Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We evaluated 58 patients who were still alive more than ten years after operative treatment of gastric cancer. We reexamined their histologic specimens and compared them with those of matched paired controls of the same sex and age who had died of gastric cancer. Forty-two patients consented to a follow-up study. The age of the patients did not affect survival. For patients with gastric cancer, those with distal cancer or an ulcer simulating cancer had had a better prognosis. Forty percent of the patients had had an early gastric cancer. Only two patients had had lymph node metastases in regional lymph nodes, and macroscopic tumor growth through the serosa had been recorded in only four cases. In 23 cases, a distal resection had proved successful. No significant correlation between intestinal or diffuse types of cancer and prognosis was observed. One recurrence after ten years was found; in one case, there was a new cancer in the gastric remnant. In addition, biopsy specimens from two patients showed grave dysplasia. We suggest that throughout their lives annual follow-up examinations be performed in patients who have undergone radical operations for gastric cancer.
 ...
PMID:Analysis of 58 patients surviving more than ten years after operative treatment of gastric cancer. 361 19

Follow-up of patients operated on for gastric ulcer--137 with selective gastric vagotomy (SGV), pyloroplasty and ulcer excision (1967-1976) and 72 with proximal gastric vagotomy (PGV) and ulcer excision (1974-1984)--was supplemented with data from recent clinical, endoscopic and biopsy studies in 78 of the patients. Ulcer recurred in 27/137 SGV and 7/72 PGV cases (20.3 and 9.9%). Four patients died of gastric cancer 5-7 years after SGV. Of the endoscopically reexamined patients, 1/42 with SGV and 1/36 with PGV were found to have asymptomatic ulcer. The incidence of gastric stasis with food retention was 35.7% in the SGV, and 8.3% in the PGV group, and the respective incidences of severe gastric mucosal inflammation with fibrinous deposits were 42.9% and 2.7%. Mild or moderate dysplasia was shown in biopsies from 16.6% of the SGV and 8.3% of the PGV group. The high dysplasia incidence, especially after SGV, and the four gastric cancer deaths in that group indicate a need for long-term follow-up evaluation of possibly increased gastric cancer risk following vagotomy.
 ...
PMID:An endoscopic study of ulcer recurrence and mucosal changes following vagotomy and excision of gastric ulcer. 363 May 28

A comparative evaluation of microscopic features of gastric mucosa in patients with stomach cancer and non-tumor controls showed the incidence of atrophic-hyperplastic gastritis and degree III gastric mucosa cell dysplasia in the former group to be 24.8 and 7 times that in controls, respectively. The data obtained suggest the said non-tumor pathology to be factors of risk for stomach cancer development.
 ...
PMID:[Morphological criteria of the risk of stomach cancer in gastritis patients]. 366 Jul 55

To evaluate the clinical and biological significance of gastric dysplasia, we reviewed the histology of all available specimens of gastric mucosa in 85 patients in whom dysplasia had been previously diagnosed. The initial diagnosis of dysplasia was mild (Dy I) in 23 cases, moderate (Dy II) in 41 cases, and severe (Dy III) in 21 cases. The length of follow-up varied from 3 months to 11 years, with an average of 42 months. The follow-up of cases with Dy I and Dy II suggests that both lesions progress slowly and in most instances will remain stable or regress. In 18 cases, a carcinoma was found--17 in the group of Dy III and one in the group of Dy II. Of the 18 carcinomas, nine were at an early stage. Our data suggest that severe dysplasia is a reliable marker of high risk of gastric cancer and represents a strong indication for a gastrectomy.
 ...
PMID:Gastric dysplasia. A histological follow-up study. 366 23

The risk of developing gastric cancer has been investigated in a case-control study and in a prospective investigation. In the case-control study, 1495 cases of gastric cancer were identified in five city hospitals and matched with autopsy controls from the same hospitals. The frequency of operations for benign ulcer [partial gastrectomy (PG) and gastroenterostomy] was similar in the two groups. Thus, there was no increased risk for late gastric cancer after an ulcer operation. A total of 140 operated ulcer subjects [80 truncal vagotomy and drainage (TVD), 60 PG and 78 nonoperated cases attending with dyspepsia (C)] were examined by endoscopy, multiple gastric biopsy and analysis of gastric juice for nitrite. Biopsies were graded for gastritis and a gastritis index was derived (normal, 1; superficial gastritis, 2; chronic atrophic gastritis: mild, 3; moderate, 4; severe, 5). More atrophic gastritis was found in operated subjects than in controls: TVD, 2.3 +/- 0.08 (mean +/- SE); PG, 2.6 +/- 0.1 versus C, 1.8 +/- 0.08, p less than 0.01. The severity of atrophic gastritis increased after an operation interval of 20 years in PG subjects (p less than 0.05). Intestinal metaplasia was a common change, but unequivocal epithelial dysplasia was not observed. Two cases of operated stomach cancer were found. High levels of nitrite were positively correlated with pH and a high gastritis index. This evidence does not suggest that ulcer surgery leads to either an increased risk of cancer or a precancerous condition.
 ...
PMID:An investigation of possible risk factors associated with gastric cancer after benign ulcer operations. 367 37

