Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Among 675 patients who had undergone curative resection of gastric cancer during last 13 years, 113 died of cancer recurrence. One hundred and forty-five patients who had survived longer than 5 years were used as controls. In the recurrence group, the primary lesion was larger and the lymph node metastasis more common as compared with the surviving controls. Moreover, these lesions were often located at the upper third of the stomach and exhibited Borrmann 3 or 4 type. Prognostic serosal invasion was positive in 75 per cent of the recurrence group and negative in 84 per cent of the surviving controls. The most frequent mode of recurrence was hematogenous metastasis in negative prognostic serosal invasion (54%) and peritoneal disseminated metastasis in positive prognostic serosal invasion (52%). There were no differences in the distribution of gross and histological types of cancer in the modes of recurrence. It was found that peritoneal dissemination and/or local recurrence dominated as the mode of recurrence (51%), followed by hematogenous metastasis (34%), but that lymph node recurrence was uncommon (15%). In peritoneal disseminated cases, long-term survival following reoperation should not be expected. It was suggested that in order to improve the prognosis in the case of hematogenous metastasis, postoperative immunochemotherapy should be applied.
 ...
PMID:[Clinico-pathological study on recurrent gastric cancer after curative resection]. 283 31

An in vivo stathmokinetic method was used to analyze the mitotic activity of cancer cells from 43 gastric cancer patients. The mitotic activity was distributed between mitotic index (MI) 40.0% and MI 127.0%. The patients were classified into 3 groups; low mitotic activity (L-MA) group (MI less than 70.0%), middle mitotic activity (M-MA) group (70.0%) less than or equal to MI) 90% and high mitotic activity (H-HA) group (MI greater than 90.0%). Survival curve and average survival period were examined and compared with each of 3 mitotic activity groups. The survival curve of L-MA group was better than that of M-MA group (generalized Wilcoxon test, Z = 1.815, p less than 0.1), and the latter was significantly better than that that of H-MA group (generalized Wilcoxon test, z = 2.048, p less than 0.05). Average survival period (mean +/- S.D.) of dead patients from cancer recurrence was 24.0 months in L-MA group (n = 1), 16.1 +/- 2.4 months in M-MA group (n = 9) and 7.4 +/- 2.4 months in H-HA group (n-13). Patients with gastric cancer of high mitotic activity died earlier than patients with that of low mitotic activity in the identical histologic type, identical degree of cancer invasion and the identical stage of cancer. The results suggested that the mitotic activity of cancer cells was utilized as a new prognostic parameter of gastric cancer.
 ...
PMID:[Mitotic activity of cancer cells and survival of gastric cancer patients]. 300 74

Carcinoembryonic antigen (CEA) levels were determined in 252 gastric cancer patients. In patients with resectable cancer, the preoperative CEA values and CEA positivity rates were 2.4 +/- 1.5 ng/ml and 7.7% for stage I, 24.9 +/- 72.0 ng/ml and 10.0% for stage II, 21.6 +/- 84.1 ng/ml and 17.9% for stage III, and 6.3 +/- 8.4 ng/ml and 27.1% for stage IV cancers, respectively. In patients with nonresectable cancers, the CEA value was 83.0 +/- 235.5 ng/ml, the CEA positivity rate was 47.8%. Overall, of 252 patients with primary gastric cancer, 47(18.7%) were positive for CEA. In patients with cancer recurrence, the CEA value averaged 41.8 +/- 101.8 ng/ml, the positivity rate was 63%. This rate increased as the cancer stage increased; it was highest in gastric cancer patients with liver metastasis. In 4 of 13 patients with recurrence, an elevation in CEA was observed about 4.8 months before the clinical detection of cancer recurrence. Our results suggest that in gastric cancer patients, the preoperative and periodic postoperative assay of CEA levels has predictive value in determining cancer stage, progression and recurrence.
 ...
PMID:Carcinoembryonic antigen in gastric cancer patients. 361 14

The worldwide results of surgical adjuvant therapy for gastric cancer are reviewed. Studies from Japan suggest that earlier initiation of chemotherapy results in significantly improved survival, even in advanced resectable disease. Sites of cancer recurrence were evaluated. Transperitoneal and lymph node metastases were the major causes of treatment failure. It is suggested that these sites of recurrence be targeted in future surgical adjuvant therapy trials through preoperative, intraoperative, and early postoperative systemic and intraperitoneal therapy to control microscopic residual disease at a time when the tumor burden is the smallest.
 ...
PMID:Gastric cancer: overview of current therapies. 393 Dec 27

Recently, there is a renewed interest in the efficacy of hyperthermia in human cancer therapy. Based on the results of our experimental studies, we treated far-advanced cancer patients with extracorporeally induced total-body hyperthermia (TBHT) or continuous hyperthermic peritoneal perfusion (CHPP). In the TBHT combined with anticancer chemotherapy, a partial remission was observed in 4 (25.0%) of 16 far-advanced cancer patients. However, the improvement of survival time was unsatisfactory. The CHPP combined with anticancer chemotherapy was performed in 23 gastric cancer patients with peritoneal dissemination. In 6 of them, subjective complaints were improved, but the remarkable prolongation of survival time was not obtained. If in the future hyperthermochemotherapy is performed for cancer recurrence in early stage, more favourable results may be expected.
 ...
PMID:[Application of heat combined with antineoplastic agent administration in the treatment of cancer (with special reference to malignancy of the digestive system)]. 641 Sep 97

