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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A population-based case-referent study provided information on the associations between several types of cancer and 12 petroleum-derived liquids. All site-exposure combinations were investigated. The most interesting results concerned the following combinations: leaded gasoline-stomach cancer, aviation gasoline-kidney cancer (and the possible implications of this association for a similar effect of unleaded automotive gasoline), mineral spirits-squamous-cell cancer of the lung, diesel fuel-nonadenocarcinoma lung cancer, lubricating oils-squamous-cell lung cancer, cutting fluids-bladder cancer, other mineral oils-bladder cancer, mineral spirits-prostate cancer, diesel fuel-prostate cancer, and lubricating oils-prostate cancer.
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PMID:Associations between several sites of cancer and twelve petroleum-derived liquids. Results from a case-referent study in Montreal. 343 51

The mortality experience of 1074 white men who retired from a United States asbestos company during the period 1941-67 and who were exposed to asbestos working as production and maintenance employees for the company is reported to the end of 1980 when 88% of this cohort was known to be dead. As noted in earlier reports the mortality for respiratory and gastrointestinal cancer was raised. A more detailed examination of causes of death shows that the excess in gastrointestinal cancer was largely due to a statistically significant excess in stomach cancer. A statistically significant excess was also noted for kidney cancer, cancer of the eye, and non-malignant respiratory disease. Eight deaths from malignant mesothelioma were observed, two of which were peritoneal. Asbestos exposures for these mesothelioma cases were low relative to other members of the cohort. Continuing follow up of this cohort shows a dose response relation for respiratory cancer that has become increasingly linear. Standardised mortality ratios peaked 10 to 15 years after retirement and were relatively constant at around 250 in each five year interval starting in 1950. This excess might have been detected as early as 1960 but certainly by 1965. The mortality experience of this cohort reflects the ultimate effects of asbestos since nearly all of the cohort has now died.
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PMID:Asbestos and cancer: a cohort followed up to death. 360 68

Cancer incidence rates for persons of Spanish surname and other Whites in the Denver, Colorado area were derived for two time periods, 1969-71 and 1979-81. The substantial deficits in total cancers for Spanish surname males and females relative to other Whites in 1969-71 diminished considerably for all age groups by 1979-81. The major determinants of this pattern were the rapidly rising Spanish surname rates for cancer of the colon and rectum, lung cancer, kidney cancer, female breast and uterine cancers, and male prostate, bladder, and hematopoietic cancers. There was a convergence of Spanish surname rates toward the other White rates for nearly all sites, regardless of whether other Whites showed increasing, decreasing, or stable rates. Notable exceptions occurred for cervical cancer, which dropped more slowly among persons of Spanish surname than among other Whites, and Spanish surname female stomach cancer rates which rose during the 1970s in contrast to a decrease among other Whites. The overall pattern is consistent with acculturation of persons of Spanish surname towards the majority's lifestyle, suggesting the value of more detailed studies of specific cancer determinants in the Spanish surname population.
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PMID:Changes in Spanish surname cancer rates relative to other whites, Denver area, 1969-71 to 1979-81. 375 22

A 46-year-old man had a general health check including an upper gastrointestinal series, gastric endoscopy and biopsy. He was diagnosed as advanced gastric cancer and hospitalized for surgery. Preoperative abdominal CT scan examination was performed, and a mass was incidentally detected in the left kidney. Further examination, ultrasound survey and selective renal angiography, confirmed a renal cancer. The patient had had no macroscopic or microscopic hematuria. Gastric resection with lymph node dissection and left nephrectomy were performed and then both cancers were radically removed. Pathologically, gastric cancer was poorly differentiated adenocarcinoma and renal cancer was carcinoma of the clear cell type.
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PMID:[A case of simultaneous surgery for primary double cancer of the stomach and kidney]. 389 79

Among 4,184 patients with cancer of the esophagus, 55 second primary cancers were observed, whereas 64 were expected [relative risk (RR) = 0.86]. The absence of an excess risk of alcohol- and tobacco-related cancers was not anticipated. A significant 19% deficit of second cancers was found among 30,843 patients with stomach cancer. Cancer of the rectum, kidney, and lung all occurred significantly below expectation. An excess risk of ovarian cancer (RR = 1.9) was seen in women. Reasons for these findings are not entirely clear. Cancer of the small intestine is rare, and despite a relatively short survival expectation, a moderate excess of second cancers was seen among 868 patients (36 vs. 26.8). Only cancers of the liver and gallbladder were significantly elevated, and the possibility of misclassified metastases is discussed. Colon cancer is one of the most common cancers in Denmark, and 29,490 patients with this disease were at slightly lower risk for development of second cancer (RR = 0.96; 95% confidence interval = 0.9-1.0) than the general Danish population, excluding secondary colon cancers. Esophageal, stomach, and liver cancers occurred less frequently than expected. That cancers of the uterine corpus and ovary were significantly increased supports the notion that common risk factors, such as diet and endogenous hormones, influence the development of these cancers. A significant 23% deficit of second cancers was also found among 26,597 patients with cancer of the rectum, excluding secondary rectal cancer. Significant deficits were seen for cancers of the stomach (RR = 0.5), lung (RR = 0.8), and brain (RR = 0.5), and for multiple myeloma (RR = 0.4). The likelihood of underreporting of second cancers, especially of the digestive system, is discussed. However, cancer of sites previously reported to be associated with rectal cancer, e.g., the colon, breast, and uterus, did not occur below expectation. Cancers of the liver and biliary tract occurred in 4,453 patients; their average survival was only 1 year. Except for a slight excess of cancer of the ovary (5 vs. 1.6), the risk of second cancer development for all sites was consistent with unity (RR = 0.90). The risk of second cancers among 7,752 persons with cancer of the pancreas was not greater than expected (88 vs. 85.2). Males were at significant risk of kidney cancer (RR = 3.2), whereas females showed elevated rates of cancers of the uterine corpus (RR = 3.2) and ovary (RR = 3.1). No site occurred significantly below expectation.
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PMID:Second cancer following cancer of the digestive system in Denmark, 1943-80. 408 3

