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Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is hoped that this review has given some information to direct the clinician in his approach to his patients. Certainly, we would desire that the incidence of malignant melanoma as well as other skin cancers would start to decrease.
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PMID:Sunscreen: one weapon against melanoma. 193 52

Although screening for melanoma and skin cancer is theoretically appealing, too few data exist to evaluate its effectiveness. The rising incidence and mortality rates of melanoma and the continued incurability of metastatic disease underscore the desperate need for effective screening. The extraordinary incidence of NMSC is a public health problem, but the value of screening for NMSC has not been established. The AAD screening program offers an opportunity to obtain critical data. Further research must make our screenings more effective and efficient. We need rigorous design and evaluation of all screening efforts. In the absence of a randomized controlled trial, other design measures, with careful tracking of incidence and mortality, are critical to assessing whether screening for melanoma and skin cancer can reduce morbidity and save lives.
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PMID:Can screening for melanoma and skin cancer save lives? 193 53

College and high-school students were administered a questionnaire to assess their knowledge about skin cancer, and afterward an educational program was designed to correct the identified deficiencies. Results showed that the students were relatively uniformed about how to recognize and prevent skin cancer--high-school students more so than college students--but that their knowledge of the disease (e.g., risk factors, preventive measures, and identification of "warning signs" for early detection) increased significantly after training. Some forgetting was noted at a 2-week follow-up but knowledge levels were still significantly higher than baseline. If these findings are representative of the general population, more preventive education will be needed in this area. This is especially true because the potentially deadly melanoma appears to be increasing at an alarming rate.
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PMID:Brief report: an empirically derived educational program for detecting and preventing skin cancer. 194 19

Incidence of various cancers was evaluated in a cohort of 5359 multiple sclerosis (MS) patients, identified through hospital discharge records between 1977 and 1987 and followed for an average of 5.2 years. Computerized linkage with the Danish Cancer Registry uncovered 210 cancer cases which was significantly more than expected based on national rates (relative risk (RR) = 1.29). Over half of the excess, however, was observed for non-melanoma skin cancer and tumors of the urinary tract, which may be related to increased medical surveillance among MS patients compared to the Danish population as a whole. There was a significant excess of nasopharyngeal carcinomas in the cohort (RR = 17.3), but based on only 3 cases and seen only among women. Hematologic and lymphatic malignancies were not increased, adding little support to previous suggestions of a possible association of these malignancies with MS. An excess of brain tumors, seen only in women, may represent situations where the tumor caused symptoms which were interpreted as MS. Overall, the data suggest that a patient with MS is not at unusual risk for subsequent cancer development, but the relatively short follow-up of the population is a limitation of the investigation.
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PMID:Cancer incidence following hospitalization for multiple sclerosis in Denmark. 195 Apr 64

The Texas Skin Cancer/Melanoma Project, cosponsored by the Texas Dermatological Society and the Texas Division of the American Cancer Society, was organized to promote awareness of skin cancer. Through a well-orchestrated effort, the citizens of Texas were educated about prevention and early detection. On one day, statewide screening was conducted at 55 sites and 11,151 patients were screened. Polls conducted before and after the project show that the level of knowledge and concern about skin cancer increased following the project. Skin cancer is ideal for such a public education and screening project.
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PMID:The Texas Skin Cancer/Melanoma Project. 196 2

The authors reviewed 874 dermatology charts to assess the acceptance rate of total skin examination (TSE), incidental skin findings, and patient compliance regarding treatment recommendations. Of the 874 new dermatology patients studied, 707 (80.9%) agreed to TSE. Important incidental findings were found in 151 (21.4%). These included: (1) biopsy specimen-confirmed malignant tumors (malignant melanoma, lentigo maligna, and basal cell and squamous cell carcinoma) in 24 of the 707 patients (3.4%), (2) biopsy specimen-confirmed premalignant tumors (actinic keratosis with dysplasia, Bowenoid actinic keratosis, Bowenoid papulosis, and lentigo with dysplasia, in five (0.7%), (3) clinically diagnosed premalignant actinic keratosis in 64 (9.1%), (4) biopsy specimen-confirmed dysplastic nevi in 17 (2.4%), and (5) congenital nevi in 41 (5.8%). Only 4.2% of the patients returned for a yearly TSE, and only 6.0% were found to follow all recommendations for monthly self examination, yearly professional examination, and sun protection. It is concluded that TSE for all new patients, and on a yearly basis for all return patients, is valuable in the detection of many skin conditions and allows skin cancer screening to be done, since patients for the most part do not follow recommendations for at-home screening.
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PMID:Yield from total skin examination and effectiveness of skin cancer awareness program. Findings in 874 new dermatology patients. 198 18

