Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rapidly proliferating tissue incorporates more phosphorus than normal. Thus, following administration of radioactive phosphorus (32P), tumors emit increased amounts of radiation which can be detected. With the proper test technique, a correct diagnosis rate of 96-100% is quoted in the literature. By comparison, between 4 and 20% of all eyes enucleated for suspected malignant melanoma without prior 32P testing contained no neoplasm histologically. The radiation exposure is minimal due to the short half-life of 32P and the low penetration of beta-particles. However, the test usually involves a small operation (conjunctiva and Tenon incision). Testing with gamma rays, however, is not yet wholly satisfactory due to the lack of a suitable gamma-ray detector.
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PMID:[The 32P test in ophthalmology]. 39 93

5 1/2 years after excision of pigmented malignant melanoma which apparently arose in a nevus of the paralimbal bulbar conjunctiva, this 42-year-old male presented himself with a nonpigmented mass of the lid margin which also proved to be a malignant melanoma. "Acquired melanosis sine pigmento" was considered as a site of origin, but histopathologically there is more evidence that this melanoma arose in a non-pigmented compound nevus.
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PMID:[Multiple conjunctival malignant melanomas (author's transl)]. 45 34

We encountered inverted papilloma of the conjunctiva in three cases. To the best of our knowledge, this tumor, which typically involves the nose, paranasal sinuses, and lacrimal sac, has not been described previously in the conjunctiva. Two of the tumors occurred as purely inverted lesions of the inner canthal region )caruncle and plica) and the third as a mixed inverted-exophytic papilloma over the tarsus. Melanotic pigmentation in one of the lesions was clinically confused with malignant melanoma. Because of the high incidence of recurrence of these tumors in the sinuses and lacrimal sac, and their unknown biologic behavior in the conjunctiva, inverted papillomas should be removed completely and the patients carefully observed.
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PMID:Inverted papilloma of the conjunctiva. 51 11

A report rarely a case of superficial spreading melanoma of the conjunctiva bulbi in a 40-year-old woman. As this kind of tumor is very found at this site, the unusual localisation rendered the differential diagnosis more difficult and delayed the radical operative therapy. After orbitectomy the patient has been free of local metastatic deposits for two years. She is fully rehabilitated by a good epithetis. The course of diagnosis in our case illustrates the necessity of uniform application of the nomenclature of cutaneous forms of melanomas and naevi in ophthalmology.
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PMID:[Epibulbar superficial spreading melanoma (author's transl)]. 69 43

A case of primary acquired melanosis of the conjunctiva is reported. During the 18 years of observation the patient developed a malignant melanoma in the iris, and seven years later a malignant melanoma appeared in the lower lid. The iris melanoma may be an extension from the precancerous melanosis, but the most likely explanation is that the condition represents two independent diseases.
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PMID:Malignant melanoma of the conjunctiva and the iris in a case of primary acquired melanosis of the conjunctiva. 69 69

A description is given of a cutaneous malignant melanoma in the region of the lid angle with involvement of the upper and lower lid and the tarsal and bulbal conjunctiva.
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PMID:[Problems of the cutaneous malignant melanoma near the eye (author's transl)]. 73 78

During the period 1954 to 1974 inclusive, fourteen patients with melanoma of the conjunctiva were observed in the Department of Ophthalmology, University of Amsterdam. Frequency, etiology and treatment are discussed. No statistically proven conclusions may be drawn from this investigation; not at any rate, in regard to the treatment due to lack of homogeneity of the approaches used in recent years.
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PMID:Conjunctival melanoma, a retrospective study. 86 12

From pertinent cases a contribution to the pathology of melanoma is published here. The histological structure of melanoma in the various eye tissues is dependent on the properties of the tissue in which the melanoma grows. By means of an example we have tried to throw light on the question of the differential diagnosis between a primary tumor and a metastatic deposit, although a single case cannot be used as proof. An intraocular degenerate melanoma and a melanomametastasis in the conjunctiva after a skin tumor are also demonstrated.
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PMID:[On the pathology of ocular malignant melanoma (author's transl)]. 86 91

Invasive malignant melanoma of the conjunctiva is a rare neoplasm fatal in 40% of cases. Accepted techniques of surgical management include wide local excision, conjunctivectomy, and exenteration. Recently lymphatic dissections have been proposed, but not described, for invasive conjunctival melanoma. We present five cases of invasive conjunctival melanoma, including two with intraglandular parotid metastases. The surgical management of these patients is presented, and a proposal is made for radical bloc dissection of the orbital contents and regional lymphatics. The histology of conjunctival melanoma is discussed, and a classification proposed to assist the head and neck surgical team in the management of this disease.
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PMID:Malignant melanoma of conjunctiva metastatic to parotid gland. Reports of cases and discussion of surgical management. 92 64

We described the three histogenetic forms of cutaneous melanoma--lentigo maligna melanoma, superficial spreading melanoma, and nodular melanoma. The first two forms have a flat spreading component or radial growth phase in the epithelium as well as in the invasive or vertical growth phase. Formerly these two lesions may have been confused with one another. Nodular melanoma has only the vertical growth phase. Examples of lentigo maligna melanoma and superficial spreading melanoma were found in eyelid lesions involving both the skin and conjunctiva. The distinctive histopathology of the cutaneous lesion was retained in the conjunctiva.
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PMID:Melanocytic lesions of the eyelid skin. 96 89


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