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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We assessed the results of endoscopic resection (ER) of early gastric cancer using electrocoagulation with high frequency current. Resection was performed utilizing endoscopic double-snare polypectomy (EDSP) and electrocoagulation. The initial endoscopic total resection rate was 65.0% (119/183 lesions). There were 32 lesions in which no residual cancer was present at follow-up biopsy or surgery, and when these were included the endoscopic resection cure rate was 82.5%. Extensive tissue necrosis and degeneration occurred in the resected stump as a result of using electrocoagulation. Since an increase in suitable patients and an expansion of the indications for endoscopic resection are anticipated in the future, careful clinical evaluation of endoscopic resection based on the results of pathological assessment of the resected tissue is needed.
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PMID:[Endoscopic treatment of early gastric cancer]. 150 80

A case of flat-elevated type (IIa) early gastric cancer completely eradicated with contact Nd-YAG laser is reported. The patient was diagnosed as having early gastric cancer (type IIa) by endoscopic examination. Biopsy revealed a well-differentiated adenocarcinoma. He declined surgery and subsequently received 4 sessions of contact Nd-YAG laser treatment with a total output of 1245 watt-sec. An ulceration was created by the end of the third session of laser treatment. He finally agreed to surgery and a subtotal gastrectomy was performed after completion of four sessions of therapy. Meticulous histologic examination of the resected specimens revealed no residual cancer cells. This is the first report of endoscopic curative treatment of gastric cancer by contact Nd-YAG laser in Taiwan. This technique may provide an alternative for patients with early gastric cancer, who have a high surgical risk.
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PMID:Non-surgical radical treatment of early gastric cancer by endoscopic contact Nd-YAG laser: report of a case. 197 50

A 64-year-old woman with Borrmann type 4 gastric cancer was treated by intraaortic (celiac artery) one-shot infusion chemotherapy with adriamycin (ADM) and mitomycin C (MMC). One month after the first administration of 30 mg ADM and 20 mg MMC, the second administration of 50 mg ADM and 20 mg MMC was done. The third administration of 50 mg ADM and 20 mg MMC was performed one month after the second administration. Clinical symptoms of back pain, lumbago and anorexia had almost disappeared soon after the third administration. Although the findings of the X-ray examination of stomach, gastroscopy and celiac angiography showed marked improvement, total gastrectomy with lymphadenectomy was performed 2 months after the third administration because residual cancer cell nests were highly suspect. Histological examination of the resected stomach and lymphnodes revealed no cancer cells. The patient has been in good health without any recurrent signs for 16 months after operation.
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PMID:[A case of Borrmann type 4 gastric carcinoma which disappeared by intraaortic infusion chemotherapy with ADM and MMC]. 211 4

A 78-year-old female was diagnosed as having an early gastric cancer of II a (+II c) type with probable sm invasion by gastroscopic examination. Endoscopic polypectomy was carried out due to advanced age, severe ischemic heart disease, and refusal of surgical treatment. Most of the cancerous tissue were removed endoscopically, but biopsy specimens after polypectomy showed some tumor cells leaving at the excisional site. She was treated with local injection of OK-432 endoscopically, PSK orally, Tegafur rectally, and Lentinan intravenously. After about 7 months' treatments, biopsy specimens revealed no residual cancer cells. The total doses administered up to cure for cancer were 70 KE of OK-432, 141 g of PSK, 99 g of Tegafur, and 45 mg of Lentinan. The combination therapy with massive removal of cancer tissue by endoscopy, local injection of anti-cancer agent to residual cancerous lesion and systemic immunochemotherapy will be available and recommendable for poor risk patients with early gastric cancer.
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PMID:[A case of early gastric cancer disappeared by endoscopic polypectomy and local injection of anti-cancer agent associated with systemic immunochemotherapy]. 226 22

Gastroscopic mucosal biopsies and carbon ink injection marking were performed in 31 patients with gastric cancer before operation. The resection line of gastric wall was determined during operation according to the marked points. The method, dose, site, and opportunity of ink injection were studied. The results were: 1. None of these 31 patients had positive biopsies from cancer free areas. None of the resected specimens showed deep cancer infiltration beyond the site of carbon ink injection. This method is significant in recognizing the extent of intramucosal cancer infiltration; 2. None of the 31 patients marked by ink injection had residual cancer on the resected line whereas 8-10% of those unmarked had a positive margin. This result indicates that this method is significant in avoiding residual cancer on the resection line; and 3. Before surgery, the home-made carbon ink was satisfactory. The optimum dose for an ideal ink point was 0.05-0.1 ml/point which would give a marking of 0.5-1.5 cm in diameter on the serosa. The ink point was clearly shown on the anterior wall but less satisfactorily on the lesser curvature of the stomach. Injection performed as early as the fifth week before operation was valid.
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PMID:[Gastroscopic mucosal biopsy and carbon ink injection marking for determination of resection line on the gastric wall in stomach cancer]. 280 43

During the period from June 1973 to December 1978, 338 patients with advanced gastric cancer were treated in our hospital. By retrospective grouping, 142 out of 265 patients with tumor resected received postoperative adjuvant chemotherapy (MMC + 5FU + Ara-C), 123 operated alone were taken for comparison. These two groups were similar in: age, sex, location of tumor, mode of resection, histological type, clinical stage and follow-up rate. The results indicated that the 1, 3 and 5 year survival rates of the combined group were much higher than those of the operation only group. Further analysis showed that the supplementary chemotherapy was particularly valid in stages III and IV. In stage III patients, the 5 year survival rate was increased by 27.8%. In stage IV patients, the 3 and 5 year survival rates of the combined group were 16.3% and 9.8% but none survived over 3 years in the operation only group. The authors believe that postoperative adjuvant chemotherapy plays an important role in controlling the micrometastatic and residual cancer foci.
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PMID:[Long-term results of an operation alone and postoperative adjuvant chemotherapy in advanced gastric cancer--report of 265 patients]. 283 38

