Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

CEA producing cell lines were established from human gastric cancer (HGC-Y1), pancreatic cancer (HPC-Y9) and lung cancer (HLC-Y1). The culture medium was used RPMI-1640 supplemented with 10% fetal bovine serum. The secretion of carcinoembryonic antigen (CEA) into the spent medium from these cultured cell lines was modified by several factors, such as theophylline, cyclic AMP (cAMP), dibutyryl cyclic AMP (dbcAMP), Bromodeoxyuridine (BrdUrd), dimethyl sulfoxide (DMSO), Prostaglandin E2 (PGE2) and human interferon (INF). CEA secretion was enhanced by theophylline, cAMP, PGE2 and INF. Theophylline had an optimal dose to maximally enhance CEA secretion. cAMP and INF apparently enhanced CEA secretion dose dependently. PGE2 appeared to enhance CEA secretion, although cell growth was markedly suppressed dose dependently, dbcAMP, DMSO and BrdUrd did not affect CEA secretion. Here, the kinetics of CEA secretion was discussed.
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PMID:Factors affecting the CEA secretion of human adenocarcinoma cell lines into the spent medium. 631 8

To clarify the significance of immunoreactive carcinoembryonic antigen in gastric juice (gastric CEA) from gastric cancer patients, we studied the gastric CEA in comparison with cancer progress, histologic types of tumors, staining for CEA and extent of intestinal metaplasia. The gastric CEA levels from patients with other gastric diseases, i.e., gastric ulcer, duodenal ulcer and chronic gastritis were also investigated. The mean gastric CEA level from gastric cancer patients was significantly higher than from gastric or duodenal ulcer patients, but there was no significant difference between levels in patients with gastric cancer and in those with chronic gastritis. The gastric CEA levels from cancer patients increased with progression of the cancer. The differentiated carcinomas showed significantly higher gastric CEA levels than the poorly differentiated carcinomas. Positive CEA tumors showed significantly higher gastric CEA levels than did the negative CEA tumors. The tumors with diffuse intestinal metaplasia revealed high gastric CEA levels. Determination of gastric CEA levels is considered to be useful for screening of gastric cancer.
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PMID:Immunoreactive carcinoembryonic antigen in gastric juice in patients with gastric cancer. 635 92

Plasma carcinoembryonic antigen (CEA) was examined in 122 cases of gastric cancer and immunohistochemical localization was also studied in 102 resected specimens. A comparative study between tissue CEA and plasma CEA was carried out. The results were as follows. Plasma CEA were positive (over 2.5 ng/ml) in 46 cases (37%). The positive rate was parallel with the size of cancer (p less than 0.05) and was higher in well-differentiated cancer. As to tissue CEA, 87 specimens (85%) showed the varying degree (+/- +) of positive reaction. CEA was localized in luminal border, cytoplasma and grandular lumen in well differentiated cancer, and only in cytoplasma in poorly differentiated cancer. The positive rate of plasma CEA was parallel with the degree of positive reaction in tissue. No significant histological difference was observed between strong positive reaction to tissue CEA and positive plasma CEA. In the cases with moderate positive reaction to tissue CEA, however, the positivity of plasma CEA was significantly higher in the cases with alpha or beta INF pattern and/or intermed stromal reaction. (p less than 0.05).
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PMID:[Immunohistochemical localization of carcinoembryonic antigen (CEA) in gastric cancer--a comparative study between tissue CEA and plasma CEA]. 637 86

