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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two cases of malignant melanoma on the toe of middle-aged women were examined chiefly by the fluorescence method of Falck and Hillarp. In one of the patients, histopathology of the pigmented tumor on the left middle toe was a Pagetoid (superficial spreading) melanoma in situ, and the subungual granulomatous lesion on the right great toe in the other patient was a lentigo maligna melanoma. On fluorescence microscopy, characteristic findings of the pigment cells lying in the epidermis of both types may be summarized as follows: In the Pagetoid melanoma, the melanoma cells are ovoid, lack dendritic processes, and emit specific yellow fluorescence. In the lentigo maligna melanoma, the pigment cells clearly show dendritic processes, and emit specific green fluorescence.
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PMID:Pagetoid malignant melanoma and lentigo maligna melanoma of toe. A study with the fluorescence method (Falck and Hillarp). 71 55

We have attempted to describe virtually all forms of malignant melanoma which affect man except those arising in the eye. The vast majority of malignant melanomas clearly fall into one of three kinds: (1) malignant melanoma of the superficial-spreading type, (2) malignant melanoma of the lentigo-maligna type, and (3) malignant melanoma of the nodular type. The developmental biology of a primary neoplasm is illustrated by discussing and illustrating the evolution of these three dominant forms of melanoma. Primary malignant melanoma of the superficial-spreading type and of the lentigo-maligna type develop through a characteristic biphasic growth pattern: an initial radial-growth phase, followed by a vertical-growth phase. The radial-growth phase of these melanomas is only rarely associated with the development of metastases, while the vertical-growth phase is commonly associated with subsequent metastatic disease. The phenomenon of the vertical-growth phase is apparently, therefore, a qualitative step in the development of a primary malignant melanoma. Malignant melanoma of the nodular type is an example of a primary tumor without a precursor developmental stage such as a radial-growth phase.
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PMID:The developmental biology of primary human malignant melanomas. 79 May 75

By means of histochemical methods (gel-film incubation-media) superficial spreading melanoma, nodular melanoma and lentigo maligna melanoma are investigated. The result of this examination is that with regard to their enzyme spectra, the nodular melanoma and the nodular part of the superficial spreading melanoma are very similar. Glucose-6-phosphate dehydrogenase shows the strongest enzyme reaction, followed by succinate dehydrogenase and lactate dehydrogenase. The beta-hydroxybutyrate dehydrogenase reaction is always weak. The reaction of acid phosphatase is between negative and weakly positive. Significant differences, however, are observed in lentigo maligna and in lentigo maligna melanoma. In both, the strongest formazan deposits are seen with succinate dehydrogenase, sometimes also with lactate dehydrogenase. The glucose-6-phosphate dehydrogenase reaction, however, is sometimes considerably weaker. In the case of lentigo maligna melanoma, the activity of beta-hydroxybutyrate dehydrogenase often is increased, and acid phosphatase also shows higher reactions than in the other melanomas. These differences in the enzyme pattern correspond to the different biological behavior of the tumours. The enzymatical and biological characteristics of lentigo maligna melanoma possibly derive more from the characteristics of the tumour itself which are not dependent on the area.
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PMID:Histochemical findings in different types of malignant melanoma: biological and clinical significance. 81 58

Two cases of desmoplastic malignant melanoma are described, bringing the total reported to nine. The first developed in a lentigo maligna melanoma and contains the seed of its local recurrence in the primary lesion. The second developed in a clinically apparent congenital nevus and unites the histologic features of the desmoplastic variant with the epithelioid and spindle cell histology of its primary, side by side in a local recurrence. Both primaries were clinically recognized pigmented lesions while the desmoplastic recurrences were amelanotic. Other clinico-pathologic characteristics of DMM as previously described, are confirmed. Light microscopic evidence is presented supporting the view that the desmoplastic reaction is a rare manifestation elicited by a highly invasive spindle cell component of malignant melanoma.
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PMID:Desmoplastic malignant melanoma: a report on two additional cases. 83 43

