichochromuria in malignant melanoma. 9 71

A case of primary malignant melanoma of the esophagus in a 74-year-old male is described. There was a diffuse pigmentation of the lower third of the esophagus macroscopically. Sections from this area revealed melanocytes in the basal layer of the epithelium. This melanosis was not caused by malignant melanoma cells, but obviously by preexisting ectopic and pigmented melanocytes a condition for which the term "esophageal melanocytosis" is proposed. It is suggested that esophageal melanocytosis as well as the presence of junctional changes may determine the primary nature of malignant melanoma of the esophagus. Furthermore, in order to outline the histologic criteria and the pathological features of primary esophageal melanomas, 64 cases have been reviewed.
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PMID:Primary malignant melanoma of the esophagus. 16

A unique case of melanosis of the choroid plexus in a 74-year-old man who died of hypertensive cardiovascular disease is described. The cerebral lesion did not cause symptoms. The proposed pathogenesis is the conversion of choroidal epithelial lipofuscin into melanin. Our findings also may explain the origin of a previously reported primary malignant melanoma of the choroid plexus and of black cortical adenomas of the adrenal gland.
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PMID:Melanosis of the choroid plexua. 18 Apr 55

In accordance with microscopic and clinical criteria established for superficial melanomas of the skin (superficial spreading melanoma, lentigo maligna melanoma, acral-lentiginous melanoma), three oral lesions have been evaluated. The literature on oral melanomas has also been reviewed, with special attention given to those cases that had pre-existing melanosis. One patient with a diagnosis of superficial spreading melanoma eventually died of his untreated lesion 11 years after its first appearance. Two patients had lesions diagnosed as acral-lentiginous melanoma (a group which also includes volar and subungual melanomas) that exhibited aggressive, recurrent behavior. These lesions had microsocpic features similar to lentigo maligna melanoma but did not behave in a manner consistent with that diagnosis. Electron microscopic study of one acral-lentiginous melanoma demonstrated malenosomes and premelanosomes that were like those seen in normal melanocytes and nevus cells. The superficial or radial growth phase of many oral melanomas has apparently gone unrecognized. Melanosis has been reported to be a common feature of invasive oral melanomas but has not generally been related to the natural history of these lesions. Oral lesions with a prolonged intra-epithelial or radial growth phase would be expected to have a better prognosis than nodular melanomas, but meaningful survival data are not available because of the infrequency with which oral melanomas have been subclassified.
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PMID:Superficial melanomas of oral mucous membranes. 27 92

Thirty-five vulvectomy specimens were obtained from post-mortem material and studied to assess the distribution of melanin pigment. The information obtained was compared with the melanin distribution in melanoma-in-situ and melanosis vulvae. A lesion had to be larger than 3mm before it was recognised clinically. Melanosis vulvae is but an exaggeration of the normal distribution of melanin pigment. Melanoma-in-situ, however, cannot be reliably distinguished from the benign causes of pigmentation on clinical grounds. The correct diagnosis can only be made histologically. Other causes of vulval pigmentation are also discussed.
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PMID:An assessment of vulval pigmentation. 28 51

According to Clark there are three different types of melanoma: malignant melanoma which develops from the floor of a precancerous melanosis, the extensive superficial melanoma and nodular malignant melanoma. Therapeutically, surgery occupies the first place. Chemotherapeutically the combination of 3 or 4 different substances has given favorable results. Immunotherapeutically, immunization with BCG and mycobacteria, especially Cornyebacterium parvum, is considered the most reliable and least dangerous procedure. Altogether, a better prognosis for malignant melanoma can be expected in the future if diagnosis is made early and if treated with an optimum combination therapy.
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PMID:[Treatment of malignant melanoma (author's transl)]. 30 28

5 1/2 years after excision of pigmented malignant melanoma which apparently arose in a nevus of the paralimbal bulbar conjunctiva, this 42-year-old male presented himself with a nonpigmented mass of the lid margin which also proved to be a malignant melanoma. "Acquired melanosis sine pigmento" was considered as a site of origin, but histopathologically there is more evidence that this melanoma arose in a non-pigmented compound nevus.
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PMID:[Multiple conjunctival malignant melanomas (author's transl)]. 45 34

Report of a case with melanosis bulbi observed in a relatively young patient of 33 years, in which a malignant melanoma of the choroid developed. As reported in earlier examinations the incidence of malignant melanoma in cases of melanosis bulbi is much higher than in normal eyes. The authors recommend strongly routine biomicroscopic examinations in cases of melanosis bulbi every 1--2 years to recognize the development of a melanoma in an early stage.
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PMID:[Malignant melanoma of the choroid in melanosis bulbi (author's transl)]. 48 Aug 11

A melanoma of the uterine cervix, 4 mm in diameter, considered primary, in a 44-year-old pluripara is described. She was subjected to hysterectomy coupled with adnexectomy and also to BCG immunotherapy. A year following the beginning of the therapy she is without any symptom of the disease. The rarity of the tumour in this localization is pointed out, and a short review is given of the cases reported in the literature, including those of benign melanosis and "blue nevus". The histogenesis and cytologic diagnosis are discussed, as well as therapeutic possibilities. Emphasis is laid on the varying biological behaviour of the tumour which prevents the assessment of the therapy with regard to the possibility of a very late development of metastases.
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PMID:[Primary malignant melanoma of the uterine cervix]. 55 19

A case of primary acquired melanosis of the conjunctiva is reported. During the 18 years of observation the patient developed a malignant melanoma in the iris, and seven years later a malignant melanoma appeared in the lower lid. The iris melanoma may be an extension from the precancerous melanosis, but the most likely explanation is that the condition represents two independent diseases.
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PMID:Malignant melanoma of the conjunctiva and the iris in a case of primary acquired melanosis of the conjunctiva. 69 69


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