Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The basement membrane components in the primary and metastatic lesions of 29 cases of early gastric cancer were histologically and immunohistochemically examined. On silver-impregnated specimens, reticular fibers were much more abundant in the basement membrane regions and stromal tissues in the metastatic lesions than in the primary lesions. Immunohistochemically, the basement membrane components examined, i.e. laminin, type IV collagen and fibronectin were localized much more intensely in the basement membrane and more diffusely in the stroma in the differentiated adenocarcinomas than in the undifferentiated adenocarcinomas, having a closer relationship with the rate of proliferation of reticular fibers in the differentiated adenocarcinomas than in the undifferentiated ones. Electron microscopically, laminin was also detected in the endoplasmic reticulum of differentiated adenocarcinoma cells. From these results it should be noted that the metastatic mechanism in the differentiated adenocarcinomas may be different from that in the undifferentiated adenocarcinomas of the stomach from the viewpoint of the localization pattern of basement membrane components.
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PMID:Immunohistochemical studies of basement membrane components in primary and metastatic lesions of early gastric cancer. 236 98

In brief, the clinical course of patients with Borrmann type 4 gastric cancer is characterized by its marked tendency for peritoneal metastasis (P-factor). This paper dealt with the treatment of Borrmann type 4 gastric cancer from the viewpoint of the disease P-factor, and included the following topics; UFTM chemotherapy, pharmacokinetics of mitomycin C (i.v. vs i.p. use), case presentation, Port-A-catheter (implantable drug delivery system), suppression of collagen biosynthesis, prevention of the adverse effects of mitomycin C, neochemotherapy, and autopsy findings.
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PMID:[Chemotherapy of Borrmann type 4 gastric cancer]. 301 28

The most important activity of SSM is stimulation of collagenation from cancer-infiltrated stromal tissue which confines the cancer. In order to elucidate the proliferative responses of collagen in cancer, single and double xenografts were prepared by transplantation of human gastric cancer (HGC), human lung cancer (HLC), and NB41A3 (mouse neuroblastoma) into nude mice. The collagen responses were dependent on the type of cancer cell used, particularly the cell membranes. SSM distinctly stimulated the proliferation of collagen fibers which showed a response to these cancer cells. When examined by CD, stromal collagenation was found to be dependent upon changes in the molecular structure of the cancer cell membrane. One of the glycoproteins, fibronectin, was presumed to be the most important of the substances involved.
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PMID:Antitumor effects of polysaccharides of human-type Mycobacterium tuberculosis on collagenation in human cancer xenografts. 312 16

The present study was undertaken to examine malignant alterations of collagen and elastin in human stomach cancer. Results of the study are as follows: 1. Content of hydroxyproline which in characteristic amino acid in collagen was elevated in stomach cancer tissues of Bormann types I to IV as compared to that of the uninvolved stomach. 2. When hydroxyproline content in stomach cancer of type IV (scirrhous) was compared to that in other types (I to III) of the cancer, the content in scirrhous was significantly elevated compared with that in cancers of other types, in terms of dry weight of whole tissue, number of cancer cells, and of insoluble proteins which are rich in collagen and elastin. However, when hydroxyproline was determined on two histological layers (mucosa plus submucosa layer and muscular plus serosa layer) separated from the involved and uninvolved stomach tissues, no significant difference in hydroxyproline content was observed between the scirrhous and non-scirrhous cancers. These observations may imply that an increased collagen synthesis in the scirrhous occurs in many layers of stomach tissue but is not restricted in a particular layer. 3. Non-reducing cross-link amino acids of collagen, pyridinoline and histidinoalanine, were assayed on the involved and uninvolved tissues. Pyridinoline content was higher in stomach cancers of Bormann types I to IV, while no significant difference of histidinoalanine content was found. These observations suggest that there is an increased cross-linking of collagen in stomach cancer. 4. Elastin concentration in stomach cancer was determined through the assay of desmosine and isodesmosine which are specific cross-link amino acids in elastin. The contents of these amino acids was increased in stomach cancer tissues of types I to IV as compared with that in the uninvolved tissue. 5. A ratio of desmosine plus isodesmosine to hydroxyproline was higher in the involved stomach than was in the uninvolved, suggesting that increased elastinosis exceeds collagenosis in stomach cancer.
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PMID:[Biochemical study on interstitial proteins of human gastric cancer tissue with special reference to cross-linking amino acids of collagen and elastin]. 324 67

