Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Stomach cancer mortality data were compared with dietary and biochemical data from 65 Chinese counties to provide clues to reasons for the marked geographic variation of stomach cancer mortality rates in China. Sex-specific correlation and multivariate regression analyses showed significant positive associations with consumption of salted vegetables and eggs, prevalence of antibodies to Helicobacter pylori, and levels of plasma albumin; and significant negative associations with intake of green vegetables and levels of plasma selenium and beta-carotene. Limitations of ecological data preclude causal inferences, but these findings suggest factors that may contribute to making stomach cancer the leading cause of cancer death in China and other countries.
 ...
PMID:Risk factors for stomach cancer in sixty-five Chinese counties. 130 92

Sex-specific mortality rates for selected cancer sites (including oesophagus, stomach, liver, lung, colorectum, breast and cervix) and a variety of biochemical indicators of antioxidant status, enzyme activity and oxidative stress (including plasma levels of beta-carotene, alpha-tocopherol, ascorbic acid, selenium, glutathione peroxidase, catalase, superoxide dismutase, iron, copper, zinc, total cholesterol and lipid peroxide) were examined in an ecological study of 65 mostly rural counties in the People's Republic of China. The wide range of both mortality rates and biochemical values and the measurement of a comprehensive set of biochemical indicators permitted both simple correlational and multivariate analyses of the joint and relative effects of each factor on site-specific cancer mortality. Plasma levels of dietary antioxidants were consistently negatively correlated with cancer mortality rates. Ascorbic acid was most strongly negatively associated with most cancers and selenium with oesophageal and stomach cancers. beta-carotene was found to have a protective effect independent of retinol, particularly for stomach cancer.
 ...
PMID:Antioxidant status and cancer mortality in China. 152 64

This study was performed to find out whether copper, zinc, manganese, selenium and iron concentrations in the cancerous and normal stomach tissues of the patients with stomach cancer vary within the malignant stages and Borrmann classification or not, and to investigate the interaction of copper, zinc, manganese, selenium and iron concentrations in blood of these patients. Copper concentration in cancerous tissues was not statistically significant as compared with normal tissues. Plasma and whole blood copper concentration of Stage IV showed a significant higher level than that of stage I. Zinc concentration in cancerous tissues was not statistically significant as compared with normal tissues. Selenium concentration in cancerous tissues showed a statistically significant high level as compared with that in normal tissues. Plasma selenium concentration of Stage III showed a significant lower level than that of stage I. Iron concentration in cancerous tissues showed a significantly lower level than that in normal tissues at stage IV. Whole blood iron concentration was low levels in proportion to the progress of stomach cancer. The correlation of selenium concentration between in cancerous tissues and in whole blood of these patients was significant with the correlation coefficient of 0.340. The correlation of iron concentration between in cancerous tissues and in whole blood of these patients was significant with the correlation coefficient of 0.423. The correlation between iron concentration in cancerous tissues and hemoglobin concentration in whole blood of these patients was significant with the correlation coefficient of 0.361.
 ...
PMID:[Studies on trace elements in cancerous stomach tissue of the patients with stomach cancer]. 169 39

Recent prospective epidemiological studies have shown an association between a low prediagnostic serum selenium (Se) concentration and the risk of cancer. Se concentrations in whole blood and plasma, and the activity of red cell and plasma glutathione peroxidase (GSH-Px) were measured in patients with breast cancer, gastric cancer and colorectal cancer. The observed whole blood and plasma Se concentrations of healthy persons were 99.5 and 78.5 micrograms/L, respectively. Red cell and plasma GSH-Px activities of this group were: 21.0 U/g Hb and 256 U/L plasma. In all investigated cancer patients significantly lower whole blood and plasma Se concentrations, and significantly lower red cell and plasma GSH-Px activities were found, as compared with the values of healthy controls. Low Se concentrations of blood components may be indicative of increased cancer risk.
 ...
PMID:Blood selenium concentrations and glutathione peroxidase activities in patients with breast cancer and with advanced gastrointestinal cancer. 182 38

Serum selenium concentrations were measured in 126 matched sets of cases--patients with endoscopically proven intestinal metaplasia (IM) and two different controls, matched for age (+/- 3 years) and sex. The controls were either endoscopic controls (EC) who had endoscopically proven normal stomachs or non-endoscopic controls (NC), recruited from fracture and general surgical clinics. The cases and controls were recruited from four centres in the UK. Using a paired analysis, no significant difference was seen for IM vs EC either overall or between centres. However, these findings are compatible with reports of lower serum selenium in areas with a high risk of gastric cancer provided that selenium plays its role in the later stages of the disease.
 ...
PMID:Serum selenium concentrations in patients with intestinal metaplasia and in controls. The ECP-EURONUT-IM Study Group. 184 80

An ecological survey on diet, life style and cancer mortality was carried out in 65 rural counties in China, using a questionnaire comprising 285 questions on environmental factors, dietary practices and other life style characteristics; in addition, blood, urine and food were collected and analysed. Two interpretations of preliminary data are presented. One is for the finding of a positive correlation between a latent variable, namely general nutritional status, and cancer mortality rates; the other is for a positive correlation between lipid peroxidation (plasma lipid peroxidase and copper) and oesophageal and gastric cancer mortality, and a negative correlation between dietary oxidants (plasma selenium, ascorbic acid and retinol) and mortality from oesophageal and gastric cancer.
 ...
PMID:Dietary practices and cancer mortality in China. 185 46

