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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Among 2003 gastric specimens from 301 patients, diagnosis for carcinoma was made in 45 cases. Examination of resection preparations revealed 36 cases of deep invasive stomach carcinoma and 9 cases of early gastric cancer confined to mucosa and/or submucosa. Carcinomatous proliferations limited to mucosa or submucosa are classified in three histologic types: intestinal (adeno), mucocellular (signet ring cell), and anaplastic (solid) type of early gastric cancer. Mixed types have been found combining the first and the second, or the second and the third type. One case presented a mixture of all three types. Possible precursor or initial stages of all three types were found in further 31 biopsies. Some of them were glandular lesions in superficial parts of the mucosa; this kind has been described previously as possible preneoplastic stage of the intestinal type of early gastric cancer. "Signet ring cell drippings" from lower parts of tubule necks were recorded as an initial form of the signet ring cell type. The process is interpreted as detaching of isolated signet ring cells from a gland neck zone in progressing atypical transformation. An early neoplastic stage of the anaplastic (solid) type of early gastric cancer is identified in the "gland neck dysplasia" located exclusively in the antrum between surface mucosa and antrum glands. This lesion appears rich in cells and stretched like a broad ribbon. Early gastric cancer of this third type will arise in the very same location. Conclusions from formal histogenesis suggest that the signet ring cell type and the anaplastic (solid) type of early gastric cancer might start in the lower part of tubule necks. In consequence, the neck region of gastric glands could be the critical field of malignant transformation in the gastric mucosa. Long-term follow-up studies will be needed to verify these observations and their interpretation.
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PMID:Histologic types and possible initial stages in early gastric carcinoma. 16 8

Early gastric cancer is being encountered with increasing frequency in Germany as well as Japan and elsewhere through greater awareness, selection of high risk patients and improved diagnostic methods. We consider endoscopy superior to radiology in the detection of early gastric cancer. Polypoid lesions of the stomach need endoscopic biopsy or removal for proper diagnosis. Gastric ulcers should be followed by endoscopy and guided biopsies until healing is complete. Adequate sampling of a suspected gastric lesion may require multiple biopsy specimens for accurate histological interpretation.
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PMID:Diagnosis of early gastric cancer. 45 53

Early gastric cancers of 300 patients were evaluated using the Lauren approach of histological classification, that is to say distinguishing between a diffuse and an intestinal type of cancer. It turned out, that the role of gastritis in the pathogenesis of early gastric cancer is rather ill defined. A high percentage of early cancers of the diffuse type were found in gastric mucosa showing no inflammatory changes whatsoever. From the point of view of pathogenesis both types of cancer have to be considered as separate nosological entities. This difference is most obvious during the early stages of development. Therapeutical consequences will certainly have to be drawn in the future from this subdivision for patients at risque. Early gastric cancer presents in a high percentage of cases at first as an ulcerative lesion; this stresses the importance of careful gastroscopic and bioptic examination of patients with gastric ulcera, and of frequent examinations of these patients.
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PMID:[Histological classification of early gastric cancer in 300 cases - clinical significance (author's transl)]. 73 8

After having asserted the still rising interest for an as early as possible diagnosis of gastric cancer, authors refer on a group of patients who are carriers of Early gastric cancer. After having touched upon localization and histological characteristics of neoplasms, linger on the rules that leaded their therapeutic choice and they report the results of a follow-up dragged ten years long. They terminate affirming only a timeliness diagnosis can consent a really decisive therapeutic approach.
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PMID:[Anatomo-clinical considerations on early gastric cancer]. 129 Mar 67

A cooperative study involving 13 hospitals in Chile allowed the analysis of 353 patients with gastric cancer in early stages. 82 cancers were located at the mucosal level, 151 at the submucosa and 120 reached the muscular layer. There were no differences in age and sex among these groups. Compared to early stage, patients with intermediate stage had a greater incidence of bleeding, anemia and undernutrition and exhibited lower body weight. Endoscopy had a higher diagnostic yield compared to radiological study. The diagnosis was confirmed by biopsy in 95% of patients. Total or subtotal gastrectomy was performed according to the location of the lesion, with a low operative mortality rate. Early gastric cancer accounts for 8 to 10% of all patients with gastric cancer undergoing surgical treatment.
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PMID:[A cooperative study on early and intermediate gastric cancer: clinical, diagnostic and therapeutic aspects]. 134 May 69

