Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Regan isoenzyme, variant alkaline phosphatase, and alpha-fetoprotein were found in the serum of a patient with gastric cancer. The histology of the tumor was tubular adenocarcinoma. There were metastases in the retroperitoneal lymph nodes, but not in the liver. The liver was normal microscopically, with no evidence of bile duct obstruction. alpha-Fetoprotein in the tumor tissue was detected by immunoprecipitation reaction in agar. Regan isoenzyme and variant alkaline phosphatase were also detected in the tumor tissue and total alkaline phosphatase activity of the tissue was very high. These findings suggested their tumor origin.
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PMID:Occurrence of alpha-fetoprotein, Regan isoenzyme, and variant alkaline phosphatase in the serum of a patient with gastric cancer. 5 76

In the years from 1964 to 1973, 672 patients with gastric cancer were treated in the Surgical Department of Medical Academy Dresden. Tumors were located in the gastric antrum in 28.9%, in the cardia-fundus region in 28,1%, in the corpus ventriculi in 18.3%, and had involved the stomach totally in 18.6%. A resection was performed in 268 cases or 50.0%. Postoperative fatality rate was 20.1% but amounted to 30% in resection of the proximal part of the stomach and in total gastrectomy. The 5-year relative survival rate was 35.0% in distal partial gastrectomy, 10.4% in proximal partial gastrectomy, 8.2% in total gastrectomy, and 20.1% for all resections. Prognosis depends on local extension and on lymph node metastasis. Results are compared with data from the literature.
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PMID:[Surgical treatment of gastric cancer-personal results (author's transl)]. 6 44

Human gastric cancer-associated antigens were solubilized from fresh ascites and surgical specimens by 3M KCl extraction. The antigenicity of these extracts was measured by leucocyte migration inhibition assay with an improved modification devised in this laboratory. Antigens extracted mutually reacted with autologous and allogeneic leucocytes taken from cancer patients. The out of 11 (27%) patients and 7 out of 28 (25%) patients with various cancers showed positive migration index values against 13 ascites tumor cell antigens in the autologous and allogeneic reaction systems, respectively. Reactions were positive in 4 out of 10 patients with gastric cancer against autologous antigens, and in 10 out of 26 (38%) of the patients against allogeneic tumor antigens. On the other hand, one patient with gastric cancer reacted well with various sources of antigens extracted from allogeneic cells of gastric cancer, while the other patient with gastric cancer did not react with any of five gastric cancer antigens tested so far. These findings suggested that the cell-mediated immune response of patients with gastric cancer against autologous and allogeneic tumor antigens extracted was detectable in the test system. It is considered at present that the eM KCl antigen may be relate to human leucocyte antigen, and some common antigenic reactants capable of reacting with several gastric cancer may be involved in this reaction.
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PMID:Inhibition of leucocyte migration by potassium chloride extracts of human tumor cells in ascites and from tissues. 7 89

Although several investigators have reported serum alpha-fetoprotein positive gastric cancer with or without metastasis to the liver, its site of production is still unclear. We studied on the site of alpha-fetoprotein synthesis in our cases which showed remarkably high level of serum alpha-fetoprotein, and clarified the presence of alpha-fetoprotein producing gastric cancer by means of direct immunofluorescent technique. However, we also knew the hepatocytes adjacent ot the metastatic lesions could also synthesize alpha-fetoprotein, although these hepatocytes were not known whether under regeneration or degeneration. Through this study, the other carcinofetal proteins such as carcino-placental alkaline phosphatase and CEA were examined using the sera or tumor tissues. Our results will support the idea that cancer is the disease of cell differentiation.
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PMID:Carcino-fetal proteins and gastric cancer: the site of alpha-fetoprotein synthesis in gastric cancer. 7 49

Utilizing the lipid-adsorbing ability of lymphatic capillaries, anticancer agents were given in the form of fat emulsion in order to deliver them to regional lymph nodes. The emulsion, in which the drug solution is contained as the innermost phase, yielded high drug concentration in the lymphatic system. Intratumoral injection of emulsified anticancer agent resulted in significantly prolonged retension of the drug within the tumor tissue. Therapeutic experiments of the emulsion also disclosed remarkable tumor reduction and cure rate as compared with aqueous solution of drugs. Oral administration of emulsified 5-Fluorouracil (5-FU) was also attempted for stomach cancer. With 5-FU, the maximum concentration of drug in thoracic lymph and stomach was greater when administered as an emulsion than as an aqueous solution, and a high concentration persisted longer. As a clinical trial of the emulsion method, eight patients with inoperable malignant growth were injected locally with emulsified anticancer agents and 121 patients were given 5-FU emulsion orally. From the clinical and histological findings, it was thought that the emulsion enhanced the chemotherapeutic effect of the anticancer agent on lymph node metastasis.
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PMID:Enhancement of the cancer chemotherapeutic effect by anticancer agents in the form of fat emulsion. 7 67

