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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Helicobacter pylori infection, thought to be causally related to chronic gastritis, may also be associated with an increased risk of gastric cancer. To determine whether an association with gastric cancer does exist, we retrospectively evaluated serum samples from 69 patients with histologically confirmed gastric adenocarcinoma (32 with cancer at the cardia and 37 with cancer at other sites) and from 218 patients with one of three categories of nongastric cancers, with other gastric cancers, or with benign gastric neoplasms. These samples were compared with samples from 252 cancer-free control subjects, a group comprising 76 asymptomatic volunteers and 176 persons with nonmalignant disorders. Serum samples collected from cancer patients prior to surgery and from cancer-free controls were tested for antibodies to H. pylori by using a highly sensitive and specific IgG enzyme-linked immunosorbent assay. The risk of H. pylori infection in the case patients relative to the control subjects was estimated with the use of multivariate logistic regression analysis to adjust for potential confounding variables. Antibodies to H. pylori were detected in 65% of the patients with noncardia gastric cancer but in only 38% of the patients with gastric cancer located at the cardia. A significant association was found between H. pylori infection and noncardia gastric cancer (odds ratio = 2.67; 99% confidence interval = 1.01-7.06). Within the subset of patients with noncardia gastric cancer, a statistically nonsignificant tendency existed for those with the intestinal versus the diffuse histologic type of noncardia gastric cancer to have a higher risk of H. pylori infection. Our results support the hypothesis of a relationship between H. pylori infection and the development of noncardia gastric adenocarcinoma.
J Natl Cancer Inst 1991 Dec 04
PMID:Gastric adenocarcinoma and Helicobacter pylori infection. 177 May 52

The healing rate in patients with gastric cancer did not change during the last three decades despite major changes in therapeutic strategies. The internationally accepted classification allows an exact comparison between different stages of disease. The postoperative mortality has been decreased by improvement in surgical techniques and postoperative intensive care; postoperative morbidity, however, still is high depending on the extent of the surgical procedure. The type of gastric resection is determined by the localisation of the tumour. If systematic lymphadenectomy is of any benefit for the patient, is still unknown. First controlled studies do not allow any definite answer.
Chirurg 1991 Dec
PMID:[Principles of radicality in stomach carcinoma--a critical evaluation]. 177 34

Although cases of simultaneous invasive cancer of the esophagus and primary gastric cancer have been reported sporadically, the incidence of the association of superficial esophageal cancer and early gastric cancer is extremely low. In this paper we report on two cases of the rare combination of superficial squamous cell cancer of the esophagus and simultaneous early adenocarcinoma of the stomach. A total of 18 such cases in the literature are reviewed and discussed with respect to surgical procedure and the choice of alimentary tract for the reconstruction of the esophagus.
Hepatogastroenterology 1991 Dec
PMID:Simultaneous superficial squamous cell carcinoma of the esophagus and early gastric adenocarcinoma. 177 90

Japanese men in Hawaii whose ancestral roots were in Okinawa were compared to Japanese migrants from all other prefectures. The Okinawan migrants have acquired fewer cancers than men from other prefectures (P = 0.12). No one primary site accounts for this difference. Stomach cancer rates showed the largest difference between the two migrant groups. This replicates the experience of Okinawans and non-Okinawans in Japan itself. Lymphosarcoma mortality rates are much higher in Okinawa than in all Japan, but this difference is not reproduced in Hawaiian migrants. This could be explained by a post migrational decrease in HTLV-I-related acute T-cell lymphoma/leukemia. Cancer of the mouth, pharynx and esophagus has decreased in all Japanese migrants, but the decrease is much greater among Okinawan migrants, suggesting they have escaped exposure to risk factors peculiar to the Okinawan environment. Colon cancer is more common in migrant Japanese than in U.S. whites. The dramatic increase in the frequency of this tumor affects Okinawan and non-Okinawan migrants to an equal degree.
Jpn J Cancer Res 1991 Dec
PMID:Cancer incidence in Hawaiian Japanese: migrants from Okinawa compared with those from other prefectures. 177 59

Phosphotyrosine-containing proteins in various human cancer cell lines were studied by immunoblotting with anti-phosphotyrosine antibody. Of 29 cell lines derived from oral epidermoid cancer, esophageal cancer, gastric cancer, colon cancer, pancreatic cancer, hepatocellular carcinoma and malignant melanoma, 3 of the 6 gastric cancer cells showed aberrant elevation of tyrosine-specific phosphorylation. On the other hand, both esophageal cancer cells and colon cancer cells, which were reported to have amplified epidermal growth factor receptor and activated p60v-src kinase, respectively, showed no apparent elevation of tyrosine-specific phosphorylation, and their profiles of phosphorylation were similar to that of normal human fibroblasts. Two gastric cancer cells, NUGC-4 and MKN-45, showed similar profiles of phosphorylation but their responses to growth factors differed from each other. Tyrosine phosphorylation in NUGC-4 was strongly activated by treatment with epidermal growth factor and quickly reduced by the acid treatment which is effective in removing growth factors from cellular surface receptors. On the contrary, phosphorylation in MKN-45 did not respond to either growth factor or acid treatment. These results suggest that NUGC-4 and MKN-45 have tyrosine kinases which are activated by different mechanisms but share similar substrates.
Jpn J Cancer Res 1991 Dec
PMID:Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells. 177 66