It became increasingly evident that UFTM chemotherapy, a combination of UFT and mitomycin C is one of the most recommendable therapy for advanced gastric cancer, especially for the treatment of Borrmann type 4 gastric cancer. Objective responses were achieved in 18 out of 26 (69.2%) patients with Borrmann type 4 gastric cancer. Moreover, UFTM-Dpc treatment, a combination therapy of UFTM plus D-penicillamine (suppressor of collagen synthesis), is proposed for the treatment of Borrmann type 4 gastric cancer from the point of view of collagen synthesis inhibition. It is likely that D-penicillamine might inhibit the peritoneal metastatic involvements, which is lethal to the patients finally.
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PMID:[UFT, UFTM, and UFTM-Dpc treatment of gastric cancer]. 392 42

Since increased synthesis of collagen has been demonstrated in tissue of type IV gastric cancer, we attempted to distinguish type IV gastric cancer from other cancers by measuring serum levels of type III procollagen N-terminal peptide (type III-N-peptide). Mean serum levels in type IV gastric cancer patients without metastasis were found to be elevated above normal values and developed a tendency to be higher than those in types I, II and III gastric cancer patients without metastasis. Highly positive ratios were found in patients with liver diseases including hepatoma and colon cancer, biliary tract cancer, and esophageal cancer patients with liver, lung or bone metastasis, but only 2 out of 14 of these cancer patients without such metastasis showed positive serum levels of type III-N-peptide. Positive cases in patients with type IV gastric cancer were obtained not only in the group with clinical stage IV but also in the groups with clinical stages II and III. In addition, high serum levels of type III-N-peptide in patients with type IV gastric cancer were seen not only in the cases with liver, lung or bone metastasis but also in cases with disseminated peritoneal metastasis alone. These results suggest that if the serum level of type III-N-peptide is elevated above normal values, type IV gastric cancer should be suspected after ruling out liver diseases, myelofibrosis and liver, lung or bone metastasis.
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PMID:[Diagnostic values of serum type III procollagen N-terminal peptide in type IV gastric cancer]. 398 46

To elucidate the histogenesis of gastric scirrhous cancer, the promotion of collagen production by normal human skin fibroblasts (HSF-1) with human gastric cancer cells (KATO-III, MKN-45 and MKN-28) was investigated by direct coculture and parabiotic culture. Argyrophilic collagenous fibers were demonstrated among fibroblasts on both direct cocultures and parabiotic cultures of the fibroblasts with gastric cancer cells. Microscopic examination showed that these fibers appeared earlier and were more abundant and thicker in direct cocultures and parabiotic cultures than in single cultures of fibroblasts. Gastric cancer cells in single or parabiotic culture did not form argyrophilic fibers. For quantitative proof of the promotion of collagen production by fibroblasts with gastric cancer cells, hydroxyproline produced by fibroblasts was measured. Much higher fibroblast hydroxyproline values were obtained in parabiotic cultures with gastric cancer cell lines than in single cultures of HSF-1. Moreover, the rate of collagen synthesis by HSF-1 was much higher than that of any gastric cancer cell line tested. These results demonstrate that gastric cancer cells enhance collagen production by fibroblasts in vitro. This finding suggests that they may produce a factor promoting fibroblast collagen synthesis and that this may contribute to the formation of stromal collagen in human gastric scirrhous cancer.
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PMID:Promotion of collagen production by human fibroblasts with gastric cancer cells in vitro. 614 24