Hypertonic extracts from human fetuses (10--22 wk of gestation) were used to test the sensitizaton of leukocytes from cancer patients against fetal antigens in a direct, microcapillary tube assay system. Leukocytes were simultaneously exposed to a panel of allogeneic tumor extracts and a panel of fetal extracts. Leukocytes from 24 gastric cancer patients, 43 colorectal cancer patients, and 13 lung cancer patients were assayed with extracts obtained from gastric, colorectal, and oat cell carcinomas, respectively, and these extracts were also used with leukocytes from 41 patients bearing tumors of various other organs. Significant migration inhibition by tumor extracts was observed in 81.6% of the tests with gastric cancer, 67.4% of the tests with colorectal cancer, 69.0% of the tests with lung cancer, and 51.2% of the tests with other types of cancer. With fetal extracts, significant migration inhibition occurred in 58.3, 58.7, 59.6, and 54.9% of the tests, respectively. Reactivity against fetal extracts did not depend on the gestation age of the fetuses used for extraction. The conclusion was reached that the leukocytes of most of the cancer patients were sensitized against substances contained in fetal extracts irrespective of the type of tumor of the leukocyte donor. The cross-reactivity pattern suggested that 3-M KCl extracts of whole human fetuses contained a complex mixture of specificities related to the various fetal organs and tissues, which may have represented counterparts to most of the tumor-associated specificities.
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PMID:Sensitization of leukocytes of cancer patients against fetal antigens: leukocyte migration studies. 8 34

Vitamin A level and the cytosol-binding proteins specific for vitamin A ere studied in human tumor and its surrounding tissue. The tissues examined were 10 hepatocellular carcinomas which were surgically removed, 4 other malignant tumors (2 metastatic liver cancer and one each of gastric cancer and glioma), and 3 human fetal livers. Compared with surrounding tissues, considerable decrease of vitamin A content was observed in the hepatocellular carcinoma suggesting local deficient state of the vitamin. In addition to cellular retinol-binding protein (CRBP) and retinoic acid-binding protein (CRABP), a new molecular species having affinity for both retinol and retinoic acid was detected in the cytosols obtained from hepatocellular carcinoma as well as glioma by means of gel filtration on Sephadex G-75. With regard to ligand specificity, the protein was found to be similar to cellular retinol-binding protein, F-type or CRBP(F) which was originally recognized in the fish eye cytosol. Since the protein was also demonstrated in human fetal liver, CRBP(F) is considered to be an oncofetal protein in nature. The present study further revealed that CRBP(F) was detected in 80% of hepatocellular carcinoma (whereas plasma alpha-fetoprotein was significantly elevated only in 50%), and hepatocellular carcinoma contained CRBP(F) in a larger amount than CRABP.
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PMID:Demonstration of a novel cellular retinol-binding protein, F-type, in hepatocellular carcinoma. 8 58

Specificity of micro-leucocyte adherence inhibition (LAI) test was studied in patients with gastric cancer. Because of the presence of nonspecific reactions, specificity appeared obscure unless interaction analysis was applied to the results of LAI tests. Application of interaction analysis revealed that only leucocytes from patients with gastric cancer showed specificity to gastric cancer antigen. Further technical improvement is required to eliminate nonspecific reactions which seem to be due to either leucocytes or tumor antigens.
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PMID:Specificity of micro-leucocyte adherence inhibition test in patients with gastric cancer. 9 33

Of 102 cases of gastric carcinoma operated on, the tumor could be resected in only 53 patients. Over 60% of all cases had prolonged medical treatment before the diagnosis of gastric cancer was made. Most of the lesions were huge and locally advanced. Twenty nine operations could be considered as radical procedures, but, only fifteen of them filled the requirements of a curative radical operation (28,3%). There was no uniformity in the way that the surgical treatment was performed and too many Billroth I operations were done, (28%). This mainly because a preoperative surgical plan was not on hand. The overall surgical mortality was 14 per cent for all the cases explored, but increased to 22,5 per cent for the cases in which the tumor was resected. There was no case in which the tumor was limited to the mucosa and in the four cases classified as T1 the lesion infiltrated the muscular layer. The radical gastrectomy showed its benefits, only in those cases with limited penetration and negative nodes. This was sustained by the fact that the only survivals over ten years were four cases in the category of T2N2M0 and all of them were submitted to a radical gastrectomy. But, in advanced cases with large lesions and positive nodes the morbidity and mortality were considerable higher and survival was not even above two years. An effort in every way must be done to try to operate lesions much less advanced, but at the same time it is necessary the practice of radical surgical curate procedures in such cases.
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PMID:[Gastric cancer. A review of the subject]. 12 90

A cell line (HGC-27) was established by culture of the metastatic lymph node from a gastric cancer patient diagnosed histologically as undifferentiated carcinoma. HGC-27 cells were polygonal or short spindle-shaped and adhered to glass surfaces as a monolayer. The cells were probably derived from gastric cancer cells, as their origin from mesenchymal tissues can be excluded morphologically and enzyme-histochemically. Enzyme activities were generally negative or low, except for adenosine triphosphatase, lactic dehydrogenase and leucine aminopeptidase. These scanty findings might reflect the undifferentiated character of the original tumor cells. The cloning efficiency was 5.3% in liquid medium and 1.0% in soft agar. The doubling time was about 17 hr. Chromosomal analysis revealed a mode of 109 and 110 chromosomes.
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PMID:Human cell line (HGC-27) derived from the metastatic lymph node of gastric cancer. 13 73


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