Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 67-year-old woman presented in September 1985 with productive cough, bloody sputum, and dyspnea on exertion. Productive cough and bloody sputum had developed when the patient was 55 years old. Sputum culture and radiologic findings yielded a diagnosis of nontuberculous mycobacteriosis (NTM). Antituberculous therapy with INH, RFP, and EB was initiated in November 1987 because of the development of a cavity in the right upper lobe, and led to resolution of the lesion and clinical symptoms. Despite progression of bronchiectatic changes in both lungs and a relapse of her clinical symptoms during the following 10 years, the patient retained enough pulmonary function to be able to maintain an active daily life until she died of advanced gastric cancer at the age of 79. Autopsy revealed cystic bronchiectasis accompanied by bronchial wall thickening in both lungs, with some granuloma and acid-fast-bacteria observed in lung tissue. In this report, we concluded that patients with NTM usually experience a gradual progression of symptoms and radiographic changes during their clinical course, and that their pulmonary function may be conserved well enough to maintain an active daily life.
 ...
PMID:[Nontuberculous mycobacterial infection followed for 12 years]. 1072 56

TS-1 is an oral anti-cancer agent for gastric cancer with a high response rate and low toxicity. We report a case of long-term drug retention of TS-1 causing interstitial lung disease (ILD) as a fatal adverse reaction. A 65-year-old woman underwent a total gastrectomy with pathologic confirmation of gastric adenocarcinoma. She received 6 cycles of TS-1 and low-dose cisplatin for post-operative adjuvant chemotherapy followed by single-agent maintenance therapy with TS-1. After 8 months, the patient complained of a productive cough with sputum and mild dyspnea. A pulmonary evaluation revealed diffuse ILD in the lung fields, bilaterally. In spite of discontinuing chemotherapy and the administration of corticosteroids, the pulmonary symptoms did not improve, and the patient died of pulmonary failure. TS-1-induced ILD can be caused by long-term drug retention that alters the lung parenchyma irreversibly, the outcome of which can be life-threatening. Pulmonary evaluation for early detection of disease is recommended.
 ...
PMID:Interstitial lung disease caused by TS-1: a case of long-term drug retention as a fatal adverse reaction. 2220 43

A 57-year-old man was admitted to our hospital with a high fever and productive cough. He had a previous history of total gastrectomy and splenectomy at the age of 45 years due to gastric cancer. He also showed severe macrocytic anemia with low vitamin B12, and an infiltrative shadow was found in the right lung on an X-ray. Sputum examination on admission revealed no significant pathogenic bacteria, and an acid-fast stain and a M. tuberculosis PCR test were negative. QuantiFERON TB-2G Test (QFT) was negative on admission. Because pneumococcal antigen in the urine was positive, we initially diagnosed pneumococcal pneumonia and treatment with antibiotics was started. However, symptoms were not resolved with several antibiotics, finally, a thoracoscopic lung biopsy under general anesthesia was performed for a definitive diagnosis. The biopsy showed epithelioid cell granuloma in the alveolar spaces, and the 8 weeks culture of sputum taken on admission revealed M. tuberculosis. Finally, a pulmonary tuberculosis was diagnosed and treatment with four drugs of HERZ was begun. We have encountered a case of pulmonary tuberculosis combined with a lobar pneumococcal pneumonia, and negative for QFT. In general, splenectomy is known as a risk factor of pneumococcal infection. And vitamin B12 deficiency due to gastrectomy is one of the risk factors for cellular immunity impairment and was possibly to the false negative QFT and development of TB.
 ...
PMID:A case of pulmonary tuberculosis with false negative QuantiFERON TB-2G Test. 2241 76

Pulmonary Lymphangitic Carcinomatosis (PLC) occurs in about 6-8% of patients with lung metastasis and may rarely develop in the course of gastric cancer representing a complication due to diffuse metastasis in the lymphatics of the lungs. A 29-year-old female, admitted with difficulty in breathing and productive cough for one week, was initially evaluated for respiratory tract infection. During evaluation of associated anaemia an upper gastrointestinal endoscopy showed large ulcerative growth in the lesser curvature of the stomach suggestive of carcinoma. A High Resolution Computed Tomographic (HRCT) scan of the lungs was done for evaluation of the pulmonary opacities on chest x-ray which showed nodular thickening of interlobular septa with peribronchial cuffing and fissural thickening. The biopsy of the gastric ulcer was suggestive of poorly differentiated malignancy. With the cumulative results of the investigations a diagnosis of poorly differentiated carcinoma of stomach with pulmonary metastasis as lymphangitic carcinomatosis was made. PLC is an extremely rare manifestation of metastatic gastric cancer. Though associated with an extremely poor prognosis, advanced gastric cancer in younger patients presenting with symptoms and signs of respiratory disease should alert the physician of a possible diagnosis of PLC.
 ...
PMID:A Rare Case of Pulmonary Lymphangitic Carcinomatosis in a Young Adult with Carcinoma Stomach. 2896 84