To elucidate the mechanisms of desmoplasia of gastric cancer tissues, distribution of fibronectin (FN), fibrinogen (Fbg), alpha 2-plasmin inhibitor (alpha 2PI) and factor XIII (XIIIA) in fresh 49 gastric cancer tissues and 5 gastric ulcer tissues was studied by indirect immunofluorescent technique. FN existed scarcely in the basement membrane area of gastric cancer tubuli. FN and Fbg were distributed in same patterns abundantly in the stroma of all gastric cancer tissues regardless of their histological types. Neither alpha 2PI nor XIIIA was demonstrated in gastric cancer tissues. Autofluorescence of the cross-linked collagen fibers, which were seen in many gastric cancer cases, were surrounded with FN and Fbg. These results were well identical with those obtained from gastric ulcer tissues. These facts indicate that such a mechanism as non-specific wound healing process participates in desmoplasia of gastric cancer stroma as well as in fibrosis of gastric ulcer.
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PMID:[Distribution of fibronectin and other plasma proteins in gastric cancer tissues: investigation of mechanisms of desmoplasia of the stroma]. 639 98

A 54-yr-old man was admitted to Hokkaido University Hospital, complaining of fever, multiple arthralgia, edematous erythema and face and muscular weakness of extremities during the last 2 months. He was diagnosed as dermatomyositis by acceleration of ESR, elevation of GOT, GPT, CPK, aldolase, moderate increases of collagen fibers in biopsy specimen of skin and his clinical signs. Although stools were positive for occult blood, the routine radiographic examination failed to detect the bleeding site in the upper GI. tract. However, in the double contrast picture of the stomach, a very fine abnormal linear shadow was observed at the upper corpus of the lesser curvature. This linear shadow was a margin of the tumor, retrospectively. About 4 months later, abnormal pain occurred and a mass was palpable in the left lumbar region, suggesting a pancreatic tumor. He was operated on excising the tumor, but was performed only exploratory laparotomy because of the presence of intra-abdominal metastases. Death occurred 40 days after the operation and necropsy was done. The gross anatomical findings of the abdomen showed a stomach tumor as large as an infant's head and its metastases to pancreas, lymph nodes, and greater and lesser omentum. Esophageal mucosa including esophagocardiac junction was intact. Histological examination of the intragastric tumor revealed a typical squamous cell carcinoma with keratinization. According to the absence of the components of adenocarcinoma and squamous metaplastic gastric mucosa of non-cancerous areas in the stomach, it seemed likely to be a heterotopic squamous cell carcinoma. It was unknown about the precedence between the stomach cancer and dermatomyositis. There have been 11 cases of primary pure squamous cell carcinoma in the world literature since 1968, but this is the first case report of coexistence of these two diseases.
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PMID:[A case report of a primary pure squamous cell carcinoma of the stomach associated with dermatomyositis (author's transl)]. 726 22

Tenascin, a glycoprotein of the extracellular matrix, is involved in epithelial proliferation, differentiation and cell migration during embryonic development. Later on, it is important in proliferative processes like tumor growth and wound healing. We examined the distribution of tenascin, especially in the stroma near basement membranes, in paraffin sections from 25 patients with gastric cancer by immunohistological staining with regard to tumor staging, grading and Lauren classification. In two series we used a monoclonal and a polyclonal antibody against human tenascin. In most of the sections there was a more intensive staining of the surrounding stroma in areas close to the tumor, which could indicate the direction of tumor growth. In highly differentiated tumors we found a positive, yet discontinuous staining close to the basement membrane. In contrast to this, we saw a more diffuse reaction of the stroma with network-like staining of the collagen fibres in undifferentiated tumors. In lymph nodes we also detected a small number of tumor cells by staining of the surrounding stroma.
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PMID:[Detection of tenascin in stomach cancer. An immunohistochemical study]. 752 50


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