Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There are several opinions which denied therapeutic effects of preoperative irradiation, however, we have obtained favorable results by preoperative irradiation for the advanced breast and stomach cancers. Because we treated them by less-fractionated irradiation method with a large dose instead of conventional fractionated one. We adopted this kind of radiation method for the purpose of enhancing the antigenicity of the cancer cells (that means to inhibit the suppression of immune reaction in hosts). Cases of advanced breast cancer were irradiated with 30 Gy at once or 10 Gy at three times a week (total 30 Gy) by betatron electron and we treated advanced stomach cancer with twice a week method (5 Gy or 3 Gy each time, total 40 Gy) by 6 MV X-ray. Cellular infiltration into the stroma of malignant tumor is able to be considered as cellular immunity of the tumor. The same reaction could be observed in radiotherapy for cancer by using above method. After preoperative irradiation, we examined the resected specimen histopathologically. Remarkable cellular infiltrations into the tumor nests, such as neutrophils, lymphocytes, macrophages and plasma cells were observed and these cellular infiltrations after the preoperative irradiation were more remarkable than the cases without radiotherapy or with conventional fractionated radiotherapy. The abscopal effects could be seen in several cases. Peripheral lymphocytes, T cells, B cells and blastoid formation rate induced by PHA in vitro were all increased after less-fractionated irradiation. The reaction to 4 kinds of immunological skin tests was also enhanced.
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PMID:[Relationship between radiotherapy and tumor immunity in hosts]. 642 95

The effectiveness of Levamisole combined with Mitomycin-C, FT-207 and PS-K for treating gastric cancer was investigated in a prospective randomized controlled study. All patients had undergone gastrectomy during the years from August 1977 to November 1980. Five year survival rates revealed no difference between groups given or not given Levamisole. In those with positive lymph node metastases plus obvious serosal invasion, there was a significant elevation in the survival rate at four years after gastrectomy. The effectiveness of Levamisole was confirmed by postoperative changes in the PPD skin test, lymphocyte blastogenesis to PHA and serum inhibition index.
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PMID:Effects of Levamisole in adjuvant immunochemotherapy for gastric cancer; a prospective randomized controlled study. 642 70

Immune complexes (IC) were measured in 66 gastric cancer patients, using the 3.5 percent polyethylene glycol (PEG) precipitation method. Preoperatively, the IC values in patients with advanced gastric cancer (stages III and IV) were significantly higher than in normal subjects (p less than 0.01). In the presence of 3.5 percent PEG-precipitated IC from sera of gastric cancer patients, the mitogen responses of normal peripheral blood lymphocytes was inhibited; the PHA response revealed a significant negative correlation with the concentration of IC (p less than 0.01). Our data suggest that IC may be a major serum factor exerting immunosuppressive effect in cancer hosts.
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PMID:Circulating immune complexes in gastric cancer patients and their effect on lymphocyte mitogenesis (the first report). 653 Aug 48

Cell-mediated systemic immunity and immuno-reactivity of the regional lymph node in patients with gastric cancer were investigated. The studies were undertaken on the parameters such as skin test (PHA, PPD, Candida and SK-SD), T-cell subpopulation and lymphocyte blast formation . And concerning the regional lymph node, percentage of T-cell and blast formation were examined. The following results were obtained. There were correlations between the nonspecific parameters (PHA skin test, count of active T-cell and PHA blast formation ) and the staging according to the Japanese Research Society for Gastric Cancer. There were also correlations between the stage and the percentage of T-cell, PHA blast formation with and without autoserum in the immunity of the proximal regional lymph node. Correlations between the PHA blast formation in the proximal lymph node and the nonspecific parameters such as PHA, Candida skin test, count of the active T-cell and PHA blast formation in the peripheral lymphocyte were observed. The immunity of the distant regional lymph node was impaired in the patients of stage IV and III with 4 metastatic lymph nodes or more. Preoperative administration of PSK prevented impairment of cell-mediated immunity after operation. Patients administrated lentinan before operation got rid of depression of immunity in the proximal regional lymph node.
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PMID:[Nonspecific cell-mediated immunity in gastric cancer patients - with special reference to immuno-reactivity of the regional lymph node and preoperative immunotherapy]. 661 95

The in vitro cell-mediated immune reactivities of mononuclear cells separated from spleen (SPL) of gastric cancer patients were studied and, these were compared to those of peripheral blood mononuclear cells (PBL) from the same patient. The level of NK activity of SPL was slightly higher than that of PBL (p less than 0.2, by paired t test), as measured by 51Cr release assay using K562 cells as target. TCGF preparations, generated in cultures of PHA stimulated SPL or PBL, were also compared by quantitative assay. SPL produced in significantly larger amounts than PBL (p less than 0.05). Then, the generation of cell-mediated cytotoxicity in mixed cell culture was investigated in both cell populations. When these cells were cultured with B-lymphoblastoid cell line Raji, SPL had much more capacity to generate cytotoxic cells, compared to PBL (p less than 0.1). Moreover, SPL had significantly increased ability of induce concomitant cytotoxicity during sensitizing to normal allogeneic PBL in mixed lymphocyte culture as compared to PBL (p less than 0.005). These results appeared to demonstrate that SPL from gastric cancer patients had much more increased in vitro cell-mediated reactivities, when compared to those of PBL from these patients.
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PMID:[NK activity, TCGF production and generation of cell-mediated cytotoxicity in spleen cells from gastric cancer patients]. 661 Jan 3

