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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This report describes a 73-year-old male with early gastric cancer (type IIc) superimposed on infestation of a parasitic larva. Eosinophilic granulomas surrounding a dead worm were seen in the submucosa just beneath the intramucosal tubular adenocarcinomatous lesion measuring 1 X 1cm at the anterior wall in the acid-secreting area. The cancer cells showed lowered and altered mucin production in comparison with the surrounding non-cancerous fundic mucosa. The parasite was identified as an Anisakis-like larva by the presence of typical lateral chords. An immunohistochemical examination revealed that the cancer cells were more strongly positive for IgA and secretory component than the surrounding non-cancerous mucosa, and that IgG, IgA and IgM were detected in plasma cells around the granulomas but IgE and IgD were not. The possibility that the Anisakis-like larva preferentially infested the cancerous mucosa because of the change in mucin, local defect in acid secretion and/or other structural alterations in the area is discussed.
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PMID:Early gastric cancer superimposed on infestation of an Anisakis-like larva: a case report. 668 94

A total of 171 gastric carcinomas comprising 69 advanced cancers and 102 early cancers were examined immunohistochemically for lysozyme. Tumour cells containing lysozyme were detected in 65 cases or 38% of the 171 gastric cancer cases. The incidence of these cells did not differ remarkably by histological type and infiltrative growth of gastric carcinoma. Of the foregoing 65 cases, two well-differentiated adenocarcinomas and three signet ring cell carcinomas had numerous lysozyme-containing tumour cells, 13 had many argentaffin or argyrophil cells, and 40 had various amounts of several types of mucin. In addition, tumour cells containing both lysozyme and mucin could be identified. No correlation could be observed between lysozyme immunoreactivity in the tumour cells and cellular infiltration of granulocytes or macrophages around the tumour. The lysozyme appeared to be produced by tumour cells. The two year survival rates indicate a tendency for advanced gastric cancers containing lysozyme to have a poor prognosis.
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PMID:Lysozyme in human gastric carcinoma: a retrospective immunohistochemical study. 674 39

The "borderline lesion" of the stomach (severe dysplasia of the protruded type) is nowadays considered to be a true precancerous lesion. Histologically, this lesion is characterized by a proliferation in the area of the glandular neck, combined with severe cellular atypia. Investigation by means of transmission electron microscopy reveals the structure of these cells to be very similar to the structure of cells of an intestinal-cell-type carcinoma of the stomach. In addition to signs for a loss of differentiation of the cells, such as the absence of rough-surfaced endoplasmatic reticulum, mucin granules, and of the polarity of the cells, remarkably frequently luminal bulges and "blebs" developed to various extents can be detected. Morphometric analysis is delineating the tendency of structural features of the borderline lesion to develop toward the gastric cancer cell. These irregularities might be expressions of the beginning of expansive growth and signs pointing to differentiation into malignant neoplasia.
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PMID:On the ultrastructure of the gastric "borderline lesion". 685 92

A total of 164 gastric carcinomas comprising 97 advanced cancers and 67 early cancers were examined immunohistochemically for human chorionic gonadotropin (hCG). Tumor cells containing immunoreactive hCG was found in 7 cases or 10.4% of the early cancer cases and in 11 cases or 11.3% of the advanced cancer cases. Moreover, the incidence of hCG-beta subunit positive cells was 8.2% in the advanced cancer cases and 6.0% in the early cancer cases. The incidence of these cells did not differ significantly by histological type and by infiltrative growth of gastric carcinoma. However, hCG-containing tumor cells were frequently detected in poorly differentiated or undifferentiated area within the tumor. In addition, these cells did not contain mucin or argyrophil granules. The three year survival rates indicated a tendency for advanced gastric cancer containing hCG to have a poor prognosis.
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PMID:Human chorionic gonadotropin in human gastric carcinoma. A retrospective immunohistochemical study. 686 3

In 24 cases (5.5%) out of 438 cases of gastric cancer showing serum AFP over 20 ng/ml, 14 cases (3.2%) showed AFP positive reaction in cancer cells by immunostaining. AFP localization in cancer cells classified into marginal type, granular type, diffuse type and inclusion type. Mixed combination of these types increased in high serum AFP level. Cytomorphology of AFP positive cells was classified to clear cell type, hepatoid cell type and round cell type. Clear cell type showed endodermal sinus like pattern in histomorphology. Clear cell type and hepatoid cell type were mixed, and transient. These types showed eosinophilic hyaline like globules, poor mucin production, and rich glycogen in cytoplasm. By immunohistochemistry showed positive rate in HCG:21.4%, PLAL:50. 0%, SP1:50.0%, CK:14.3% and alpha 1-AT:92.9%, and recognized reaction of germ cell tumor (endodermal sinus tumor) marker. We thought AFP producing gastric cancer suggested differentiation to germ cell tumor (endodermal sinus tumor). The AFP-positively stained cases were found in a high age group with advanced cancer located pylorus to corpus, medullary growth pattern, and high rate in liver metastases.
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PMID:[Immunocytohistochemical studies of AFP producing gastric cancer--cytomorphology and characteristics of AFP positive cells]. 750 55