Among 452 patients who underwent operation for early gastric cancer, 101 were late deaths. The cause of death in these patients was studied with special reference to cancer recurrence and the occurrence of metachronous cancers in other organs. Of these 101 patients, 63 died of noncancerous diseases, the other 38 of cancer. Among the latter, 15 patients died of recurrence more than 5 years after operation; macroscopically, the protruded or elevated type combined with the depressed or excavated type were found more frequently in the primary lesions. Differentiated adenocarcinoma was a characteristic histologic findings for these lesions, and hematogenic metastasis was the most frequent recurrence pattern. Ten patients with early gastric cancer who underwent operation died of metachronous cancer in other organs. Our findings suggest that in the long-term follow-up of patients with early gastric cancer who undergo operation, the occurrence of metachronous cancer in other organs should be considered in addition to recurrence of cancer.
 ...
PMID:Cause of late postoperative death in patients with early gastric cancer with special reference to recurrence and the incidence of metachronous primary cancer in other organs. 647 56

The 5-year survival rate of gastric cancer patients was evaluated in relation to cancer infiltration to the gastric serosa, lymph node metastasis and lymph node removal, the pattern of cancer recurrence, and the presence of free cancer cells in the peritoneal cavity. The 5-year survival of patients with cancer infiltration to the gastric serosa was not improved even by more extensive lymph node removal (R3 removal) than secondary lymph node removal (R2 removal). In these patients, viable free cancer cells were detected in the peritoneal cavity. In patients with cancer recurrence, peritoneal metastasis was often present within 2 years of curative surgery. Based on our present results, we suggest that in advanced gastric cancer with marked serosal invasion, selective removal of more distant lymph nodes than secondary lymph nodes according to the location of the primary cancer lesion should be carried out in addition to R2 removal and that this selective removal is superior to uniform R3 removal.
 ...
PMID:Lymph node removal for advanced gastric cancer with special reference to peritoneal metastasis. 665 32

To evaluate whether it is appropriate to estimate the postoperative curability of gastric cancer based on the 5-year survival rate, we compared 5- and 10-year survival rates in 477 primary gastric cancer patients who had undergone gastrectomy during the 8-year period from 1960-1967. In patients who had died more than 5 years after surgery, the cause of death was investigated. The 10-year survival rate of 315 curatively operated patients was 59.1%, 2.9% lower than the 5-year survival rate. Of 176 patients who survived more than 5 years postoperatively, only 9 (5.1%) died of cancer recurrence, suggesting that the 5-year survival rate adequately reflects the curative success of gastric cancer surgery. The postoperative curability of gastric cancer is usually estimated by the 5-year survival rate. However, even in patients who survived for more than 5 years postoperatively, cancer recurrence has been observed. Therefore, we deemed it useful to assess whether it is appropriate to estimate the postoperative curability of gastric cancer based on the 5-year survival rate. From this point of view, we compared the 5- and 10-year survival rates of operated primary gastric patients and investigated the cause of death in patients who died more than 5 years postoperatively. Furthermore, in patients with cancer recurrence more than 5 years postoperatively, the pathologic findings on the cancer in the originally resected specimen were re-evaluated.
 ...
PMID:Comparison of 5- and 10-year survival rates in operated gastric cancer patients. Assessment of the 5-year survival rate as a valid indicator of postoperative curability. 705 31

Carcino-embryonic antigen (CEA) was determined in 206 patients with gastrointestinal cancer (131 colonic and 75 stomach) at the 2nd Department of Surgery of the University of Vienna. The value of CEA in predicting tumour recurrence and/or metastatic spread has been assessed within the framework of regular follow-up control examinations after surgery. A postoperative rise in CEA titre corresponded with cancer recurrence or metastasis both in patients with stomach (91%), as well as colonic cancer (86%), whilst low postoperative CEA values correlated with a negative clinical report only in patients with carcinome of the colon to any degree of accuracy (91%). The correspondence was much lower in patients with stomach cancer (67%).
 ...
PMID:[Carcino-embryonic antigen as screening protein in the follow-up of patients with surgically-treated gastrointestinal cancer (author's transl)]. 739 29

From 1966 to 1992, a total of 3,118 gastric cancer (GC) patients were referred to the First Department of Surgery, Kurume University Hospital. Fifty-six (0.02%) of these patients also had liver cirrhosis (LC). Forty-nine (87.5%) of these patients with LC underwent GC resection. Postoperative complications occurred in 32.7%, but the operative mortality rate was zero using our preoperative assessment of liver function to decide the operation. The 5-year survival rate following curative resection was 69% in early cancer and 17% in advanced cancer. Deaths were mainly cirrhosis-related in the early cancer cases, while cancer recurrence and hepatic failure were the main causes of mortality in the advanced cancer cases.
 ...
PMID:Surgical management of gastric cancer patients with liver cirrhosis. 770 54


<< Previous 1 2 3 4 5 6 7 8 Next >>