Possible substances which block the rosette formation of peripheral lymphocyte Fc-receptor to sensitized corpuscle (EA) was discovered in the serum from patients with cancer of the digestive system, and was designated as EA rosette formation inhibitor (EAI). The immunological and clinical significance of EAI was studied. Considering the activity of EAI being correlated with serum CH50 or immune complex level measured by "Raji cell method", the activity of EAI is mainly attributed to blood immune complexes. In addition, concentration of EAI was not correlated with non-specific cellular immunity. However, in the patients with high serum EAI level, the rate of peripheral lymphocytic transformation stimulated with PHA tend to be lower, but that with Con A tend to be higher. These observation suggested that suppressor T cell was activated by binding with immune complex. Serum EAI level was studied in patients with 74 gastric cancer and 70 with colon cancer before and after treatment. The results obtained revealed that EAI was frequently detected in pretreatment cases and it was decreased after operation or immunochemotherapy. Ultimately, EAI could be one of the specific parameter for diagnosis and treatment of cancer patients from immunological aspects.
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PMID:[Possible substances which block the rosette formation of peripheral lymphocyte Fc receptor to sensitized corpuscle (EA) in the serum of patients with gastric and colon cancer]. 667 81

We studied immunological significance of splenectomy in gastric cancer surgery with special reference to serum suppressor factor. The results showed that the sera from splenic venous blood in advanced gastric cancer was more suppressive to PHA blastogenesis of normal lymphocytes and also higher in the values of circulating immune complexes, as compared to the sera from peripheral blood. Furthermore, the media from cultures of spleen cells of patients with advanced gastric cancer indicated to suppress PHA blastogenesis of normal lymphocytes, as compared to the media from cultures of peripheral lymphocytes of the same patients. The suppressive activity was more increased in the media from cultures of nonadherent cell population obtained from the spleen cells. From these data, it was suggested that the spleen of patients with advanced gastric cancer was capable of producing serum suppressor factor. Therefore, gastrectomy combined with splenectomy may be reasonable in patients with advanced gastric cancer.
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PMID:[Immunological significance of splenectomy in gastric cancer surgery. Production of immunosuppressive factor in the spleen]. 667 66

Mononuclear cells and their fractions which were prepared from spleens removed at the time of surgery for gastric cancer were treated with mitomycin C and their effect on autochthonous peripheral blood lymphocyte responses to PHA-P and Con A was assessed in coculture experiments. Splenic mitomycin C treated mononuclear cells from certain gastric cancer patients were found to have suppressor activity on peripheral blood lymphocyte responses to PHA-P and Con A and the cells with the activity were either plastic dish adherent cells or T-enriched cells alone or both of them. The suppressor activity were more frequently detected in patients with stage IV disease and the patients with the activity tended to exhibit more decreased cell mediated immunocompetence than those without it. Splenic mitomycin C treated mononuclear cells from certain gastric cancer patients were also found to have augmenting activity on peripheral blood lymphocyte responses to PHA-P and the cells with the activity were either plastic dish adherent cells or T-enriched cells or all of plastic dish adherent cells and T- and B-enriched cells.
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PMID:[Effect of splenic mononuclear cells on autochthonous peripheral blood lymphocyte responses to mitogens in gastric cancer patients]. 667 67

In view of popularity of splenectomy in combination with gastrectomy for gastric cancer, immunological effect of splenectomy was studied experimentally, using SD rats and 3-methylcholanthrene-induced mammary cancer, MRMT -1. Splenectomy was performed on day -14, 2, 7, 14 or 21 of sc inoculation of 200 mg (about 4 X 10(6) cells) of MRMT -1 at the back of 4-week-old female rats. Tumor growth and immunocompetence of peripheral lymphocytes, spleen cells and thymus cells were examined. Tumor growth on day 35 tended to be inhibited in rats splenectomized on day -14, 2, or 14, while it tended to be promoted in rats splenectomized on day 7. PHA-induced blastogenesis and NK activity of spleen cells were reduced on day 2, rose on day 7 and gradually decreased on days 14 and 21. Winn's neutralization assay revealed that spleen cells on days 2, 14 and 21 of tumor inoculation had suppressor activities. In conclusion, spleen cells of tumor-bearing rats showed a reduced immunocompetence on day 2 (the early tumor-bearing stage) and on day 14 and later (the late tumor-bearing stage), while they showed a raised immunocompetence on day 7 (the middle tumor-bearing period).
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PMID:[Experimental study on immunological effect of splenectomy on tumor-bearers]. 667 70

Lymphocyte activity of patients with gastric cancer and its relation to the stage of cancer were studied. PHA response of lymphocytes from patients with gastric cancer was decreased markedly even in early stage of cancer. The PHA-stimulated lympho-cytotoxicity was not impaired in all stages of the disease. Spontaneous lymphocyte-mediated cytotoxicity showed a tendency to decrease as the cancer stage advanced. The cytotoxic activity of the supernatants from lymphocytes cultured without PHA was significantly high in the advanced stage of gastric cancer.
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PMID:In vitro lymphocyte activity: its relation to the stage of gastric cancer. 696 16


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