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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We calculated 5-year crude and relative survival rates, by age and sex, for patients in Alberta in whom cancer was diagnosed between 1974 and 1978. Cancers with low overall 5-year relative survival rates (less than 35%) included stomach cancer, cancer of the pancreas, lung cancer, brain cancer, multiple myeloma and myeloid leukemia. Cancers with high overall 5-year relative survival rates (more than 70%) included melanoma, breast cancer, cancer of the uterus, cancer of the bladder and Hodgkin's disease. Five-year relative survival rates were generally lower in the highest age group (75 years or more). A strong inverse relation between age and survival was noted for brain cancer, non-Hodgkin's lymphoma, Hodgkin's disease and myeloid leukemia.
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PMID:Survival rates among patients with cancer in Alberta in 1974-78. 337 May 94

The relative frequency by age, sex and site of the malignant tumours diagnosed during the years 1982-84 in the main pathology department of Rwanda (serving approximately 80% of the population) is presented. Excluding skin, the numerically most important cancers in males were Kaposi's sarcoma (11.5%), stomach cancer (9.9%), non-Hodgkin's lymphoma (8.1%) and primary carcinoma of liver (6.6%), and in females cancers of the uterine cervix (21.4%), breast (16.8%) and stomach (6.5%). The possible sources of bias are discussed, and the results are compared with those from previous studies in this part of central Africa.
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PMID:[Cancer in Rwanda. Study of relative frequency]. 373 Jun 35

To evaluate occupational cancer mortality in British Columbia, we calculated the age-standardized proportional mortality ratios (PMR) and proportional cancer mortality ratios (PCMR) for 4,091 woodworkers, 5,457 loggers, 2,020 fishermen, 4,066 farmers, and 1,912 miners. Woodworkers 20-65 years old had significantly elevated risks of death from stomach cancer (PCMR = 128, P less than .01) and non-Hodgkin's lymphoma (PCMR = 140, P less than .05). Loggers appear to have an elevated risk of death from nasal sinus tumors (PCMR = 364, P less than .05). Fishermen had an elevated risk of stomach cancer (PCMR = 168, P less than .01). Farmers in British Columbia appeared to have excess risks of stomach (PCMR = 136, P less than .01) and liver cancer (PCMR = 173, P less than .05), but decreased risk from lung cancer (PCMR = 76, P less than .01). Miners had an elevated risk of death from lung cancer (PCMR = 127, P less than .05) and primary eye tumors (PCMR = 569, P less than .05).
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PMID:Cancer mortality experience of woodworkers, loggers, fishermen, farmers, and miners in British Columbia. 383 26

A multi-cancer site, multi-factor case-control study was undertaken to generate hypotheses about possible occupational carcinogens. Probing interviews were carried out with over 2,000 subjects. All incident cases of 19 sites of cancer in males aged 35-70 and resident in Montreal were eligible. The interview was designed to obtain detailed lifetime job histories, and information on potential confounders. Each job history was reviewed by a team of chemists who translated it into a history of occupational exposures. These occupational exposures were then analyzed as potential risk factors in relation to the sites of cancer included. For each site of cancer analyzed as a case series, controls were selected from among the other cancer sites in the study. This report concerns the associations between sites of cancer for which there were over 100 cases processed (stomach; colorectal, also analyzed by subsites; lung; prostate; bladder; kidney; non-Hodgkin's lymphoma) and nine organic dusts (wood; paper; grain; flour; fabrics; cotton; wool; synthetics; fur). All site-exposure combinations were investigated. The ones that provided the most interesting leads were lung-wood dust (odds ratio (OR) = 1.5), stomach-wood dust (OR = 1.5), colorectal-synthetic fiber (OR = 1.5), bladder-synthetic fiber (OR = 1.8), non-Hodgkin's lymphoma-cotton dust (OR = 1.9), colon-grain dust (OR = 2.6), prostate-grain dust (OR = 2.2), and prostate-paper dust (OR = 2.0). Only the associations with wood dust, synthetic fibers and cotton dust showed some evidence of "dose-response" with duration of exposure. Because it is such a common exposure and appears to increase lung and stomach cancer risks, wood dust may be responsible for a great deal of occupational cancer.
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PMID:Associations between several sites of cancer and nine organic dusts: results from an hypothesis-generating case-control study in Montreal, 1979-1983. 394 73

Eleven patients with spinal cord compression due to metastatic epidural tumors were analyzed. Primary tumors were Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma (two patients each), cervical cancer, malignant melanoma, gastric cancer, lung cancer, and neuroblastoma (one patient each). It was felt that myelography is the most important diagnostic test, although CT scan and bone scan may give further diagnostic information in some patients. Six patients were treated with decompressive laminectomy and postoperative radiotherapy, and five with radiotherapy alone. Regardless of the pretreatment neurological status and the type of treatment given, the functional prognosis in our small series of patients appeared to be favorable for radiosensitive tumors such as malignant lymphoma and multiple myeloma.
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PMID:[Clinical study of spinal cord compression due to metastatic epidural tumors]. 395 Nov 27

