Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have measured serum TNF-alpha levels in 220 gastric cancer patients, 9 patients with gastric polyps or ulcers, 9 hepatitis B carriers and 85 normal controls. The results showed that no positive TNF-alpha value (> 10 pg/ml) was detected in Hepatitis B carriers and benign gastric lesions' patients and normal controls. In the cancer group, 17 out of 220 patients (7.7%) had positive-TNF-alpha values. The proportion of TNF-alpha positive was 6.8% in stage I disease, 6.5% in stage II disease, 3.7% stage III, and 12.9% stage IV. No clinicopathologic factors were related to positive TNF-alpha value. TNF-alpha value was not an independent prognostic indicator The role of TNF-alpha in gastric cancer remains obscures.
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PMID:Serum tumor necrosis factor in patients with gastric cancer. 967 76

We present herein the case of a 68-year-old man in whom metachronous liver metastasis from an alpha-fetoprotein (AFP)-producing gastric cancer was successfully treated. The patient initially underwent a distal gastrectomy for an AFP-producing gastric cancer on January 30, 1997, following which the serum AFP level which had been 228 ng/ml prior to surgery decreased to 30 ng/ml. However, 7 months after surgery, follow-up examination revealed an abnormal elevation of the serum AFP level up to 301 ng/ml, and a liver tumor was subsequently detected at segment 8 (S8) by abdominal ultra-sonography. There was no evidence of hepatitis B or C virus infections. After various investigations, he was diagnosed to have liver metastases in S6 and S8, from the AFP-producing gastric cancer, and a partial hepatectomy of S6 and S8 was performed. His postoperative course was uneventful and he was discharged on postoperative day 26. Thereafter, his serum AFP levels decreased and have remained within normal limits for 12 months since his operation. To the best of our knowledge, this is the first case of successful resection of metachronous liver metastasis from an AFP-producing gastric cancer.
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PMID:Successful resection of metachronous liver metastasis from alpha-fetoprotein-producing gastric cancer: report of a case. 1055 33

PURPOSE: This article summarizes demographic characteristics of Korean Americans and reviews health issues in this population. METHODS: The authors reviewed census data, monographs, books and medical literature published in the English language. FINDINGS: Korean Americans are one of the fastest growing Asian American groups in the United States. They are a heterogeneous population, differing in their cultural, religious and linguistic norms. Early data suggest that Korean Americans have lower overall mortality rates than the general United States population. However, they have special problems with respect to stomach cancer, liver cancer, hepatitis, mental health, access to health care and other issues. CONCLUSIONS: The health issues of Korean Americans have been generally overlooked until the present time. Examination of these emerging problems should contribute to the future of American health. RELEVANCE TO ASIAN PACIFIC ISLANDER AMERICAN POPULATIONS: This paper is particularly relevant to Korean Americans. KEY WORDS: Korean Americans, health education, hepatitis B, stomach cancer and tuberculosis
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PMID:Health Issues in Korean Americans. 1156 50

New Zealand has a cancer profile similar to those of Western developed countries, with a high rate of melanoma, similar to Australia. Statistics separating the Maori from the non-Maori population, although open to difficulties in interpretation, show higher rates in Maori of liver, stomach, lung and cervix uterine cancer and lower rates of colorectal cancer and of melanoma. Screening and prevention programmes are limited by resource constraints; there is population screening for cervical cancer and breast cancer screening is being developed. Screening for hepatitis B and liver cancer is proposed, despite conflicting scientific opinions, while screening for colorectal cancer is not planned, despite randomized trial evidence of benefit. There is no clear national cancer control programme at present. Investigation of stomach cancer in Maori families had identified a new gene.
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PMID:Developing areas in cancer in New Zealand. 1195 77

We report on two female patients who presented with painful recurrent palpable purpura, ulcers and necroses on the extremities. The results of all examinations and laboratory tests considered together suggested a diagnosis of necrotizing leukocytoclastic vasculitis. Leukocytoclastic vasculitis is an inflammatory necrotizing condition of the superficial dermal vessels, presenting with variable clinical symptoms. In most cases it becomes manifest as palpable purpura, but hemorrhagic-necrotizing, bullous, nodular and urticarial presentations also occur. Common etiological factors include bacterial, viral or drug antigens, chronic infections (hepatitis B and C), non-Hodgkin lymphomas (monoclonal gammopathy, multiple myeloma), leukemia (hairy cell leukemia), and tumors (bronchial, breast, and gastric cancer) and also connective tissue disorders. In the course of the work-up, a plasmocytoma was discovered as the cause of the leukocytoclastic vasculitis, presenting in a similar way to livedo reticularis in one case and to pyoderma gangraenosum in the other.
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PMID:[Rare types of vasculitis as markers of plasmocytoma]. 1565 29