Gastric cancer specimens obtained from 162 patients who had undergone radical surgery with the routine postoperative administration of both mitomycin C and 5-fluorouracil were stained for carcinoembryonic antigen (CEA) by the unlabeled antibody enzyme technique. The CEA (-/+) group (92 cases) consisting of the negative and weakly positive staining cases had a significantly better survival rate over a period of 5 years than the CEA (++) group (70 cases) which comprised only strongly positive cases. The CEA (-/+) group with differentiated adenocarcinoma had the best prognosis and the 5-year survival rate was significantly higher than those of the other three groups. Among stage II and III carcinomas, the postoperative survival rate was significantly better in the CEA (-/+) group than in the CEA (++) group. Among the patients with lymph node metastasis, the postoperative survival rate was low, especially in the CEA (++) group. The present data suggest that staining for CEA in tissue sections of stomach carcinoma may be helpful in differentiating among tumors that appear similar by conventional histological methods, thus providing a new means for obtaining more precise prognostic information.
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PMID:Correlation between carcinoembryonic antigen in gastric cancer tissue and survival of patients with gastric cancer. 637 75

Serum tissue polypeptide antigen (TPA) levels were measured in 33 patients with esophageal cancer, 39 with stomach cancer and 50 with colon cancer. At the same time five glycoproteins, namely immunosuppressive acidic glycoprotein (IAP), alpha 1-antichymotripsin (alpha 1-ACT), acid soluble glycoproteins (ASP), sialic acid and carcinoembryonic antigen (CEA), were measured for comparison. The mean TPA values were 59.0 +/- 15.4 U/l in 61 normal subjects, 103.6 +/- 104.2 U/l (positive rate, 24.2%) in esophageal cancer patients, 111.9 +/- 49.8 U/l (71.8%) in stomach cancer patients and 124.8 +/- 195.5 U/l (40%) in colon cancer patients. The serum TPA levels in patients with stomach cancer rose with an increased number of involved lymph nodes and with a higher degree of infiltrative growth and increased with the advancement of tumor growth postoperatively. Serum TPA levels correlated well with those of alpha 1-ACT, IAP and ASP in stomach cancer patients and with those of CEA, ASP and sialic acid in colon cancer, but not in esophageal cancer patients. It is suggested that the serum TPA might represent one of the reactant proteins and/or tumor-associated antigens that appear to be dependent upon the cancer status.
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PMID:[Clinical evaluation of tissue polypeptide antigen in patients with esophageal, stomach and colon cancer]. 648 66

A radioimmunoassay of the carcinoembryonic antigen, gastrin and immunoglobulin E was performed in the blood serum of more than 300 esophageal and gastric cancer patients. It has been noted that the CEA study makes it possible to determine the severity of disease and may serve as a yard-stick of radical therapy. Hypogastrinemia develops in 82-84% of patients with tumors of these sites. The gastrin level after therapy depends on the nature and type of antitumor therapy. An increase in the IgE level is a risk factor which makes it possible to identify patients with an "unfavorable" or complicated course of disease and to determine, to some extent, prognosis, to control therapeutic measures in combined treatment. The use of the radioimmunoassay for CEA, gastrin and IgE in the combined study of esophageal and gastric cancer patients allows one to evaluate the patients's status before treatment and to determine their response to tumor therapy.
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PMID:[Radioimmunoassay of carcinoembryonic antigen, gastrin and immunoglobulin E in evaluating different methods of treatment of patients with esophageal and stomach cancer]. 650 53

In this study, the clinical significance of the tumor markers, tissue polypeptide antigen (TPA) and lipid-bound sialic acid (LBSA) in conjunction with carcinoembryonic antigen CEA, was tested in 52 gastric cancer patients. The incidence of elevated serum levels of these 3 markers was as follows: 63% (33/52) for TPA; 40% (21/52) for LBSA; 21% (11/52) for CEA. In a combination assay using all three tumor markers, 37 out of 52 gastric cancer patients (71%) showed a positive combination assay, while 5 out of 20 normal subjects (25%) showed a positive combination assay. In a discriminant analysis of the resulting data, 18 out of 52 gastric cancer patients (35%) were classified correctly based on an analysis of CEA alone. Furthermore, 25 out of 52 gastric cancer patients (48%) and all 20 normal subjects (100%) were classified correctly based on an analysis of all three variables. Our data suggest that TPA and LBSA are more sensitive than CEA as markers of gastric cancer, and that the simultaneous measurement of TPA and LBSA in conjunction with CEA is more useful in cancer detection than the measurement of CEA alone.
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PMID:Detection of gastric cancer by a combination of tissue polypeptide antigen (TPA), lipid-bound sialic acid (LBSA) and carcinoembryonic antigen (CEA). 651 14

