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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Surgical treatment were performed for 1190 patients with early gastric cancer at the Center for Adult Diseases, Osaka, during these 20 years. We studied on the following three clinical problems in surgical therapies for early gastric cancer; appropriate margin to resect the stomach, lymph node dissection and adjuvant chemotherapy. It is important to resect the stomach to allow an enough surgical margin, because of multiple foci and ill-defined lesion. During surgical operation special attention should be paid to multiple foci or unexpected extension of the lesion. As to lymph node dissection, N1 and N2 lymph nodes have to be removed but in elevated type lesions invading within mucosal layer, the dissection of N1 only can be permitted. Early gastric cancer patients with lymph nodes metastases had less favorable survival after surgical operation, indicating the necessity of adjuvant chemotherapy.
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PMID:[Studies on the surgical therapy of early gastric cancers]. 408 13

Of 75 consecutive inpatients with gastric carcinoma during a 3.5 year period, 40 underwent operation with the intention of cure, 5 had palliative gastric resection and 30 had exploratory celiotomy only. Early gastric cancer was found in 11 cases, that is, 15 percent of patients with gastric carcinoma or 24 percent of patients subjected to gastrectomy. The patients with early gastric cancer were operated on with the intention of cure. Comparison with a previous series from the same geographic area shows that the ratio between early gastric cancer and all gastric cancer increased significantly. This improvement in the management of patients with gastric carcinoma can be ascribed to the use of gastroscopy and biopsy. The survival rates in patients with early gastric cancer are excellent. The prognosis in patients with advanced gastric cancer, on the other hand, is poor and has remained so for the last 30 to 40 years. Twelve of the 75 patients had gastric stump carcinoma; 2 of these were early gastric cancer. Screening of asymptomatic patients for gastric cancer is at present an impossible task in most Western countries, but the risk of cancer after partial gastrectomy for benign lesions makes screening desirable in this selected group of patients.
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PMID:Relation between early and advanced gastric cancer. 615 79

Gastric cancer is one of the commonest malignancies in Singapore. 330 to 350 new cases are reported annually. Only about 8% of these cases undergo curative resection and the rest receive some form of palliative surgery. Early gastric cancer (i.e., cancer limited to mucosa and submucosa) is rarely diagnosed in Singapore. This paper presents 11 cases of early gastric cancer treated successfully by various Departments of Surgery over the past 5 years. All patients are well and free of tumour to date. The aim of this presentation is to remind clinicians of the importance of detecting early gastric cancer which has more than 90% 5 year survival rate.
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PMID:Early gastric cancer in Singapore. 620 77

Early gastric cancer (EGC) confined to mucosa and submucosa, described by Japanese physicians over 20 years ago, yields about 90% 5-year postoperative survival. EGC has been increasingly reported from centers outside Japan, but rarely from the United States. Between 1976-1981, EGC was found in six patients or about 8.5% of all gastric carcinomas diagnosed in our hospital. Diagnoses were established by following suspicious upper gastrointestinal series or negative x-rays in patients with dyspepsia by means of gastroscopy and gastroscopically obtained biopsies, brush, and/or wash cytology. All six patients underwent subtotal gastrectomy with histological findings of EGC not invading the muscularis and with no metastases. So far no tumor recurrences have been found in these six patients. The results suggest that EGC as defined by Japanese investigators occurs in our hospital and presumably across the United States more often than heretofore appreciated. Previous fatalistic attitudes toward diagnosing gastric cancer should be replaced by efforts at early diagnosis. Patients with symptoms suggestive of gastric carcinoma, including unexplained dyspepsia, should undergo early upper gastrointestinal x-ray and endoscopic examinations with biopsies and cytological tests of any suspicious raised, flat, or depressed area.
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PMID:Early gastric cancer in a United States hospital. 663 60

Although common in Japan, early gastric cancer (EGC = gastric adenocarcinoma confined to the mucosa and submucosa of the stomach, with or without regional lymph node metastases) is thought to be an infrequent occurrence in the United States. However, a review of all "curative" resections for carcinoma of the gastric body and antrum at the University of Virginia between 1974 and 1982 revealed EGC in five of 31 patients (16%). The purpose of the present study was to compare EGC to more advanced gastric cancer (ADV; n = 26) to determine whether any presenting historical, laboratory, x-ray, or endoscopic features distinguished the two groups before surgery and to ascertain whether postoperative survival in the United States mimicked the Japanese experience. All surviving patients were contacted, all charts were abstracted, all pathologic specimens were reexamined, and all radiographs were reviewed blindly by an experienced radiologist. Statistical evaluation was accomplished using Kaplan-Meier plots, chi square analysis, and unpaired "t" tests, as appropriate. At presentation, patients with EGC were younger (44 +/- 6 vs. 67 +/- 2 years, p less than 0.01) with higher admission albumin levels (4.1 +/- 0.2 vs. 3.7 +/- 0.1 mgm/dl, p less than 0.01). Although not significantly different, admission hemoglobin tended to be higher (41 +/- 2 vs. 35 +/- 2%), the incidence of weight loss tended to be less (40 vs. 65%), duration of symptoms tended to be longer (21 +/- 11 vs. 8 +/- 3 months), and tumor diameter tended to be smaller (1.7 +/- 0.6 vs. 5.8 +/- 0.7 cm) in EGC. No differences were apparent with respect to endoscopic or radiographic appearance, tumor location (greater than 70% antrum), presence of regional lymph node metastases (EGC = 2/5; ADV = 20/26), or type of resection (subtotal gastrectomy in 4/5 EGC, in 19/26 ADV). On median 5-year follow-up, however, survival with EGC has been 100%. In contrast, the Kaplan-Meier estimate of 5-year survival in ADV is 15% (42% with muscularis invasion, 0% with serosal invasion, 12% with extra-gastric spread; p less than 0.01 vs. EGC). One suture line recurrence in EGC was successfully treated by re-resection. No ADV patient with recurrence survives (p less than 0.01). Thus, EGC behaves similarly in the United States and Japan; for example, prognosis is excellent even in the presence of lymph node metastases. Inability to distinguish EGC from ADV before surgery justifies an aggressive surgical approach to all patients with resectable gastric neoplasms.
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PMID:Early gastric cancer. 672 9