Trace element (TE) content (zinc, copper, selenium, chromium) in different body media during surgery and anesthesia has been studied in 56 patients with esophageal and gastric cancer. It has been established that the components of modern analgesia have different effects on intra- and extracellular zinc, copper, selenium and chromium migration. Hexenal decreases TE blood plasma level and simultaneously increases their erythrocyte concentration. The administration of the first doses of depolarizing myorelaxants causes an increase in blood plasma and a decrease in erythrocyte zinc, copper, selenium and chromium content. Subsequent doses of depolarizing myorelaxants have no such effect. The most traumatic moment of the operation is accompanied by an increase in blood plasma and a decrease in erythrocyte TE content. Upon the operation and anesthesia the TE levels under study reach baseline values. In the first 24 hours after surgical intervention there is a decrease in TE erythrocyte concentration and an increase in their blood plasma and daily urine content.
 ...
PMID:[Changes in the concentration of microelements in different body media during general anesthesia and surgery in patients with cancer of the stomach and esophagus]. 195 40

Antioxidant micronutrients are one of the body's primary defenses against free radicals and reactive oxygen molecules. Carotenoids, vitamin C, and vitamin E trap these molecules, and selenium is an essential component of an antioxidant enzyme. There is considerable support from animal studies for a protective effect of antioxidant micronutrients on cancer. However, the role of these micronutrients in cancer prevention in humans is less clear. Diet studies suggest protective effects of fruits and vegetables on risk of cancer at several sites. Inverse associations between dietary carotenoids and serum beta-carotene and lung cancer have been observed repeatedly. Vitamin C has also been consistently inversely associated with risk of oral and esophageal cancer in diet studies and with stomach cancer in both diet and plasma studies. It remains unknown, however, whether carotenoids and vitamin C or some other component of fruits and vegetables, the primary sources of these micronutrients, prevent cancer in humans. Selenium has been inversely correlated with cancers at numerous sites in ecologic studies, but observational studies do not provide strong support for a protective effect of selenium on cancer at any site. There also is not strong support for a protective effect of vitamin E on cancer in humans. Results of studies on the association of antioxidant micronutrients with cancer at many sites are inconsistent. This could be due to lack of a true protective effect or could be related to methodologic problems in assessing dietary intake in epidemiologic studies.
 ...
PMID:Antioxidant micronutrients in cancer prevention. 202 68

Selenium concentrations were measured in the serum of 244 patients attending the Norfolk and Norwich Hospital, and 246 attending the James Paget Hospital in Gorleston, Norfolk. Both the mean and the median serum selenium concentration was lower in Gorleston than in Norwich, the difference being much greater in women than in men. Whereas the selenium concentrations were normally distributed about the mean for the Norwich area, there was a skewed distribution for the Gorleston area. The results are discussed in relation to the previously observed high risk of intestinal type gastric cancer in the Gorleston area.
 ...
PMID:Serum selenium and gastric cancer in two regions of Norfolk. 272 85

Evidence pertaining to the role of dietary factors in carcinogenesis comes from both epidemiological studies and laboratory experiments. In 1982, the Committee on Diet, Nutrition, and Cancer of the National Research Council conducted a comprehensive evaluation of this evidence. That assessment as well as recent epidemiological and laboratory investigations suggest that a high fat diet is associated with increased susceptibility to cancer of different sites, particularly the breast and colon, and to a lesser extent, the prostate. Current data permit no definitive conclusions about other dietary macroconstituents including cholesterol, total caloric intake, protein, carbohydrates and total dietary fiber. Specific components of fiber, however, may have a protective effect against colon cancer. In epidemiological studies, frequent consumption of certain fruits and vegetables, especially citrus fruits and carotene-rich and cruciferous vegetables, is associated with a lower incidence of cancers at various sites. The specific components responsible for these effects are not clearly identified, although the epidemiological evidence appears to be most consistent for a protective effect of carotene on lung cancer and less so for vitamins A and C and various cancer sites. The laboratory evidence is most consistent for vitamin A deficiency and enhanced tumorigenesis, and for the ability of various nonnutritive components in cruciferous vegetables to block in-vivo carcinogenesis. The data for minerals and carcinogenesis are extremely limited, although preliminary evidence from both epidemiological and laboratory studies suggests that selenium may protect against overall cancer risk. Frequent consumption of cured, pickled, or smoked foods, possibly because they may contain nitrosamines or polycyclic aromatic hydrocarbons, appears to increase the risk of esophageal or stomach cancer, however, the specific causative agents in these foods are not clearly identified. Excessive alcohol consumption among smokers appears to be associated with an elevated risk of cancers of the oral cavity, esophagus, larynx, and respiratory tract. The mechanisms of action of dietary factors on carcinogenesis are poorly understood. The NRC committee, and more recently, the National Cancer Institute and the American Cancer Society have proposed interim dietary guidelines to lower the risk of cancer. These guidelines are consistent with general dietary recommendations proposed by U.S. government agencies for maintenance of good health.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:Diet, nutrition, and cancer. 301 Mar 79


1 2 3 4 5 6 7 Next >>