Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 71-year-old woman underwent subtotal distal gastrectomy for II a+ II c type early cancer of the gastric antrum. Histological type was poorly differentiated adenocarcinoma with medullary proliferation, and the lesion invaded the submucosal layer. Two years and 6 months after the operation, multiple liver tumors were found on the CT scan. A surgical resection of the liver tumor was performed. Microscopically, the liver tumors were compatible with gastric cancer. The remnant liver metastases were treated by intrahepatic infusion chemotherapy with Angiotensin II human (Delivert) using a subcutaneous implanted pump. The liver metastases disappeared on the CT scan after 3 courses of chemotherapy, but bone metastasis occurred after 2 months. This mode of chemotherapy was therefore considered a useful treatment for liver metastasis in gastric cancer. We concluded that not only intrahepatic infusion chemotherapy with Angiotensin II human but also another systemic chemotherapy was necessary to treat patients with liver metastasis in gastric cancer.
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PMID:[A case of intrahepatic infusion chemotherapy with angiotensin II human for liver metastasis from early gastric cancer]. 757 90

A 69-year-old man, who had undergone distal gastrectomy for Borrmann type 3 gastric cancer two years ago, experienced a recurrence of multiple liver metastases. Then intra-arterial hepatic cannulation connecting to a subcutaneously implanted port system was indwelt via left subclavial artery. Mitomycin C (20 mg) was injected through out the induced hypertension (1.5 times of his median blood pressure) with intravenously-administered angiotensin II (Delivert), and 5-FU (250 mg/day) was continuously followed for 5 days. He received a total of five courses of this treatment every 4 to 7 weeks. The liver metastases disappeared on CT scan after 4 courses, and a complete response (CR) has been maintained with no use of other chemotherapy. The patient has obtained good quality of life for 32 months after the start of this chemotherapy. Induced hypertensive chemotherapy could be one of the effective treatments for liver metastases from gastric cancer.
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PMID:[A case of liver metastases from gastric cancer responding to induced hypertensive chemotherapy with angiotensin II]. 1043 87