Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seventeen patients with ocular or oculodermal melanocytosis were identified among 1,250 Caucasian patients with uveal malignant melanoma. The uveal melanomas in these seventeen patients were similar in size, cell type, and tendency to metastasize to those occurring in reported populations without ocular or oculodermal melanocytosis. Clinical and histopathologic study of these 17 cases indicated that all of the affected eyes had episcleral and choroidal melanocytosis and that other ocular and periocular tissues (sclera, iris, conjunctiva, angle structures, and optic disc) were involved less commonly. The uveal malignant melanoma that was present in each of these cases involved the eye with melanocytosis. Furthermore, the melanoma arose from the zone of uveal melanocytosis in every eye with sectoral involvement. Statistical analysis of these data supports the contention that uveal malignant melanoma has a higher incidence in white persons with ocular or oculodermal melanocytosis than in those without these conditions.
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PMID:Uveal malignant melanoma associated with ocular and oculodermal melanocytosis. 713 41

The ophthalmology radioactive phosphorus uptake test has been utilized in the differential diagnosis of intra ocular lesions in 21 patients. In the majority of the cases the diagnosis was histologically confirmed. When the lesion is located in the anterior part of the globe, it is not necessary to make an incision of the conjunctiva to perform the test. If the lesion is located in the posterior segment, the test is performed by the transscleral route, with surgical incision of the conjunctiva and with indirect ophthalmoscopy control when possible. In 3 patients with choroidal hemangioma were results false-positives, observed with inferior P32 uptake to that in patients with choroidal melanomas. One false-negative result was obtained in a patient with a clinical diagnosis of uveal malignant melanoma, histologically confirmed after enucleation of the globe. In all others patients with uveal malignant melanoma results were highly positive.
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PMID:[Radioactive phosphorus uptake test in ophthalmology]. 715 62

Two cases of Reese's conjunctival melanosis are reported. Inflammatory signs revealed the presence of the lesion in a 58-year-old woman, examination demonstrating diffuse brown conjunctival, tarsal, and bulbar pigmentation in the right eye, raised above the surface at the sclerocorneal junction. Histology after exenteration demonstrated coexisting diffuse atypical melanocytic hyperplasia (precancerous melanosis), an intraepithelial melanoma (cancerous melanosis), and an invasive melanoma which was the object of an ultrastructural study. The second case, a 57-year-old woman, had a 20-year history of stable, diffuse black pigmentation of the bulbar conjunctiva of the right eye. Four months after biopsy, a pedunculated tumor of the internal canthus developed, corresponding to a poorly differentiated epithelioid cell malignant melanoma. These two cases are compared with similar observations reported in the literature.
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PMID:[Reese's conjunctival melanosis. Two anatomicoclinical observations with ultrastructural study in one case]. 716 9

A woman with bilateral ocular melanocytosis developed a malignant melanoma of the choroid in one eye. The ocular melanotic hyperpigmentation, present since childhood, clinically involved the conjunctiva and episcleral and uveal tract of both eyes. To our knowledge this is only the second reported case of a uveal malignant melanoma in a patient with bilateral ocular melanocytosis. There is evidence that patients with ocular of oculodermal melanocytosis have an increased incidence of malignant melanoma of the uvea. It is possible that patients with bilateral ocular melanocytosis have a greater chance of developing of uveal malignant melanoma than do those with unilateral involvement.
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PMID:Bilateral ocular melanocytosis with malignant melanoma of the choroid. 731 31

Two patients who had refused exenteration for widespread conjunctival melanoma were treated by a combination of cryotherapy and surgical excisions. Cryotherapy was delivered only to the extensive areas of flat intraepithelial melanocytic proliferation (precancerous melanosis), while the surgical excisions were performed on the focal nodules, representing localized invasive melanoma. In our two patients, the invasive nodules measured, respectively, 1.2 and 1.5 mm in greatest thickness, placing them in a low to borderline risk group for metastasis. Repeated cryoapplicatons were required to control the widespread flat intraepithelial disease. The conjunctiva tolerated these procedures well because the substantia propria is not sacrificed as it must be in surgical conjunctivectomy, allowing comparatively normal reepithelialization to occur from adjacent zones, after the treated epithelium containing the melanocytes sloughs. No evidence of invasive melanoma (cancerous melanosis) has developed in any of the cryotreated areas of intraepithelial disease (precancerous melanosis); sequential biopsies have established that the atypical melanocytes have disappeared from the epithelium.
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PMID:Combined surgery and cryotherapy for diffuse malignant melanoma of the conjunctiva. 741 74