Two hundred and thirty-six cases of multiple primary cancer associated with hematological malignancies, collected from 35 medical institutions in Japan, are reported. Based on the time interval between the first cancer and the second cancer, they were divided into three groups: synchronous cancer (94 cases), metachronous cancer subsequent to hematological malignancy (61 cases) and metachronous hematological malignancy subsequent to carcinoma (76 cases). The most common initial cancers were acute leukemia (including atypical leukemia and erythroleukemia), non-Hodgkin's lymphoma, multiple myeloma and chronic myelogenous leukemia of the hematological malignancies, and gastric cancer of the carcinomas. Patients with cancer of the uterus and breast in the metachronous cancer group metachronously developed hematological malignancies more frequently than those in the synchronous cancer group. Multiple primary cancer was observed more frequently in men than in women both in the synchronous cancer group and in the group with metachronous cancer subsequent to hematological malignancies. Acute leukemia was the most frequent disease type in incidence among the metachronous hematological malignancies. This secondary acute leukemia was characterized by a mostly granulocytic nature, poor response to chemotherapy and poor prognosis.
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PMID:Multiple primary cancers associated with hematological malignancies. 400 83

We evaluated the occurrence and the type of second malignancies among 74 patients with Hodgkin's disease (HD) and 407 patients with non-Hodgkin's lymphoma (NHL) who were treated at the National Cancer Center Hospital for more than one year. Fifteen patients developed a second malignancy. In 10 of these patients the second cancer was gastric cancer, but no cases of acute nonlymphocytic leukemia were encountered. The observed number of second cancers in females among the HD patients was significantly (p less than 0.005) greater than the expected incidence based upon the number of age-adjusted person-years both for all cancers and for stomach cancer. However, no significant differences between males and females in the NHL patients were found. Furthermore, no significant differences were seen in any of the groups between the observed and expected numbers of second malignancies according to the treatment.
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PMID:Second primary malignancies in lymphoma patients. 402 Nov 22

The risk of developing a second primary cancer was evaluated in approximately 19,000 persons with initial cancers of the lymphatic and hematopoietic system in Connecticut between 1935 and 1982. Significant excesses for all second cancers were observed among patients with leukemia (34%), Hodgkin's disease (70%), non-Hodgkin's lymphoma (25%), and multiple myeloma (24%). In general, the risk of second cancers was greater in males than in females, even for cohorts not showing an excess of surveillance-related prostate cancer. Among patients with leukemia, significant excesses of cancers of the lung, kidney/ureter, and prostate were noted; cutaneous melanoma was elevated only in males. These excesses did not persist in the small number of long-term survivors. Possible etiologic factors included tobacco smoking for lung and kidney cancers, medical surveillance artifact for prostate cancer, and immunosuppression for malignant melanoma and lung cancer. The large number and good prognoses of patients with chronic lymphocytic leukemia strongly influenced the pattern of second cancers when all leukemias were analyzed together; no evidence was found for an increased risk of second cancer in patients with acute lymphocytic leukemia. A disproportionate number of subsequent cancers, particularly those of the kidney and ureter, were diagnosed incidentally at autopsy. Patients with Hodgkin's disease displayed significant excesses of cancers of the buccal cavity and pharynx, lung, female breast, and thyroid. The latter 3 sites remained significantly elevated in long-term survivors (10 yr or more postdiagnosis), so that radiation therapy may have contributed to their development. Among persons with non-Hodgkin's lymphoma, cancers of the stomach, lung, brain, and connective tissue occurred excessively. The first 3 sites, plus cancers of the urinary bladder, remained elevated among long-term survivors. The brain cancer excess, not previously reported, may represent misclassification of central nervous system lymphoma. The risk of gastric cancer is reminiscent of similar findings in patients with both acquired and genetically determined immunodeficiency disorders. The alkylating agent, cyclophosphamide, used extensively in the treatment of non-Hodgkin's lymphoma, is known to cause bladder cancer in man.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Second cancer following lymphatic and hematopoietic cancers in Connecticut, 1935-82. 408 98

Malignant lymphomas of the stomach are rare. They occur in only 1-10% of all malignancies of the stomach. They are mainly non-Hodgkin's lymphomas. Due to the rarity of the illness, the different therapy and the better prognosis, it is very important to know the appearance of the lesions in order to distinguish them from stomach cancer. Endoscopic photographs of five different cases with four primary and one secondary non-Hodgkin's lymphoma of the stomach are demonstrated and related to the classification of the macroscopic forms of sarcomas first described by Palmer in 1950 which was later confirmed for non-Hodgkin's lymphomas by Friedman. With the aid of typical endoscopic pictures we intend to make the primary unspecific changes of the mucosa of the stomach better recognizable. This is of particular importance in present times, where gastroscopic examinations are being performed to a greater extent outside endoscopic centers.
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PMID:[Endoscopic aspects of malignant non-Hodgkin lymphomas of the stomach]. 654 52

A phase II clinical trial of a new anthracycline, 4'-O-tetrahydropyranyladriamycin (THP-ADM), was performed in thirty-one patients with advanced malignant tumors refractory to standard chemotherapies. The dosage of THP-ADM was 40 mg/m2 by iv bolus injection repeated every 3 weeks. Of 3 evaluable patients with non-Hodgkin's lymphoma, one achieved partial remission. A minor response was noted in one out of 7 patients with gastric cancer and one out of 5 patients with ovarian cancer. Leukopenia less than 4 X 10(3)/cmm and thrombocytopenia less than 100 X 10(3)/cmm were seen in 81% and 19% of cases, respectively. Mild gastrointestinal toxicities including nausea and vomiting and anorexia were observed in about one third of the patients. Mild hair loss occurred in 2 patients (6%). No ECG abnormalities on clinical sign of cardiotoxicity were seen.
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PMID:[Phase II study of 4'-O-tetrahydropyranyladriamycin(THP-ADM)]. 669 55


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