The data used for the inter-Nordic comparison of the incidence of skin cancer are based on the material of the national cancer registries of the 5 Nordic countries. It is typical of these countries that the ratio between the incidence of non-melanoma and melanoma skin cancer is much smaller than in regions near the Equator. For the detailed comparative epidemiological study of basal-cell carcinoma (BCC), squamous-cell carcinoma (SCC) and cutaneous malignant melanoma (CMM), the material from the Norwegian Cancer Registry 1955-1988 is used. The etiology of CMM has frequently been debated during recent decades. There are still some obscure points, however, particularly as regards the influence of host factors and UV exposure, and their interaction. The analysis of the incidence trend of CMM on the female breast during the time interval 1970-1988 contributes to the elucidation of these problems. Differences in the epidemiological characteristics of the 2 main types of non-melanoma skin cancer, BCC and SCC, are described. The results indicate that the effect of UV light is not a dominating for BCC as for SCC.
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PMID:The Nordic profile of skin cancer incidence. A comparative epidemiological study of the three main types of skin cancer. 198 67

Radiation exposures to the scalp during childhood for tinea capitis were associated with a fourfold increase in skin cancer, primarily basal cell carcinomas, and a threefold increase in benign skin tumors. Malignant melanoma, however, was not significantly elevated. Overall, 80 neoplasms were identified from an extensive search of the pathology logs of all major hospitals in Israel and computer linkage with the national cancer registry. Radiation dose to the scalp was computed for over 10,000 persons irradiated for ringworm (mean 7 Gy), and incidence rates were contrasted with those observed in 16,000 matched comparison subjects. The relative risk of radiogenic skin cancer did not differ significantly between men or women or by time since exposure; however, risk was greatest following exposures in early childhood. After adjusting for sex, ethnic origin, and attained age, the estimated excess relative risk was 0.7 per Gy and the average excess risk over the current follow-up was 0.31/10(4) PY-Gy. The risk per Gy of radiation-induced skin cancer was intermediate between the high risk found among whites and no risk found among blacks in a similar study conducted in New York City (Shore et al., Radiat. Res. 100, 192-204, 1984). This finding suggests the role that subsequent exposure to uv radiation likely plays in the expression of a potential radiation-induced skin malignancy.
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PMID:Radiation-induced skin carcinomas of the head and neck. 200 Apr 56

We examined data from San Francisco and other areas participating in the Surveillance, Epidemiology, and End Results (SEER) Program to determine the effect of the human immunodeficiency virus (HIV) epidemic on cancer incidence between 1973 and 1987. In this period, non-Hodgkin's lymphoma incidence has increased over 10-fold and Kaposi's sarcoma incidence has increased over 5000-fold in single San Francisco men 20 to 49 years of age. Increases in non-Hodgkin's lymphoma have been restricted to high-grade and diffuse large-cell (intermediate-grade) histological types. With the exceptions of non-Hodgkin's lymphoma and Kaposi's sarcoma, no other tumor has significantly increased in incidence. During 1987, we estimate that HIV-seropositive men in San Francisco had a 0.47% risk of developing non-Hodgkin's lymphoma and a 1.6% risk of developing Kaposi's sarcoma. The relative risks for non-Hodgkin's lymphoma and Kaposi's sarcoma associated with HIV infection were 104 and 40,000, respectively. For 1987, HIV was associated with 14% of all reported cancers (except non-melanoma skin cancer) in men aged 20 to 49. We expect that 1,890 to 2,730 excess cases of non-Hodgkin's lymphoma and 6,490 to 8,320 excess cases of Kaposi's sarcoma will occur in the United States in 1990.
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PMID:Increasing incidence of cancers associated with the human immunodeficiency virus epidemic. 200 49

Although skin cancer screening is theoretically of value, its effectiveness has not been firmly established because few studies have systematically followed persons with a positive screen to obtain pathologically confirmed diagnoses. From the 799 persons screened at Charleston Area Medical Center in 1988 and 1989, 153 screenees with suspected skin cancer, dysplastic nevi, and congenital nevi were followed to determine their final diagnosis. Follow-up was done by letter and telephone calls to both the individuals who screened positive and their treating physicians. Eighty-four (54 percent) then sought medical attention as a result of letters and calls. Thirty-one basal cell carcinomas, three squamous cell carcinomas, three dysplastic nevi, two melanomas, and one congenital nevus were pathologically confirmed. The predictive value positive of the screenings was 32 percent to 60 percent for non-melanoma skin cancer, 9 percent to 25 percent for dysplastic nevi, and 15 percent for melanoma. This study suggests that post-screening follow-up of those with suspected premalignant and malignant skin lesions is feasible and should be encouraged so that more definitive evaluation and treatment can potentially be performed and skin cancer screenings more accurately assessed.
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PMID:Preliminary results of skin cancer screening in West Virginia. 200 60


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