The risk of second primary cancer was evaluated in 29,128 patients who developed tumors of the urinary tract, including benign and malignant tumors of the renal pelvis and ureter and bladder papillomas in Denmark between 1943 and 1980. Among 9,162 persons with kidney cancer, 416 developed a second primary tumor [relative risk (RR) = 1.4]. Among 19,966 persons with bladder cancer, 1,423 developed a second primary tumor against 1,239 expected (RR = 1.1). The risk of bladder cancer was increased following kidney cancer in both men (RR = 6.3) and women (RR = 10.1), and kidney cancer was increased in both men (RR = 2.9) and women (RR = 4.5) following bladder cancer. These risks were particularly pronounced for cancers occurring in the ureter and renal pelvis. Etiologic similarities are likely explanations for these observations, which also emphasize the role of host factors and the multifocal nature of urothelial tumors. A decrease in relative risks since diagnosis of the first primary cancer was seen that may partly be attributed to a lessening of the intensity of medical surveillance with time. Among long-term survivors with kidney cancer, increased risks were observed for colon and pancreatic cancers, which may be related to treatment; approximately 25% received radiotherapy. Among bladder cancer patients, increased risks of cancers of the lung and larynx occurred, probably due to tobacco smoking. A slight elevation of prostate cancer (RR = 1.3) may be attributable to medical surveillance. Unexpected findings were the significant deficits of cancers of the stomach and rectum among patients with bladder cancer and stomach cancer among those with kidney cancer.
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PMID:Second cancer following cancer of the urinary system in Denmark, 1943-80. 408 9

Clinical efficacy of new fluorouridine derivative, FF-705, was studied in 108 patients with advanced malignant tumors. Partial responses were observed in 8 of 61 evaluable cases (13.1%): 4 of 9 patients with breast cancer, 1 of 19 patients with gastric cancer, 1 of 15 patients with lung cancer, 1 of 3 patients with kidney cancer and 1 of 1 patient with pancreas cancer. In the analysis of adverse effects of FF-705, gastrointestinal toxicity was major toxicity. Especially, diarrhea was observed in 41 of 108 patients (38.0%) within a total dose of 10 g shortly after drug administration.
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PMID:[Phase II study of FF-705 by Clinical Cooperative Study Group]. 623 55

Fibrinolysis-inhibitory activity was estimated in the lysates of 21 lines of cultured human cancer cells, from which plasminogen activator activity had veen effectively eliminated by affinity chromatography. Inhibitory activity against urokinase varied from one line to another. Three lines of lung cancer and 1 line of urinary bladder cancer showed high inhibitory activity against urokinase. Two lines of lung cancer, 3 lines of gastric cancer, 1 line of renal cancer and 1 line of renal pelvic cancer showed moderate inhibitory activity. Since inhibitory activity against plasmin was not apparent in all the cell lines tested, this activity seemed to be directed selectively towards urokinase. No inhibitory activity against urokinase was detected in 4 lines of lung cancer, 5 lines of gastric cancer and 1 line of renal cancer. There was no specific correlation between the degree of inhibitory activity against urokinase and the histological cell types of the original tumors of the cultured cell lines.
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PMID:Fibrinolysis-inhibitory activity of cultured human cancer cell lines. 645 67

Mortality among 2,113 U.S. and Canadian members of the Pulp, Sulfite, and Paper Workers' Union, 1935 through 1964, was studied using a proportionate mortality analysis. Mortality due to gastric cancer was found to be elevated in all jurisdictions, but only in mills using sulfate or sulfite pulping. An excess of mortality due to kidney cancer was limited to mills in Oregon and Washington. Excesses of deaths due to leukemia, Hodgkin's disease, and lymphosarcoma were observed only in mills in Oregon, Washington, and Wisconsin and the province of Quebec. Based on small numbers, excesses of deaths due to cancers of rectum, pancreas, kidney, and lymphosarcoma were seen primarily among sulfite process workers, while Hodgkin's disease deaths occurred primarily in sulfate (kraft) process workers. These findings suggest that cancer mortality in pulp and paper workers may be related both to pulping process and to tree species processed.
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PMID:Mortality among pulp and paper workers. 650 89

Immunological similarities or differences between urokinase and plasminogen activators from 9 lines of cultured human cancer cells with varying degrees of fibrinolytic activity were examined with antibodies against human urokinase. The antibodies completely inhibited the fibrinolytic activity of 4 lines of gastric cancer, 2 lines of lung cancer, 1 line of urinary bladder cancer and 1 line of renal cancer, indicating that the plasminogen activators from these cell lines were immunologically identical to urokinase. In 5 out of these cell lines, immunological identity was also confirmed by double diffusion analysis. The plasminogen activator from 1 line of lung cancer was found to be immunologically dissimilar to urokinase by a neutralization experiment and double diffusion analysis. These findings indicate that there are at least two immunologically distinguishable forms of plasminogen activators from human cancer cells.
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PMID:Immunological analysis of plasminogen activators from cultured human cancer cells. 677 12


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