Although there is a decreasing number of gastric cancer patients in Japan, the number of patients over 80 years of age is increasing. Forty patients over 80 years of age (from 80 to 88 years) with gastric cancer (Group 1) during the 10 years from 1980 to 1989 were retrospectively investigated and compared with those 70-79 years of age (Group 2). The resectability rate was 80% in Group 1 and 89% in Group 2. Early gastric cancer was observed at a rate of only 25% in Group 1 and 39% in Group 2. Pathologically, the differentiated type occurred in 78% of those in Group 1 and 68% of Group 2. Total gastrectomy was performed in only 6% of the resected cases in Group 1 and in 25% of Group 2. A combined resection including such operations as pancreatico-splenectomy or splenectomy (PS) was employed in none of the total gastrectomy cases in Group 1 and in 30% of Group 2. R3 gastrectomy was performed in none of the patients in Group 1 and in 21% of those in Group 2. Postoperative complications occurred in 25% of Group 1 patients and in 12% of Group 2 patients. Anastomotic leakage occurred in 3% of those in Group 1 and in 4% of those in Group 2. The 5-year survival rate was 47% for all the resected cases in Group 1 and 68% for Group 2. The 5-year survival rate was 61% for those who underwent a curative (radical) gastrectomy in Group 1, and 84% for those in Group 2.
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PMID:Gastric cancer surgery in the elderly. 140 37

The "revisionist" approach to therapy of gastric cancer needs a previous demonstration of the qualitative comparability of Japanese and western treatments of gastric adenocarcinoma. Early gastric cancer is far more common in Japanese than in Occidentals, but its character is the same, and for identical stages and treatments, the prognosis is the same. But many western studies show serious methodological deficiencies (staging, anatomopathological examination...), as well as a serious lack of interest in adjuvant therapy, a potential source of progress. We propose a 4-point therapeutic approach inspired by the Japanese example: a greater methodological rigor, standardization of lymphadenectomies, the definition of therapeutic subgroups to receive optimal treatments, the development of new adjuvant treatments.
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PMID:[Cancer of the stomach: for a revised strategy]. 145 85

Early gastric cancer is a unique form of gastric carcinoma with an excellent prognosis. Now recognized worldwide, this tumor is most commonly diagnosed in Japan secondary to aggressive screening practices. Early detection is dependent on a low threshold for esophagogastroduodenoscopy with biopsies, because specific symptoms and physical findings or diagnostic laboratory tests are rarely present with early gastric cancer. Once the disease is diagnosed, subtotal gastrectomy achieves survival rates equivalent to those of age-matched controls. Consideration of total gastrectomy is warranted with proximal tumor location or multicentric carcinoma. Radical lymphadenectomy should be undertaken in patients with regional nodal metastasis. After operative resection, patient outcome is usually excellent. Large submucosal tumors with an aneuploid DNA pattern and nodal involvement denote a more ominous outlook. Close patient follow-up is necessary to detect both the uncommon recurrence and the more common nongastric malignancy.
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PMID:Early gastric cancer. 154

Early gastric cancer (EGC) was diagnosed in only a small percentage (less than 1%) of gastric cancer cases seen at Tygerberg Hospital over a 10-year period (1976-1985). This study, aimed at increasing the yield of EGC, was conducted in some high-incidence areas for gastric cancer. Coloured men, who are at high risk for gastric cancer, were identified by their medical practitioners and investigated. A total of 272 coloured males with nonspecific foregut symptoms underwent upper gastro-intestinal endoscopy and multiple biopsy specimens were obtained from all localised mucosal lesions. Twelve gastric cancers were histologically verified, of which 11 were diagnosed in males over 40 years of age. Two EGCs were diagnosed in older males, resulting in a markedly higher proportion of EGC in this subgroup (18.2%) than the proportion of EGC in inpatients at our institution (0.9%). Twenty-two per cent of males over 40 years of age had gastric ulcers compared with 9.2% of younger males. Chronic atrophic gastritis was present in 56.2% of older males but in only 24.6% of younger males. Those over 40 years of age emerged as a subgroup with a high prevalence of gastric cancer and EGC, and concomitant conditions.
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PMID:Endoscopic investigation for gastric cancer in a high-risk group. 156 12

From 1965 to 1983, 1362 patients with primary gastric cancer and no other evidence of a malignancy underwent gastric resection in the Second Department of Surgery, Kyushu University. Of these, 117 patients (8.6%) with gastric cancer invading the muscularis propria (pm) were studied clinicopathologically with special reference to the macroscopic appearance: Borrmann type cancer or advanced gastric cancer simulating early gastric cancer (AGC simulating EGC). The Borrmann type cancer comprised 62.4% (73/117) of cases and the AGC simulating EGC comprised 37.6% (44/117). The survival rate for patients with the Borrmann type cancer was lower than in cases of AGC simulating EGC (P less than 0.01). The 10-year survival rate was 82.6% for patients with AGC simulating EGC and 60.5% for those with Borrmann type cancer. A multivariate analysis showed that operative curability and lymph node metastasis are significant prognostic factors and these events differed between the Borrmann type cancer and AGC simulating EGC and the survival rate for patients with the Borrmann type cancer was less favorable. Our findings show that the lymph node dissection is important for the operative curability of pm gastric cancer with the Borrmann type. Postoperative chemotherapy is required in cases of a non-curative resection.
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PMID:Gastric carcinoma invading muscularis propria and macroscopic appearance. 158 6


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