Previous studies from our laboratory have shown that benzyl-alpha-GalNAc inhibits the glycosylation of mucin in colon cancer cells. In this study, we determined whether benzyl-alpha-GalNAc inhibits mucin glycosylation in KATO III gastric cancer cells. We also examined its effects on expression of mucin antigens, and compared the mucins made by KATO III with those of a colonic cancer cell line, Caco-2. Results of these experiments suggest that benzyl-alpha-GalNAc (2 mM) inhibited [3H]glucosamine labelling of mucins by 82% in KATO III and by 70% in Caco-2. For both cell lines, the mucin secreted in the presence of benzyl-alpha-GalNAc was less acidic. Both cell lines secreted benzyl-oligosaccharides, but those from KATO III (8-9 sugars) were larger than those from Caco-2 (6-7 sugars). In mucins purified from the medium of treated cells, peripheral carbohydrate antigens (sialyl Lex in KATO III and terminal fucose in Caco-2) were decreased (compared with control), while core carbohydrate antigens (T antigen in both cell lines and sialyl Tn in Caco-2) were increased. Western blots of cell homogenates showed differences between KATO III and Caco-2 in MUC 1 apomucin protein antigens, in sialyl Lex and in sialyl Tn antigens. We conclude that benzyl-alpha-GalNAc does inhibit the glycosylation of mucin in KATO III gastric cancer cells as in human colon cancer cells, but that alterations in mucin antigens occur in a cell line-specific manner.
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PMID:Inhibition of mucin synthesis by benzyl-alpha-GalNAc in KATO III gastric cancer and Caco-2 colon cancer cells. 757 79

Intestinal metaplasia of the gastric mucosa is an important lesion in the pathogenesis of gastric cancer. The expression of a mucin-associated antigen, sialosyl-T antigen, in the tissue of gastric cancer was investigated immunohistochemically to assess its biological role. Sialosyl-T antigen, detected by the monoclonal antibody TKH2, was present in 30 (23.6 per cent) of 127 lesions, and expressed sporadically in intestinal metaplasia. Patients negative for sialosyl-T had a significantly better 5-year survival than those who were positive (70.4 per cent versus 47.2 per cent). Grading by sialosyl-T antigen expression and the DNA ploidy pattern had a predictive value for prognosis in patients with gastric cancer. The biological role of sialosyl-T antigen is not clear but the mucin alteration reflects upon the biological behaviour of gastric cancer.
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PMID:Correlation between expression of sialosyl-T antigen and survival in patients with gastric cancer. 764 20

The finding of free tumour cells within the peritoneum at the time of laparotomy for gastrointestinal cancer is an important indicator of prognosis and may help select treatment. The aim of this study was to improve the methods whereby these cells could be retrieved and identified. Free peritoneal cancer cells were found in 6 out of 18 gastric cancer patients. All 6 patients had tumour invasion through to the serosa and subsequently died of tumour recurrence. None of the 18 Dukes' B and C colorectal cancer patients had free peritoneal cancer cells. Only 2 of a further 5 patients with extensive colorectal tumour spread had positive cytologies. The conventional mucin stain Periodic Acid Schiff (after diastase digestion) and the monoclonal antibody stain B72.3 were the most useful in identifying free peritoneal cancer cells. Peritoneal brushings did not offer any advantages over conventional peritoneal washings in the retrieval of free tumour cells.
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PMID:Free peritoneal tumour cell identification in patients with gastric and colorectal cancer. 767 40

We measured the concentration and distribution of tumor associated antigens, TAG-72 and CEA, in stomach cancer by in vitro quantitative autoradiography (IV-QAR). Frozen sections of 33 specimens were incubated with varying concentrations of 125I-labeled CEA-79.1 and B72.3 antibodies specific for carcinoembryonic antigen (CEA) and tumor-associated glycoprotein-72 (TAG-72), respectively. Computer analysis of specific antibody binding gave maximal binding values which were equal to the concentrations of the antigen or epitope. TAG-72 was detected in 25 specimens, at a concentration ranging from 8.4 to 562.9 pmol/g. CEA was detected in 32 of the 33 specimens and its concentration ranged from 8.8 to 525.3 pmol/g. The distribution of TAG-72 by IV-QAR coincided with that of the tumor cells in 41.4% of the pathologic lesions. The distribution of CEA coincided with the tumor cells in 80.5% of pathologic lesions, nearly twice the TAG-72. The concentration of TAG-72 was significantly higher in mucinous adenocarcinoma and mucin containing adenocarcinomas than other types of adenocarcinomas. There was no significant difference in the concentration of CEA among the pathologic types of stomach cancer. In summary, stomach cancer exhibited wide variations in TAG-72 and CEA expression. CEA expression was more frequent and homogeneous than TAG-72.
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PMID:Concentration and distribution of tumor associated antigens TAG-72 and CEA in stomach cancer. 777 33

We succeeded in establishing a human gastric carcinoma cell line (KE-97) from oncocytes obtained from the mesentery disseminated metastatic focus of a 52-year-old male stomach cancer patient. From a histopathological point of view the gastric carcinoma was clearly a mucin-producing mucinous carcinoma, portion of which were mixed with poorly differentiated adenocarcinoma and signet-ring cell carcinoma. The oncocytes were fused into a mass and exhibited a suspended proliferating system, with a doubling time of about 28.8 hours. Transplantation of the cancer cells into skid mice resulted in a tumor system in all cases, and histologically, mucinous vacuoles were found in the cell membranes. With immunological staining they were found to be positive for anti-CEA antibodies, anti-CA19-9 antibodies and anti-ICAM-1 antibodies. Autopsy found extensive hematogenous metastasis (lung, liver) and cancerous peritonitis. KE-97 is mucinous carcinoma, and it was reported with the belief that it is a useful cell line upon the investigation of its cancer metastasis mechanism and cytological characteristics.
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PMID:[Establishment and pathological study of a new poorly differentiated mucinous gastric cancer cell line]. 786 22


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