Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two human gastric cancer xenograft lines (GC-YN and GC-SF) transplanted in nude mice were employed to evaluate and compare the anticancer effect of seven single anticancer agents and their various combinations. Mitomycin C, cisplatin (Briplatin) (CDDP) and 5-fluorouracil (5-FU) were screened out to be effective against GC-YN and only epirubicin (Farmorubicin) (EPIR) was effective against GC-SF. Combinations of two of these 'effective' agents revealed that FP (5-FU + CDDP) is the most effective two-agent combination regimen against both lines, and some of those 'ineffective' single agents showed synergistic effects against both lines when combined with 5-FU. Moreover, three-agent combinations composed of FP and one of the other five agents were also evaluated to select out the most effective regimen. All the combinations showed higher inhibition on the tumor growth of GC-YN than FP regimen, and FP + adriamycin (Adriacin) (ADR) and FP + EPIR were more effective against GC-SF than FP. However, taking toxic effects into consideration, the results suggest that CDDP + 5-FU + EPIR (FPEPIR) may be the regimen most worthy of clinical trial in the chemotherapy against human gastric cancer.
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PMID:Comparative study on various combination chemotherapies against human gastric cancer xenograft lines of well- and poorly-differentiated adenocarcinomas transplanted in nude mice. 180 88

Two cell lines, Kuramochi and CKS, established from human ovarian cancer, were analyzed in vitro drug sensitivity to Mitomycin C and Carboquone. These values were compared to those of eight human gastric cancer cell lines composed of various histological types. The CKS cell line, derived from serious cystadenocarcinoma, was less sensitive to both test-drugs than the groups of gastric cancer cell lines. Therapeutic indices of the two drugs were very low. So it was considered that the two drugs were unsuitable to chemotherapy to serous cystadenocarcinoma. The Kuramochi cell line, derived from undifferentiated carcinoma, was less sensitive to Mitomycin C than the groups of gastric cancer cell line. However, it was as sensitive to Carboquone as high-sensitive gastric cancer cell lines. Therapeutic index of the Carboquone in the undifferentiated carcinoma was high. So it was considered that Carboquone was suitable to chemotherapy to undifferentiated adenocarcinoma. The cytocydal actions of the two drugs were dependent upon dose and time. Time-dependency was, however, smaller in Carboquone than in Mitomycin C.
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PMID:[Quantitative analysis on in vitro drug sensitivity of cultured human ovarian cancer cell lines (author's transl)]. 706 45

cis-Diamminedichloroplatinum (II) (cisplatin, CDDP), a potent anticancer agent, was bound to the aspartic acid residues of poly(ethylene glycol)-poly(aspartic acid) (PEG-P(ASP)) block copolymer by ligand substitution reaction at the platinum atom of CDDP. The polymeric drug thus obtained was observed to form a micelle structure in aqueous medium, showing excellent water solubility. In the present study, in vitro and in vivo antitumor activity against several human tumor cell lines, toxicity and pharmacokinetic characteristics in rodents of CDDP-incorporated polymeric micelles (CDDP / m) were evaluated in comparison with those of CDDP. In vitro, CDDP / m exhibited 10 - 17% of the cytotoxicity of CDDP against human tumor cell lines. CDDP / m given by intravenous (i.v.) injection yielded higher and more sustained serum levels than CDDP. In vivo CDDP / m treatment resulted in higher and more sustained levels in tumor tissue than CDDP, and showed similar antitumor activity to CDDP against MKN 45 human gastric cancer xenograft. CDDP / m treatment caused much less renal damage than CDDP. These results indicate that CDDP / m treatment can reduce CDDP-induced nephrotoxicity without compromising the anticancer cytotoxicity of CDDP.
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PMID:Cisplatin-incorporated polymeric micelles eliminate nephrotoxicity, while maintaining antitumor activity. 1126 44