It is known that interstitial collagens are initially synthesized as precursors (procollagen), which possess extra peptide segments at both ends of the molecules. The authors attempted to detect the aminoterminal peptide of type III procollagen (type III-N-peptide) and also to measure the carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) together in sera of patients with gastric cancer. The results showed that: (1) mean serum levels and positive ratios of the type III-N-peptide increased as the clinical stage of the patients with gastric cancer advanced; (2) serum levels of the type III-N-peptide were not correlated either with those of CEA or CA 19-9; (3) positive ratios of type III-N-peptide, CEA and CA 19-9 were 51.7%, 44.8% and 48.3%, respectively: (4) positive ratio in combination of the type III-N-peptide with CEA was 69.3% and that in combination of the type III-N-peptide with CEA and CA 19-9 was 72.4%. These results suggest that type III-N-peptide is available for diagnosis of gastric cancer and, that the combination assay of type III-N-peptide with CEA and CA 19-9 is more effective than a single assay for diagnosis.
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PMID:[Diagnostic values of type III Procollagen N-terminal peptide and combination assay of type III procollagen N-terminal peptide with CEA and CA 19-9 in gastric cancer]. 658 22

In order to ascertain the role of gastric carcinoembryonic antigen (CEA) determination in detecting patients with a risk for gastric cancer, 69 subjects were studied; 23 were referred for endoscopy because of dyspepsia but without obvious macroscopic lesions, 27 with duodenal ulcer, 11 with benign gastric ulcer, 8 with gastric cancer. The following results were obtained by subdividing the material according to the histologic interpretation of the results of gastric mucosal biopsies: (1) in the presence of minor histologic abnormalities of the gastric mucosa, CEA in gastric juice was under 100 ng/ml in all but five cases; and (2) in moderate or severe chronic atrophic gastritis (associated or otherwise with intestinal metaplasia or dysplasia), and in gastric cancer, gastric CEA ranged between 224 and 3120 ng/ml in all but two cases. Although not diagnostic for gastric cancer, gastric CEA is a promising test in detecting patients at risk, including those with dysplasia of the gastric mucosa.
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PMID:Carcinoembryonic antigen in gastric juice collected during endoscopy. Value in detecting high-risk patients and gastric cancer. 664 May 4

A quantitative study of carcinoembryonic antigen (CEA) was made in nine human gastric cancer cell lines. Six of them were found to produce CEA in vitro. The production of CEA in the three cell lines derived from well differentiated tubular adenocarcinomas began at the mid-exponential phase of cell growth and reached its peak at the late stationary phase, the amount of CEA per 10(5) cells and the frequency of CEA-positive cells on immunostaining increased with culture time. In contrast, CEA in the three cell lines derived from poorly differentiated adenocarcinomas including a signet-ring cell carcinoma was produced immediately after plating and the amount of the antigen per 10(5) cells and the frequency of CEA-positive cells were almost constant throughout the cell growth phases. Serum CEA content in nude mice was low or not detectable in the case of subcutaneous heterotransplantation of gastric cancer cells, irrespective of CEA productivity of the cell lines in vitro. Intraperitoneal inoculation, however, led to high CEA levels in sera of nude mice bearing human gastric cancers. No significant difference was found between the two kinds of inoculation in terms of the total tumor weight and the frequency of CEA-positive cells in tumor tissues. One reason for the above findings may be that the transport of CEA in the subcutaneous tumors to the systemic blood flow is hindered.
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PMID:Carcinoembryonic antigen production in human gastric cancer cell lines in vitro and in nude mice. 664 41


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