Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

325 patients radically operated on for cancer of the breast, stomach, colon and rectum were given a rehabilitative treatment at a specialized out-patient department of the Dispensary. As a result, postoperative disorders were eliminated in 55% of breast cancer patients, 83.8% of cases of colonic and rectal cancer and 76.6% of gastric cancer patients. These indexes appeared to be significantly higher than those in controls who had not received rehabilitative treatment.
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PMID:[Rehabilitation treatment of cancer patients in ambulatory facilities]. 648 83

A phase II study of MCNU tablets in gastrointestinal cancer was carried out by the Hanshin MCNU cooperative study group involving 21 institutions. The selection of patients and evaluation of tumor response were based on the Criteria for the Evaluation of tumor Response by Chemotherapy in Solid Tumor Patients by Koyama and Saito. Of 67 patients who were entered into the study, 46 patients were evaluable, and comprised of 27 cases of gastric cancer, 13 of colorectal cancer, 2 hepatoma, and 4 patients suffering from other typas of gastrointestinal cancer. MCNU was administered orally at a dose of 50 mg/body/day for 4-6 days consecutive every 6-8 weeks. Only one partial response was obtained among the rectal cancer patients, with a response rate of 2.3% (1/43) in evaluable patients. Minor responses were obtained in 3 patients including 2 of gastric cancer with liver metastasis and 1 colon cancer with liver metastasis. Major side effects were marrow suppression and gastrointestinal symptoms. The former consisted of mainly leukopenia (15 patients, 30.0%), thrombocytopenia (20 patients, 40.0%), and oligochromaemia (10 patients, 20.0%). The latter consisted of mainly nausea and vomiting (5 patients, 10.0%).
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PMID:[A phase II study of ranomustine (MCNU) tablets in patients with gastrointestinal cancer--by cooperative study group]. 649

Clinical results of intraoperative radiotherapy (IOR) applied to carcinomas of the stomach, pancreas, and rectum were reported. In stomach cancer, the 5-year survival rates of patients treated by operation alone were 93.0% for stage I, 61.2% for stage II, 36.8% for stage III and 0% for stage IV. On the other hand, the 5-year survival rates of patients treated by IOR were 90.2% for stage I, 77.0% for stage II, 54.4% for stage III and 15.3% for stage IV. It has been demonstrated that IOR has definite effects on locally advanced gastric cancer. In pancreatic cancer, the median survival times for all patients treated by operation alone, IOR and IOR+ external beams were 3.5 months, 4.5 months and 8 months respectively. The median survival times of stage III patients treated by operation alone, IOR and IOR+ external beams were 5.5 months, 5.5 months and 12 months respectively. Our clinical results suggest that prolongation of life can be expected in patients who are treated by IOR followed by external beams and stage III is best indicated. In rectal cancer, it was found that stage IV as classified according to the rules for colorectal cancer studies in Japan is best indicated for IOR from the analysis of the survival figures. In stage IV patients, those who received operation alone could not survive more than 50 months while about 50% of those who were treated by IOR are alive 50 months after the treatment.
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PMID:[Radiotherapy for carcinoma of digestive organs]. 650 66

The geographical differences in mortality from cancer of seven sites of the digestive organs and consumption of foods in 46 of the prefectures, excluding Okinawa and their capital cities were statistically observed. The groups of foods statistically associated with cancer death are: pork, cooking oil and shochu (low class distilled spirits) for esophageal cancer; fresh fish, salted fish, vegetables and alcoholic beverages for stomach cancer; alcoholic beverages, salted or dried fish, vegetables, bread, milk, butter, margarine, ketchup, beer and fresh fish for colonic cancer; fresh fish, salted or dried fish, salt and popular grade sake for rectal cancer; pork, popular grade sake and green tea for cancer of the biliary passages; salted or dried fish, vegetables, alcoholic beverages, oil and fresh fish for pancreatic cancer; beef, poultry, eggs and vinegar for liver cancer. Further epidemiological analyses are required to find the biological causal relationships.
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PMID:[Geographical difference of mortality of digestive cancers and food consumption]. 651 19

According to age-standardized mortality rates (European standard population, Fig. 1) and mortality rates by birth cohort and age at death (Fig. 2-7) the trends of mortality of stomach and colorectal cancer (1966-1981/82) were analysed for men and women. In a further step it was examined how far these trends could be explained by the hypothesis "diet and cancer" (western diet). Under the postulation that the manifestation of western diet has reduced the risk of stomach cancer drastically, the risk of colorectal cancer has not increased to the same extent. Moreover, rectal cancer has shown only a slight increase and might even decrease in years to come. Having in mind the increasing risk, diet has no major impact so far. The differences in trends according to age groups and birth cohorts indicate the influence of other factors than diet. Furthermore, it is necessary to deal with colon and rectal cancer separately because of the differences in their trends.
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PMID:[Analysis of trends in stomach and intestinal cancer mortality in Austria]. 653 17