An anti-human colon carcinoma monoclonal antibody 2C10 was radiolabeled with In-111 and studied in 15 patients with gastrointestinal and ovarian carcinoma. The labelling efficiency approached 100% and immunoactivity of the labeled antibody was over 75%. 2-3 mCi (1 mg) In-111-2C10 was given to the patients intravenously and scintigraphy was performed 72 hours after administration with a gamma camera. Specimens were also scanned in some of the patients. The resected tumors and remote margin were examined immunohistochemically. Positive scintigraphic images were obtained in 12/15 patients with colorectal cancer (10) and ovarian cancer (2). Negative results were seen in the two patients with gastric cancer. The scintigraphic results of 10 patients were confirmed surgically and pathologically. The remaining 5 were confirmed by endoscopy, B-ultrasonography or X-ray CT. Most patients had been definitely diagnosed before imaging except one patient with metastatic focus from ovarian cancer to colon and one with recurrent colon cancer were first detected with RIAD, showing the unique advantage the latfer. The high background radioactivity in the liver, however, is a conspicuous problem to be solved.
Chin Med J (Engl) 1991 Dec
PMID:Radioimmunolocalization of human malignant tumors with In-111 labeled monoclonal antibody. 178 19

Nitrates originating from food and particularly from water are supposedly precursors of carcinogenic N-nitroso compound (NOC) formed within the organism. According to Correa and al. these transformations could be a consequence of bacterial gastric pullulation resulting from certain hypochlorhydric conditions. Much epidemiological research has tried to establish a relationship between exposure to nitrates in drinking water and cases of gastric cancer. The present article deals with research into this relationship in France, in a region where the rate of nitrates in water supplies is among the highest. Death statistics (from cancers of the digestive and urinal tracts) are issued by INSERM and these of the population by INSEE. Towns are classified according to nitrate concentration and the number of deaths is established according to tumour detection by sex and age. Research into death rate divergencies is found by chi 2 and the correlated coefficient. The average relative risk for any age group is calculated for all types of cancer. Research on frequency is carried out from tumour records. Comparative frequency rates are established by direct standardisation according to the structural age of any one European population. Results are analysed in relation to (1) mortality rates and (2) incidence rates. (1) None of the cancers studied, of the digestive or urinary systems, whatever the age on sex, is significantly linked to the quantity of nitrates in water supplies. When all these cancers are taken into account, the death rate does not vary significantly for increasing concentration of nitrates. Towns exceeding the maximum concentration permitted by law do not have a higher mortality rate than other towns.(ABSTRACT TRUNCATED AT 250 WORDS)
Ann Gastroenterol Hepatol (Paris) 1991 Dec
PMID:[Nitrates in the drinking water and cancer]. 179 48

Gallbladder volume and contraction after a fatty meal was determined in 14 patients with gastric cancer before and 3-4 months after gastrectomy (7 total and 7 subtotal gastrectomies) with Roux-en-Y anastomosis. All patients had an increased gallbladder resting volume (p less than 0.001) and 10 of 14 patients (6 after total gastrectomy and 4 after subtotal gastrectomy) had an increased minimal residual volume after fatty meal stimulation (p less than 0.01) in the postoperative state, when compared to the preoperative values. It can be concluded that gastrectomy is followed by an impairment of gallbladder tone and contraction, both possibly increasing the risk of gallstone formation.
Ultraschall Med 1991 Dec
PMID:[Fasting volume and contractility of the gallbladder after total and subtotal gastrectomy with Y-Roux anastomosis. A prospective study]. 179 89

Recent prospective epidemiological studies have shown an association between a low prediagnostic serum selenium (Se) concentration and the risk of cancer. Se concentrations in whole blood and plasma, and the activity of red cell and plasma glutathione peroxidase (GSH-Px) were measured in patients with breast cancer, gastric cancer and colorectal cancer. The observed whole blood and plasma Se concentrations of healthy persons were 99.5 and 78.5 micrograms/L, respectively. Red cell and plasma GSH-Px activities of this group were: 21.0 U/g Hb and 256 U/L plasma. In all investigated cancer patients significantly lower whole blood and plasma Se concentrations, and significantly lower red cell and plasma GSH-Px activities were found, as compared with the values of healthy controls. Low Se concentrations of blood components may be indicative of increased cancer risk.
J Trace Elem Electrolytes Health Dis 1991 Dec
PMID:Blood selenium concentrations and glutathione peroxidase activities in patients with breast cancer and with advanced gastrointestinal cancer. 182 38

Patients who were diagnosed to have duodenal ulcer (DU) or duodenal ulcer scar (DUS) by gastric mass screening with X-Ray examination from April 1970 to Dec. 1983 were followed up to Dec. 1983 by means of record linkage to the Osaka Cancer Registry, and incident patients of gastric cancer (GC) among the study subjects during the follow-up period were investigated almost completely. Standardized incidence rates (SIR) of GC for the groups categorized by diagnosis at the initial screening, i.e., DU or DUS group and normal group, were calculated by comparing the number of GC among the study groups with the expected number of GC. This expected number was obtained by multiplying the person-year of the study subjects with GC incidence rates for the whole population of Osaka prefecture according to sex and age group. SIR were calculated by sub-groups, i.e., male and female groups, under 5 year follow-up (from the initial screening to GC diagnosis) and 5 year follow-up or over groups, and direct X-Ray examination at the detection center and indirect X-Ray examination in the screening bus groups. The results were as follows. The SIR were 0.41 for the DU or DUS group and 0.74 for the normal group. The risk for the DU or DUS group was lower than that for the normal group (R.R. = 0.55, chi 2 = 3.56, 0.1 greater than p greater than 0.05). In all subgroups, the risk of GC for each DU or DUS group was lower than that for the normal group.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Epidemiological study on the risk of gastric cancer in patients with duodenal ulcer]. 188 Sep 47


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