Acquired melanosis is the clinical term used to describe a slowly enlarging, diffusely pigmented lesion of the conjunctiva which may also involve the lids, caruncle or cornea. The controversial histologic classifications are reviewed and suggestions made regarding useful and accurate terminology. In acquired melanosis, development of malignant melanoma may occur. Previous work indicates that the prognosis of the resulting melanoma may be assessed by histopathologic staging as is done in cutaneous melanoma. The suggested management of acquired melanosis is close observation with excisional biopsies of areas clinically suggestive of invasive melanomas. Examination of the entire biopsy by serial or staged sections is essential for accurate histopathologic diagnosis. Invasive melanomas have been conventionally treated by local excision or exenteration. Radiation therapy may be a beneficial adjunct.
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PMID:Idiopathic acquired melanosis. 744 16

The role of orbital exenteration in the management of malignant melanoma of the conjunctiva has been underexplored. The outcome in 95 patients with this condition, who underwent exenteration as a primary treatment (n = 36) or after failure of other treatment (n = 59) for early to advanced stages of the disease, was evaluated. The majority of treated cases had multicentric melanomas sited at prognostically unfavourable locations. In the group of tumours with a maximum thickness of 1.0 mm no melanoma related mortality was noted. Melanomas thicker than 1.0 mm were associated with a mortality varying between 33% and 50%, independent of whether exenteration was performed as primary or secondary treatment. An especially poor outcome was noted for the group of caruncular melanomas despite exenteration. These findings indicate that total eradication of tumour should be performed at an early stage. For this purpose, a combination of debulking surgery and adjunctive cryotherapy or beta radiotherapy is more appropriate than orbital exenteration which causes disfigurement and blindness. Exenteration of the orbit should be reserved as a palliative procedure for advanced stages of neoplastic disease.
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PMID:Orbital exenteration in 95 cases of primary conjunctival malignant melanoma. 752 45

Most melanomas in the orbital region are primary tumours. The uveal tract is the commonest site though the skin of the eyelids, the conjunctiva and, very occasionally, the orbit itself may be involved. Direct spread may cause the tumour to present in an adjacent structure so that a uveal tract melanoma with an extrascleral nodule may appear to arise in the conjunctiva or in the orbit whilst a conjunctival melanoma may first be apparent in the adjacent eyelid skin. Metastatic deposits from cutaneous melanoma may occasionally present in the eye or ocular adnexa.
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PMID:Management of ocular melanoma. 755 89

Minocycline can cause hyperpigmentation of the conjunctiva, oral mucosa, and skin. Pigmentation of the oral mucosa may also be associated with a variety of endogenous or exogenous factors. Lingual pigmentation may be seen in Addison's disease, amalgam tatoo, malignant melanoma, Peutz-Jegher's syndrome, and other diseases. Two women who had isolated pigmentation of the tongue while taking minocycline are described; no other drug-induced pigmentation of their oral mucosa or skin occurred. Minocycline-induced pigmentation should be added to the differential diagnosis of isolated lingual hyperpigmentation.
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PMID:Lingual hyperpigmentation associated with minocycline therapy. 761 81

The liquid nitrogen cryotherapy was used to treat conjunctival malignant melanoma. Light and transmission electron microscopic examinations were carried out before, during and after the treatment. It was discovered that the tumor cells died within a few minutes after the cryoapplication. Under transmission electron microscope, marked necrosis of tumor cells was seen 10-14 days after the treatment and a large amount of collagenous fibers and fibroblast hyperplasia were seen in the tumor in 3-4 weeks following the application, while the tumor cells were seldom found. Under light microscope, as significant necrosis of the malignant melanoma occurred, the surface conjunctival epithelium gradually grew and covered the defect of the conjunctiva, showing that the malignant melanoma cells are much more sensitive to the cryoapplication than the normal conjunctival epithelial cells.
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PMID:[Pathological and ultrastructural changes in conjunctival malignant melanoma treated by cryotherapy]. 784 24


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