The indication for EDSP was studied in 75 patients with early gastric cancer diagnosed endoscopically which had been obtained over a period of 11 years (1979 to 1985) at the Cancer Institute Hospital, Tokyo and the following results were obtained. EDSP consists of two procedures using double channel fiberscope; a sessile or depressed lesion pulled upward by one snare cautery (standard EDSP) is transformed into a subpedunculated one, which allows another snare cautery of pseudostalk, and it is excised by using coagulation current. EDSP was performed in 53 cases of IIa type and 22 cases of IIc type. Excision by one snare cautery was possible in 90.9% (40/44) of IIa lesion measuring less than 2 cm and in 100% (14/14) of IIc lesion measuring less than 1 cm, the total being 85.3% (64/75). There was no residual cancer in 41 cases of IIa lesion (93.2%) and 17 cases (85.0%) of IIc lesion with two recurrent cancers confirmed by follow-up endoscopy. Residual cancer was found in 6 cases (9.1%) which were operated on. The results mentioned above show the usefulness of EDSP and selection of case without lymph node metastasis permitting complete excision by one snare cautery is of much importance. EDSP is indicated for IIa lesion of differentiated type measuring less than 2 cm, IIc lesion of differentiated type without ulceration measuring less than 1 cm and IIc lesion of undifferentiated type without ulceration measuring less than 0.5 cm that is not located in the fundic gland area.
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PMID:[Treatment of early gastric cancer by endoscopic double snare polypectomy (EDSP)]. 378 48

It is well generally accepted that several tumor markers may be useful for determination of staging, metastatic patterns, devices of the malignancy and prediction of recurrence in postoperative follow-up. Our analysis of tumor markers in gastrointestinal cancer indicated that the patients who had a high level of AFP in the serum of gastric cancer patients showed a correlation between preoperative AFP level and liver metastasis. In patients with carcinomatous peritonitis positive rate of CA125 level in serum was 42.9% and, more importantly, the elevation of CA125 level after surgery was observed in 72.2% of patients complicated peritoneal dissemination before clinical evidence. On the other hand, the change of tumor marker levels in serum after surgery were plotted on a semi-logarithmic scale and we monitored tumor marker changes until the level decrease to the normal range or when recurrence was detected on imaging diagnosis. All patients showing high levels of CEA had surgical resection for gastrointestinal cancers. In the group of 25 patients who had no recurrence within 1 year or more, CEA levels decreased exponentially until these reached the normal range. The half life period of CEA was 4 to 5 days. However, CEA levels in 13 of 19 patients who recurred showed a dissociation from the theoretical line of half life period before the level decreased to normal range. We interpreted that this dissociation was caused by the growth of residual cancer cells. In other word, if dissociation point from exponential decrease line of CEA were pointed after the surgery, we can predict a possibility of recurrence in earlier period after surgery.
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PMID:[Prediction of recurrence of gastrointestinal cancer from standpoint of biological malignancies--tumor marker doubling time and its a half life period line]. 769 53

Following refinement of endoscopic diagnosis of gastric cancer, the concept of 'early gastric carcinoma' and its endoscopic features have become established. After the wide acceptance of the techniques of endoscopic mucosal resection (EMR), laser therapy and accurate endoscopic-endosonographic assessment of the depth of invasion, curative endoscopic treatment of intramucosal gastric carcinoma has become established. On the basis of the analysis of lymphatic metastasis, the indications for endoscopic treatment of gastric carcinoma have been defined as (1) well-differentiated, intramucosal adenocarcinoma of a superficial elevated lesion (diameter < 2 cm), and (2) well-differentiated, intramucosal adenocarcinoma of a superficial depressed lesion (diameter < 1 cm) having no ulcer or scar inside. The preferred procedure of endoscopic treatment is EMR with careful histological examination of the resected specimen. It is supplemented by repeat EMR, laser therapy, or surgical gastrectomy in case of incomplete resection. For detection of residual cancer and recurrence, periodic endoscopic follow-up is necessary. Early gastric carcinoma is endoscopically curable.
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PMID:Gastric carcinoma, an endoscopically curable disease. 791 89

A total of 211 patients with gastric cancer in the upper third of the stomach were clinicopathologically evaluated. Of the 211 patients, 82 had esophageal infiltration and 129 did not. These two groups were compared. The study on patients who had undergone resection and radioisotope (99mTc-phytate) uptake testing revealed that it was important to dissect the lymph nodes (predominantly nodes 7, 9, 11, and 16) during surgery in the patients with gastric cancer plus esophageal infiltration. When cancer infiltration of the esophagus exceeds 1 cm, the preferred surgical procedure is lower esophagectomy and total gastrectomy with abdominal and intrathoracic lymphadenectomy via the left thoracoabdominal approach. When residual cancer is suggested in the more proximal esophageal stump due to intramural metastasis from vascular invasion, rapid pathologic diagnosis should be made by frozen sections during surgery and then subtotal esophagectomy by blunt removal of the esophagus proximally from the aortic arch using a left thoracotomy considered.
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PMID:Clinicopathologic features of gastric cancer infiltrating the lower esophagus. 809 86


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