One hundred and forty-four patients with apparently benign gastric ulcer were endoscopically followed up in order to evaluate the outcome of the lesion. Particular attention was given to: (a) detect possible delay in diagnosing gastric cancer; (b) ascertain the frequency of association with epithelial dysplasia; (c) establish the role of markers, such as serum pepsinogen group I (PGI), and gastric juice CEA in predicting gastric ulcer evolution. Endoscopic and bioptic check-ups were carried out during the first year at 3, 6 and 12 months after endoscopic healing of the ulcer, and then at every symptomatic recurrence. Ten patients (6.9%) were found to present histological evidence of malignancy (within 3 months in six cases, between 6 and 12 months in three cases, and after 41 months in the rest). Four cases were early gastric cancers, and six had shown dysplastic changes of the mucosa at the edge or scar of the ulcer. Serum PGI levels were not significantly different in gastric cancer patients, while gastric juice CEA levels were sharply increased compared to those of gastric ulcer patients: nine out of ten patients had values above normal range. These data suggest that: (a) there may be some delay in diagnosing gastric carcinoma, and gastric ulcer patients should be controlled routinely more than once; (b) the presence of dysplasia indicates the need for prolonged follow-up, because of the high risk of association with or evolution into gastric cancer, and because of the higher number of early gastric cancer detections that this protocol allows; (c) further support in monitoring patients "at risk" may be afforded by gastric juice CEA determination.
 ...
PMID:Early and advanced gastric cancer during follow-up of apparently benign gastric ulcer: significance of the presence of epithelial dysplasia. 369 32

Sera were collected in a high-risk area for stomach cancer in Colombia from 857 residents who had been gastroscoped. The levels of 6 micronutrients (retinol, beta-carotene, ascorbic acid, vitamin E, prealbumin, retinol-binding protein) were measured and the mean values correlated with the presence of gastric pathology thought to represent precursors of stomach cancer. Two micronutrients showed important variations in mean levels by gastric pathology: beta-carotene and vitamin E. Beta-carotene levels were low in patients with dysplasia, but no differences were detected for retinol levels.
 ...
PMID:Correlations of values of micronutrients in sera with gastric pathology. 383 20

There have been recent findings of gastric cancer in patients treated with cimetidine but too soon after treatment for that drug to have had a pathogenetic role. Ranitidine has been shown to induce slight changes in the gastric mucosa. In 117 patients with gastric ulcer followed-up in some cases for 24 months, five cases of cancer were detected, one after more than a year of follow-up. The numbers were too small to allow any conclusion to be drawn regarding relationships with medication. No significant differences in incidence of gastric epithelial dysplasia between control patients and patients treated with cimetidine or ranitidine were found. No dysplastic lesions were seen during a brief follow-up of 19 duodenal ulcer patients and a few gastric ulcer patients treated with pirenzepine but the data is too limited to allow conclusions to be drawn.
 ...
PMID:The risk of gastric dysplasia in medical long-term treatment of peptic ulcer disease. 385 10

Thirty five patients with early gastric cancer have been treated at the Bristol Royal Infirmary since 1965. The number of cases diagnosed has doubled in the last 10 years. Epigastric pain (74%), loss of weight (63%), and gastrointestinal bleeding (43%) were the most common presenting symptoms, with a median length of history of 12 months (range five days to 72 months). Life table survival curves showed a crude five year survival of 71% (age adjusted 92%) and a crude 10 year survival of 63% (age adjusted 85%). Sixteen patients have been followed up clinically, endoscopically, and by scintigraphy with technetium-99m p-butyl iminodiacetic acid to assess the risk of recurrent disease. Of seven patients with pronounced bile reflux, two had moderate dysplasia of the gastric remnant, and one patient was found to have developed a metachronous tumour nine years after surgery. Partial resection seems to be the best choice of treatment for early gastric cancer, giving good functional results. Consideration should, however, be given to Roux en Y diversion, and long term surveillance of the gastric remnant is recommended.
 ...
PMID:Early gastric cancer: the case for long term surveillance. 392 68

Recent developments in the epidemiology of gastric cancer have direct clinical implications: It is important to classify patients as belonging to communities with high or low gastric cancer risk. Most native white Americans are at low risk. American Indians, blacks, and Hispanics, as well as immigrants from Russia, Scandinavia, Japan, and some Latin American countries, are at high risk. In high-risk populations the predominant histologic type of gastric carcinoma is "intestinal" or "expansive" which tends to form discrete masses, predominates in males and older people, and has a relative better prognosis. In low-risk populations the tumors tend to be "diffuse" or "infiltrative," are frequent in females and younger people, and tend to have a worse prognosis. The intestinal type of gastric cancer is probably related to diet, characterized by low fat and animal protein intake, high ingestion of grains and tubercular roots, high salt intake, and low intake of fresh fruits and fresh vegetables. Some foods such as fava beans and Japanese fish are suspected of yielding gastric carcinogens after nitrosation. Populations at high risk in which the intestinal type predominates have a high prevalence of atrophic gastritis and intestinal metaplasia. Some of these precursor lesions reach the precancerous stage of dysplasia. The management of these lesions needs further clinical research. Some gastrectomy techniques facilitate the reflux of bile acids into the stomach where they may react with nitrite to produce mutagens and possibly carcinogens. The risk of "stump-carcinoma" increases with time after gastrectomy. Billroth II operations should be replaced with techniques that minimize duodenal reflux.
 ...
PMID:Clinical implications of recent developments in gastric cancer pathology and epidemiology. 397 43


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>