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Query: UMLS:C0024623 (gastric cancer)
 36,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 306 patients, fiberpanendoscopy and radiology were performed within a time interval of 7 days or less. In 196 cases, radiology was performed before endoscopy and in 110 cases after endoscopy. In cases with histologically unproven divergent findings, follow-up studies were performed. In the diagnosis of gastric ulcer and gastric cancer, endoscopy with biopsy was more accurate than radiology. In the diagnosis of hiatal hernia, radiology was more accurate. Important additional findings difficult or impossible to observe with endoscopy were present in 36% of the radiological examinations. Thus, the first examination should be endoscopy when ulcer or carcinoma is suspected. In patients with uncharacteristic epigastric symptoms, radiology should be performed first.
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PMID:[Fiber endoscopy and radiology in stomach ulcer, stomach neoplasms and hiatal hernia: questions, timing and value]. 76 Jan 87

Patients with a wide range of gastrointestinal cancers have been treated with nitrosoureas by the Eastern Cooperative Oncology Group. Methyl-CCNU, CCNU, and streptozotocin have been evaluated as single agents in the treatment of colorectal carcinoma. Methyl-CCNU has had an extensive trial in gastric carcinoma as a single agent and in combination with 5-fluorouracil (5-FU). It has also been used to treat pancreatic carcinoma and, in a few patients, carcinoma of the biliary tract. In gastric cancer it would appear that a synergistic effect on response rates has resulted from the combination of methyl-CCNU and 5-FU. The addition of cyclophosphamide to this combination as an induction agent detracted significantly.
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PMID:Nitrosoureas: useful agents for the treatment of advanced gastrointestinal cancer. 78 99

Heterotopic ossifications are found frequently in rats with nitrosoguanidine-induced carcinomas of the gastric stump. The following steps of differentiation of the desmal ossification in the stump carcinomas are demonstrated: 1. Osteoblasts. 2. Osteoid. 3. Woven Bone reticular network. 4. Lamellar bone. The islands of metaplastic bone cells are predominantly located in the invasive marginal area of the carcinoma of the gastric stump. The histology is similar to that one seen in stomach cancer of men. Therefore, the here described model seems to be suitable for further study of the metaplastic bone formation in the gastrointestinal tract.
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PMID:[Heterotopic ossification in cancer of the stomach. An experimental contribution to a clinical phenomenon (author's transl)]. 80 41

The uninvolved gastric mucosa of gastric ulcer and gastric carcinoma patients has been compared in in vitro studies as regards their capacity to bind demethylchlortetracycline (DMCT). Dialysis experiments demonstrated excessive binding of DMCT in gastric cancer. Several electrophoretic fractions were observed that bound DMCT; it was demonstrated that these fractions differed in the uninvolved mucosa of gastric ulcer and gastric cancer patients.
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PMID:Demethylchlortetracycline-binding proteins in uninvolved gastric mucosa of gastric carcinoma and gastric ulcer patients. Demonstration of a difference between the uninvolved mucosa of ulcer and cancer patients. 82 May 87

Gastric cancer is a common cause of death in the Netherlands. The prognosis is generally poor at the time of diagnosis. The designation early gastric cancer (EGC) refers to a gastric carcinoma which does not infiltrate beyond the submucosa. This definition is not influenced by absence or presence of metastases or by the diameter of the tumour. The 5-year survival of EGC is 90% or more. In the Netherlands too, the diagnosis can regularly be made if--in the case of persistent vague upper abdominal complaints--an optimal radiological examination of the stomach is done. At even the slightest radiological suspicion, or if complaints persist in spite of negative radiological findings, gastroscopic examination and multiple aimed biopsies should follow. Personal observations in ten cases are presented.
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PMID:Early gastric cancer. 84 Oct 21