The relationships between areal differences in mortality from six digestive-tract cancers and consumption of selected foods in 46 of the 47 Japanese prefectures (Okinawa being excluded) were analyzed. Statistical analyses disclosed that the groups of foods positively associated with cancer death were as follows: for esophageal cancer, pork, oil, popular-grade sake, and green tea; for stomach cancer, fresh fish, salted or dried fish, salt, and special-grade sake; for colon cancer, bread, milk, butter, margarine, ketchup, beer, and salted or dried fish; for rectal cancer, fresh fish, salted or dried fish, salt, and popular-grade sake; for cancer of the biliary passages, pork, popular-grade sake, and green tea; and for pancreatic cancer, oil, mayonnaise, fresh fish, and salted or dried fish. These results are based on statistical analyses. Further epidemiological analyses are required to find a biological causal relationship.
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PMID:Statistical analyses on the pattern of food consumption and digestive-tract cancers in Japan. 654 78

The precision of CA 19-9 RIA kit was evaluated by recovery, reproducibility and dilution test with very satisfactory results. The CA 19-9 value in sera from 52 healthy individuals and from 224 patients with gastric intestinal cancer and other benign disease, showed an increased positive rate in several cases of gastric intestinal cancer. For example, the positive rate in pancreatic cancer, bile duct cancer, colo-rectal cancer, gastric cancer, esophagus cancer, primary biliary cirrhosis diabetes mellitus, liver cirrhosis and chronic hepatitis was 60%, 75%, 55.6%, 45.6%, 20%, 28.6%, 22.7%, 13.7% and 1.7% respectively. By contrast, values from patients with acute hepatitis, fulminant hepatitis, fatty liver, gastric duodenal ulcer, pancreatitis, and primary liver cancer were within the normal range. In this study, CA 19-9 RIA were found to be significant as an adjunct in the management of patients with gastrointestinal cancer, especially pancreatic cancer, and bile duct cancer.
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PMID:[Serum determination of CA 19-9 in patients with digestive cancers and its diagnostic evaluation]. 658 10

Responsiveness of experimental chemotherapy on human cancer xenografts in nude mice was directly compared with clinical response to the same chemotherapy in their donor patients. These xenografts were 1 line of rectal cancer (H-26), two lines of gastric cancer (H-08 and H-22), and 1 line of breast cancer (H-62). Experimental chemotherapies studied were single-drug FT-207 to four lines of xenografts and a combination of mitomycin C, 5-FU, and cytosine arabinoside (MFC) to a line of gastric cancer H-08. Single-drug treatment with FT-207 to H-26 resulted in remarkable retardation of the tumor growth. The comparative treatment with FT-207 suppository to the donor patient of H-26 showed appreciable response. All the other chemotherapies to three other lines (H-08, H-22, and H-62) induced no significant response, which was parallel to the corresponding clinical response in each donor patient. The sensitivity to chemotherapeutic drugs was thought to be still preserved in human cancer xenografts in nude mice.
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PMID:Relationship of chemotherapy on human cancer xenografts in nude mice to clinical response in donor patient. 677 50

Forty patients with gastric cancer and 30 patients with colon cancer were administered FT-207 prior to the operation. The relation between a total dose (4-88g) and tissue concentration of 5-FU was investigated and the following results were obtained. (5-FU concentration was measured with the method of Gas chromatography mas fragmentography) 1) The relation between total doses of FT-207 (x) and concentration of 5-FU in the tissue (y) was demonstrated by the formula: y = 0.00317x + 0.025 (gastric cancer) r = 0.519, p = 0.0001 y = 0.0019x + 0.043 (colon cancer) r = 0.641, p = 0.0001 2) In most of the patients with rectal cancer who received radiation therapy prior to the operation, 5-FU concentration in the tissue was extremely low. 3) 5-FU concentration showed no difference between the normal and metastatic lymph nodes, or among the lymph node groups. Administration methods (oral intake or suppository) had no influence on the concentration of 5-FU. 4) Among the organs, 5-FU concentration was higher in the following orders: liver, normal mucosa, lymph node, tumor, normal serosa. 5) In five autopsy cases, 5-FU concentration of the tissue show a great difference among them, and some cases showed 10 times as high concentration as others in the tissue of every organ.
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PMID:[Tissue concentration of 5-FU following pre-operative administration of FT-207]. 682 Sep 12

The relationship between colonic cancer and previous cholecystectomy was investigated in 90 Japanese patients treated surgically for colonic cancer during the period of 1971 to 1980. The patients were in an area where the inhabitants are considered to be at low risk for colonic cancer. The patients were matched for sex and age with other patients having gastric cancer or other digestive organ diseases. The results showed that previous cholecystectomy was prevalent, but the difference was not statistically significant, in the group of colonic cancer patients, compared with the groups of rectal cancer patients and matched controls. A positive association between the proximal colonic cancer and previous cholecystectomy, and between distal colonic cancer and asymptomatic gallstones found concomitantly with the cancer, was noted in the present study. To clarify the relationship between colonic cancer, and cholecystectomy and gallstones, further study of a large number of colonic cancer patients and a prospective study of the incidence of colonic cancer after cholecystectomy are proposed.
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PMID:Relationship between cholecystectomy and colonic cancer in low-risk Japanese population. A preliminary study. 687 77


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