Microscopically controlled excision of melanoma by the chemosurgical method ensures complete eradication of any unsuspected outgrowths from the clinically observed tumor mass. The method differs from the chemosurgical techniques used for excision of cutaneous carcinomas in the following two respects: the tissues always are chemically fixed in situ before any incisions are made in order to minimize the chance of dissemination, and an extra margin of tissues is removed after reaching a microscopically melanoma-free plane in order to encompass possible outlying melanomatous satellites in the peritumoral lymphatics. In a series of 103 consecutive cases of melanomas of the nodular, superficial spreading, and lentigo maligna types, there were 86 determinate cases with a five-year cure rate of 50%. This is a high rate for a series in which 69% were nodular melanomas and 64% invaded to subcutaneous tissues (Clark's level 5).
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PMID:Chemosurgery for melanoma. 84 93

Hutchinson's melanotic freckle (lentigo maligna) is a well-known pigmented lesion, usually seen on the face of white patients. It may be associated with invasive malignant melanoma. This paper reports the incidence of this lesion in association with invasive malignant melanomas of the feet and hands of Black Africans. In Blacks, as in Whites, malignant melanoma with adjacent Hutchinson's melanotic freckle carries a considerably better prognosis than other histogenetic patterns of malignant melanoma.
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PMID:Malignant melanoma with adjacent Hutchinson's melanotic freckle in Black Africans. 87 85

The prognosis for malignant melanoma is dependent on the stage of the disease, sex, size respectively depth of penetration, structure (lentigo maligna melanoma, superficial spreading melanoma, nodular melanoma), location and age of the patient when the disease begins. The method of conventional treatment (X-ray then excision, excision then X-ray, X-ray alone, excision alone) is not important. The decisive factor is early diagnosis (histology) and early treatment (total excision of the tumor). The value of additional immunotherapy and chemotherapy in cases diagnosed early cannot yet be judged. Melanoma is rarer among colored races than among whites, and the frequency of the disease among Caucasians increases as one approaches the equator. Morbidity and mortality are rising throughout the world. The influence of factors such as trauma and sunlight is disputed.
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PMID:[Clinic, statistic and risik factors of the malignant melanoma (author's transl)]. 89 19

Sixteen patients were treated for melanotic freckle of Hutchinson (lentigo maligna) with the Miescher technique of x-ray therapy. Eleven patients had no local cutaneous recurrences of persistence following x-ray therapy. Five patients had local recurrence or persistence of their lesions. Three patients developed metastatic malignant melanoma. The first of these three patients had lentigo maligna melanoma, and the second patient had a melanotic freckle with atypical cells extending down the adnexae, including the sweat apparatus to the level of the coiled portion of one sweat gland. The third patient was considered to be in a precancerous phase at the time of irradiation. Nevertheless, metastases occurred. European colleagues indicate that they have not experienced such problems in using the Miescher technique. The procedure has been abandoned in our department, pending further clarification of the discrepancy between our results and those reported by our European colleagues.
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PMID:Treatment of melanotic freckle with x-rays. 94 13

Pathologic study demonstrated lentigo maligna melanoma in three of four cases of desmoplastic melanoma and demonstrated spindle cell masses with features of atypical fibroxanthoma in all four of the cases. Pigment enzymes of melanosomes were not found in the mesenchymal portion of the tumor. The cellular atypia and the histochemical and ultrastructural findings favor the fibroblastic nature of this melanoma-related dermal mass.
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PMID:On the nature of desmoplastic melanoma. 95 65

We described the three histogenetic forms of cutaneous melanoma--lentigo maligna melanoma, superficial spreading melanoma, and nodular melanoma. The first two forms have a flat spreading component or radial growth phase in the epithelium as well as in the invasive or vertical growth phase. Formerly these two lesions may have been confused with one another. Nodular melanoma has only the vertical growth phase. Examples of lentigo maligna melanoma and superficial spreading melanoma were found in eyelid lesions involving both the skin and conjunctiva. The distinctive histopathology of the cutaneous lesion was retained in the conjunctiva.
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PMID:Melanocytic lesions of the eyelid skin. 96 89


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