A review of Caucasian and Hawaiian patients with stomach carcinoma in Honolulu reinforces observations in other racial groups that the Lauren diffuse histopathological type of gastric cancer is more frequent in females and younger patients, while the so-called intestinal type is more common in older patients and men; that the intestinal form has a better prognosis; and that there are more long-term survivors among women than men with diffuse carcinoma. Prognosis and the level of cancer risk are not associated in Hawaii, since Hawaiians share high risk with Japanese and poor prognosis with Caucasians. There is no apparent association of cancer risk with the ratio of intestinal to diffuse forms among Hawaiians, Caucasians, and Japanese. In addition to the known high risk of stomach carcinoma in Hawaiians and Japanese, this study has identified a high risk among people of Portuguese ancestry.
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PMID:Stomach carcinoma among Hawaiians and Caucasians in Hawaii. 87 Jan 73

Gastric carcinomas had various pathological features. Based on patterns of growth and invasiveness, however, they fell into two types; expanding type and infiltrative type. These types were readily recognizable histologically: expanding carcinomas grew en masse and by expansion, resulting in the formation of discrete tumor nodules, whereas in infiltrative carcinoma tumor cells invaded individuality. Both types showed varying degrees of cell maturation, but glands were much more common in expanding carcinoma. The difference in growth pattern was reflected partly by gross appearance of the tumors. These two types of carcinoma appeared to be different in their histogenetic origins. Intestinal metaplasia probably played a role in the development of expanding, but not infiltrative, carcinoma. There were differences also in the sex and age of the patients, survival rate, and epidemiological distribution. Thus, this classification provided a simple basis for evaluation of various aspects of gastric cancer.
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PMID:Gastric carcinoma. A pathobiological classification. 87 47

A prospective study of carcinoma of the stomach and oesophagus has been carried out for 2 1/2 years. Seventy-three cases of carcinoma of the stomach, and 16 cases of carcinoma of the oesophagus have been documented. For carcinoma of the stomach, operability rate was 72-6% and resectability rate was 41-9%; overall survival was poor, 20-9% at 12 months. For those who underwent resection, survival at 12 months was 45-5%. No cases of early gastric cancer are among those studied. For carcinoma of the oesophagus, four patients had a resection, and only one has survived for more than 12 months. In the clinical sphere there is a need for early endoscopic as well as radiological investigation of dyspeptic symptoms. In the research field there is a need for studies of chemotherapy in combination with surgery in the initial treatment of gastric carcinoma.
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PMID:A prospective study of gastric and oesophageal carcinoma. 89 4

Particular method and program of mass survey examination of gastric cancer were introduced into Miyagi Prefecture and the results accumulated during the past 14 years are presented. During this period, 1,427 cases of gastric cancer (0.18%), as well as many cases of other diseases of the stomach and duodenum, were found by the mass survey. 450 cases were those of early cancer in which invasion of carcinoma was limited to the mucosa and submucosa. The ratio of surgically confirmed early cancer cases to all the stomach cancer cases was 36.4%. Almost in all cases of early stomach cancer there were neither complaints nor clinical symptoms; that is, they were the cases of so-called preclinical cancer of the stomach. The prognosis after surgery of early stomach cancer was remarkably favorable with a five-year survival rate over 90% and the death rate due to stomach cancer was actually decreased in the surveyed population.
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PMID:Evaluation of mass screening program for stomach cancer. 96 32

Statistics of postmortem examinations and retrospective long-term observations indicate a disposition of the resected stomach for the development of a primary carcinoma. The risk to develop a carcinoma after resection for peptic ulcer shows a two- to three-fold increase compared to gastric cancer mortality of the normal population. Because of the lack of typical symptoms for gastric stump cancer surgical treatment will occur late and the 5-years survival rate is only 1.38%. The cause of the increased cancer risk after gastric resection seems to be the atrophic gastritis in the gastric remnant which is found after a few years.
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PMID:[Pathogenesis and clinics of gastric stump carcinoma (author's transl)]. 96 9


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