Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0025202 (melanoma)
 69,561 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient developed 4 separate malignancies over a 26 year period, the last of which was a primary choroidal melanoma. She demonstrated that despite previous malignancies, suspicious lesions should never be dismissed as being metastatic in origin, but should be thoroughly evaluated and treated accordingly.
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PMID:Uveal melanoma occurring as a fourth primary malignancy: case report. 45 59

A 55-year-old white woman received chemotherapy with DTIC after surgery for malignant melanoma (stage I, SSM IV, depth of invasion 12 mm). She died suddenly during the second treatment cycle. Autopsy revealed massive necrosis of the liver and thrombosis of the hepatic veins. The cause of the fatal outcome is attributed to the adverse toxic effects of DTIC.
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PMID:Hepatic failure in a patient treated with dacarbazine (DTIC) for malignant melanoma. 52 68

A melanoma of the uterine cervix, 4 mm in diameter, considered primary, in a 44-year-old pluripara is described. She was subjected to hysterectomy coupled with adnexectomy and also to BCG immunotherapy. A year following the beginning of the therapy she is without any symptom of the disease. The rarity of the tumour in this localization is pointed out, and a short review is given of the cases reported in the literature, including those of benign melanosis and "blue nevus". The histogenesis and cytologic diagnosis are discussed, as well as therapeutic possibilities. Emphasis is laid on the varying biological behaviour of the tumour which prevents the assessment of the therapy with regard to the possibility of a very late development of metastases.
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PMID:[Primary malignant melanoma of the uterine cervix]. 55 19

Bilateral uveitis, poliosis, hypomelanosis, and alopecia (Vogt-Koyanagi-Harada syndrome) developed spontaneously in a 57-year-old woman following operation for metastatic malignant melanoma. She has been disease-free for 8 1/2 years in spite of a highly unfavourable prognosis. Within the framework of current concepts of cell-mediated and humoral immunity in patients with malignant melanoma, activity of the host's immune system is postulated for the destruction of normal melanocytes in the skin, hair follicle, and uveal tract, as well as for the favorable outcome.
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PMID:Uveitis, poliosis, hypomelanosis, and alopecia in a patient with malignant melanoma. 62 81

A report rarely a case of superficial spreading melanoma of the conjunctiva bulbi in a 40-year-old woman. As this kind of tumor is very found at this site, the unusual localisation rendered the differential diagnosis more difficult and delayed the radical operative therapy. After orbitectomy the patient has been free of local metastatic deposits for two years. She is fully rehabilitated by a good epithetis. The course of diagnosis in our case illustrates the necessity of uniform application of the nomenclature of cutaneous forms of melanomas and naevi in ophthalmology.
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PMID:[Epibulbar superficial spreading melanoma (author's transl)]. 69 43

A 59-year-old woman developed a pigmented, expanding posterior pole choroidal lesion nasally that was clinically consistent with malignant melanoma. She refused enucleation, but agreed to a trial of photocoagulation therapy. Four weeks after photocoagulation, a reaccumulation of pigmentation and apparent elevation prompted a second photocoagulation treatment. During the second photocoagulation episode corneal edema occurred, and thereafter the fundus view was poor. Again, four weeks after the second treatment there appeared to be increasing pigmentation and possible elevation in the lesion centrally. Because of apparent continued growth of the tumor, the globe was enucleated 82 days after the initial photocoagulation. Serial section histopathologic examination of the lesion revealed only rare neoplastic cells along the base of the lesion. However, myriad pigment-laden macrophages were present around a central area of necrosis. Pigment accumulation within macrophages had simulated tumor growth clinically.
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PMID:Photocoagulation of malignant melanoma. 75 87

The patient was a 15-year-old girl who was found to have a amelanotic nodular melanoma on a leg. The local malignancy was widely excised and an elective lymph node dissection was performed. On microscopic examination of the removed inguinal lymph nodes, one showed metastatic involvement. She was free of obvious disease for slightly more than one year at which time a subcutaneous metastasis was found on the chest wall. Soon thereafter she suffered dissemination of malignant melanoma and, despite systemic chemotherapy, rapidly deteriorated and died of metastatic melanoma one year later. The salient features of this patient are: (1) the onset of malignant melanoma early in life (age 15); (2) the poorer prognosis of amelanotic melanoma; (3) the often hopeless situation once distant metastases appear.
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PMID:Tumor conference No. 13. Fatal amelanotic nodular melanoma in a 15-year old girl. 92 47

Two women, during pregnancy, suddenly developed changes in the pigmented skin nevus (melanoma) which they had had since their childhood. Both patients were surgically treated; the diagnosis was malignant melanoma. One of the patients, 12 years after the operation, is alive and well, and so is her child. In the other patient, 6 months after operation, there was a relapse and regional metastases. She gave birth to a healthy child.
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PMID:[Malignant melanoma of the skin and pregnancy]. 102 29

We report the case of a patient with stage 2 malignant melanoma (MM), who received a specific immunotherapy consisting of intralymphatic injections of irradiated MM cells. She developed subsequently vitiligo-like leukoderma and several plaques of localized scleroderma. Simultaneously an increase in the patient's cytotoxic activity against MM cells was detected in vitro. The responsibility of immune phenomena and specific immunotherapy for the appearance of depigmentation and morpheas is discussed.
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PMID:Vitiligo-like depigmentation and morpheas after specific intralymphatic immunotherapy for malignant melanoma. 149 95

The association between melanoma and giant congenital nevocellular nevus has been well documented, although controversy still exists regarding the precise incidence. The following patient report illustrates the excision of malignant melanoma arising from a giant congenital nevocellular nevus in a 4-month-old infant. The child had malignant melanoma with deep dermal involvement diagnosed by incisional biopsy with positive margins. She underwent subsequent en bloc resection of the original biopsy site and nevus. The reexcision specimen showed no evidence of malignancy. No adjuvant chemotherapy was used. The child is disease free at 5 years. It is possible that very young children (infants) with melanoma arising in a giant congenital nevocellular nevus may have a good prognosis.
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PMID:Malignant melanoma with evidence of maturation arising from a giant congenital nevocellular nevus. 159 74


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