Early gastric cancer (EGC) is currently defined as an adenocarcinoma limited to the mucosa or to the mucosa and submucosa with or without perigastric lymph node involvement. To evaluate the radiologic features of this tumor, the radiographs of 21 cases were reviewed. Four were Type I (protruded) tumors, eight were Type II (superficial) including two mixed lesions, and nine were Type III (excavated), containing evidence of true ulceration. A retrospective analysis of radiographic findings indicated that nine of the tumors (43%) were either suspicious or diagnostic for malignancy on at least one examination, four (19%) were thought to be benign, and eight (38%) showed no identifiable lesion in the region of the stomach subsequently shown to contain an early cancer. The location, size, histology, gross morphology, and survival data, even in the face of perigastric lymph node involvement, all suggest that the early gastric cancer reported in this and other Western series is the same as that reported by the Japanese. The data further suggest that the incidence of EGC in the West is higher than traditionally thought.
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PMID:Early gastric cancer: radiographic experience. 673 85

We investigated 81 cases resected in our department about 10 years. The following conclusions were obtained. The R2-operation in lymph node dissection should be made even for early gastric cancer. Early gastric cancer with the unclear border, uneven surface or induration should be operated as advanced cancers. Because the positive rate of lymphatic permeation in these cases is high and the hematogenous metastasis is not rarely found. We also sent out a questionnaire to 430 hospitals which were attached to the Japanese Research Society for gastric cancer. We do believed that we should not easily performed the non operative treatment for early gastric cancer, because we could be only obtained the exact information after the histological examination of resected specimens.
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PMID:[Problems and present status of surgical treatment for early gastric cancer]. 674 37

Early gastric cancer confined to the mucosa or submucosa, similar to that described in the Japanese literature, exists in Newfoundland, on area of North America in which gastric cancer is four times more prevalent that on the rest of the continent. If untreated, this early gastric cancer will progress to advanced disease. The clinical presentation of 10 patients suffering from cancer confined to the mucosa and submucosa of the stomach is described. The disease presents with acute or chronic bleeding or unexplained dyspepsia; no abnormality of the stomach can be seen on roentgenograms. The diagnosis may be suspected at endoscopic examination. Cytologic studies using touch preparations may be suggestive but the diagnosis should be confirmed by biopsy before operation is performed.
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PMID:Early gastric cancer. 705 71

Gastric Cancer comprises two basic types: Advanced Gastric Cancer (A.G.C.) and Early Gastric Cancer (E.G.C.). A.G.C. extends beyond the proper muscle layer with a 5 to 17%, five years survival rate after surgery. E.G.C. does not extend beyond the submucosa (with or without metastasis to regional lymph nodes) and has a 80 - 95% five years survival rate. Intermediate Gastric Cancer, PM G.C. (Gastric cancer of the proper muscle layer) does not surpass the proper muscle layer and offers a five years life expectance of near 60% after adequate surgical treatment, with peculiar features in radiology, endoscopy and evolutivity. We report a case of PM G.C., "depressed" and "protruded". The proper muscle layer was invaded by the depressed lesion". Both lesions were continguous.
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PMID:[Intermediate gastric cancer]. 721 Nov 31

In order to improve the prognosis of gastric cancer it is necessary to discover the lesions at an early stage of the disease. Early gastric cancer has an excellent prognosis with a postoperative survival rate of 77 to 99%. Since 1970 we have diagnosed 76 cases of early gastric cancer and the percentage of early cancer out of all gastric cancers increased from 10 to 23%. This improvement is based on selected examinations of high-risk patients, on better diagnostic methods and on our better knowledge of macroscopic and histological appearance. In particular, the use of snare biopsy in protruding lesions and the implementation of continuous endoscopic-bioptic follow-up of all gastric ulcers until complete healing is achieved have improved the accuracy of histological verification. In 16 out of 76 cases of early gastric cancer a multicentric growth was observed. The diagnosis of gastric cancer at an early stage is not an utopian idea. It is reality when we pay attention to the aspects mentioned before.
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PMID:[Early diagnosis of gastric cancer, a utopian idea? (author's transl)]. 725 22


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