Many common cancers develop as a consequence of years of chronic inflammation. Increasing evidence indicates that the inflammation may result from persistent mucosal or epithelial cell colonization by microorganisms; including hepatitis B virus and hepatitis C virus, which can cause hepatocellular cancer; human papilloma virus subtypes, which cause cervical cancer, and the bacterium Helicobacter pylori, which can cause gastric cancer. At present, the cause of other chronic inflammatory conditions associated with increased cancer risk, such as ulcerative colitis, is obscure. Particular microbial characteristics as well as the type of the inflammatory response contribute to clinical outcomes via influence on epithelial cell and immune responses. Persistent inflammation leads to increased cellular turnover, especially in the epithelium, and provides selection pressure that result in the emergence of cells that are at high risk for malignant transformation. Cytokines, chemokines, free radicals, and growth factors modulate microbial populations that colonize the host. Thus, therapeutic opportunities exist to target the causative microbe, the consequent inflammatory mediator, or epithelial cell responses. Such measures could be of value to reduce cancer risk in inflammation-associated malignancies.
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PMID:Mechanisms of disease: Inflammation and the origins of cancer. 1626 81

Asian Americans are the nation's fastest growing racial group in terms of percentages, and they constitute a very heterogeneous population. The author reviewed the literature and proposed an agenda to reduce cancer health disparities based on this review and the accomplishments and aspirations of the National Cancer Institute-funded Asian American Network for Cancer Awareness, Research, and Training. The Asian American cancer burden is unique, unusual, and, to a certain extent, unnecessary. The Asian American cancer burden is unique, because Asians are the only racial/ethnic population to experience cancer as the leading cause of death. The unusual aspects of the cancer burden among Asian Americans include experiencing proportionally more cancers of infectious origin, such as human papillomavirus-induced cervical cancer, hepatitis B virus-induced liver cancer, and stomach cancer, than any other racial/ethnic population and, at the same time, experiencing an increasing numbers of cancers associated with "Westernization." To a certain extent, the cancer burden for Asian Americans is unnecessary if barriers to cancer screening, overcoming resistance to physician visits, and culturally competent interventions to reduce smoking, unhealthy diet, and increasing proper exercise can be instituted. Reducing cancer health disparities among Asian Americans will involve research into their unique, unusual, and unnecessary cancer burden.
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PMID:Cancer health disparities among Asian Americans: what we do and what we need to do. 1627 Mar 13

Chemoprevention, pharmacological intervention for disease prevention, aims to intervene in pathways that lead to clinical disease before the disease occurs. Cancer chemoprevention is a relatively new field, but for gastrointestinal cancers, clinical trials have highlighted the chemopreventive potential of several agents. For colorectal neoplasia, trials with aspirin and other non-steroidal anti-inflammatory drugs (NSAIDS) and calcium have demonstrated the most significant reductions of risk. In observational studies, NSAIDs also consistently appear to protect against oesophageal and gastric cancer. Calcium, and perhaps vitamin D, are also promising and have the advantage of being inexpensive, safe interventions. For the prevention of oesophageal cancer, antitumour-B and retinamide have provided hopeful results, although it is not clear that these findings can be extrapolated from the study populations in Asia to western countries. Evidence from China suggests that a combination of beta-carotene, alpha-tocopherol and selenium may protect against oesophageal cancer, but the relative importance of each agent is unclear, and, again, their effects in other populations has not yet been assessed. Mass immunization against hepatitis B seems to be the most effective means of reducing the incidence of hepatocellular cancer worldwide. In addition, treatment with interferon alpha in patients chronically infected with hepatitis C virus shows considerable promise, given the increasing prevalence of hepatitis C virus carriage in recent years. TJ-9, polyprenoic acid and anti-aflatoxin compounds are also possible avenues that deserve future research.
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PMID:Chemoprevention in gastrointestinal cancers: current status. 1661 Dec 3

A 57-year-old woman had previously undergone a living-donor liver transplantation (LDLT) for end-stage liver disease related to hepatitis B virus. The liver graft had been donated by her husband. Her postoperative course had been uneventful. In the course of postoperative surveillance, she was incidentally found to have gastric cancer by an endoscopic examination 2 years after the liver transplantation. A gastric resection was the treatment choice, and the results were successful. The tumor, which was moderately differentiated adenocarcinoma, was limited to the mucosal layer, with no metastasis. In addition, a Helicobacter pylori infection was observed. This is the first reported case of a gastric cancer after LDLT. We report this case because of its importance regarding the need to carry out close surveillance in transplant recipients who are treated with immunosuppressive drugs, in order to make a timely identification of the occurrence of common malignancies.
Gastric Cancer 2007
PMID:Experience of gastric cancer in a patient who had received a living-donor liver transplantation. 1792 98

A 70-year-old Japanese man underwent distal gastrectomy for gastric cancer. Preoperative computed tomography detected no tumor in the liver. Six months after the operation, ultrasound examination revealed a hyperechoic mass, measuring 3 cm in diameter, in the medial segment of the liver. Dynamic computed tomography of the liver also revealed that low-density area with mosaic enhancement in the dorsal portion of the medial segment. Assay for hepatitis B surface antigen was positive. Levels of carcinoembryonic antigen and alpha-fetoprotein were normal. Computed tomography during arterial portography revealed a perfusion defect in the area corresponding to the mass lesion. Although laparotomy was performed, no abnormality was found in the dorsal portion of the medial segment on inspection and palpation during surgery. We therefore performed incisional biopsy and frozen histologic examination, which revealed fatty deposition in the hepatic parenchyma and no evidence of malignancy. Finally, histologic examination made a diagnosis of macrovesicular steatosis surrounded by normal liver parenchyma.
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PMID:Focal fatty change in the medial segment of the liver occurring after gastrectomy: report of a case. 1881 65


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