Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024591 (malignant hyperthermia)
 2,353 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
CACNA2 13.7
SH3 and cysteine-rich domain-containing protein 3 12.7
RYR1 12.7
CACNLB1 12.1
dihydropyridine receptor alpha 1 subunit 12.1
STAC3 12.0
CACNA1S 11.8
CACNG1 11.4
CACNL1A3 11.2
RyR1 11.0
CASQ1 10.8
gamma adducin 10.6
calsequestrin 1 10.4
JP-45 10.3
PFK-A 10.0
histidine-rich calcium-binding protein 10.0
CACNB1 10.0
ryanodine receptor 10.0
Cav1.1 10.0
A1BG 9.9
Hox-2.2 9.8
SP-10 9.8
dihydropyridine receptor 9.7
sarcalumenin 9.7
NDUFA11 9.6
MNS 9.6
myoadenylate deaminase 9.5
HE6 9.5
FK506-binding protein 12 9.5
calmitine 9.3
DHPR 9.2
ATP2A1 9.2
MAGE1 9.1
aldehyde oxidase 1 9.0
Calsequestrin 8.9
CYP2F 8.9
CACNA2D1 8.9
C4B2 8.8
Triadin 8.6
Erythropoietin receptor 8.5
RyR2 8.4
hepatic leukemia factor 8.4
alpha-adducin 8.3
SCN4A 8.3
RYR3 8.3
RYR2 8.2
SLC22A8 8.2
junctin 8.2
GYS1 8.1
NDUFB8 8.0
SEPN1 8.0
EA2 7.9
CPK 7.9
DEGS 7.8
sodium channel alpha subunit 7.8
semenogelin I 7.8
DEGS1 7.8
adenosine monophosphate deaminase 7.7
BCL3 7.7
amphiphysin II 7.7
NACA 7.7
C4A3 7.6
HARS 7.6
CYP2A 7.6
SERCA1 7.5
CACNA1F 7.5
LSR 7.5
Melanoma inhibitory activity 7.5
CPT II 7.5
PHS 7.5
CPT2 7.4
muscle glycogen phosphorylase 7.3
cardiac calsequestrin 7.3
TPM3 7.2
BAH 7.1
Fukuyama-type congenital muscular dystrophy 7.1
triadin 7.0
APOC2 7.0
SLCO1B3 6.9
FK-506 binding protein 6.9
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Disease
MHS4 13.7
malignant hyperthermia 13.7
Lethal Catatonia 13.1
Carnitine palmitoyltransferase II deficiency 12.7
Central core disease 12.5
Hyperglycemic hyperosmolar nonketotic syndrome 12.1
Metabolic myopathy 12.1
porcine stress syndrome 12.0
Myoadenylate deaminase deficiency 11.5
Other metabolic disorders 11.4
chronic undifferentiated schizophrenia 10.9
MHS6 10.9
congenital neuromuscular disorder 10.7
normokalemic periodic paralysis 10.6
Myoglobinemia 10.3
ARVD2 10.1
MNS 9.3
periodic paralysis 9.2
alcoholic myopathy 9.0
Hyperkalemic periodic paralysis 9.0
allergic rash 8.9
myotonia congenita 8.8
familial periodic paralysis 8.7
paramyotonia 8.7
NMS 8.6
FSS 8.6
thyroid storm 8.6
PCP abuse 8.6
Hypokalemic periodic paralysis 8.5
multicore 8.2
HSAN IV 8.2
Exertional rhabdomyolysis 8.2
centronuclear myopathy 8.1
psychological disease 7.9
Lobstein 7.9
Acute asthma 7.9
myopathy 7.9
hemiplegic migraine 7.6
respiratory acidosis 7.6
McArdle's disease 7.5
Neuromuscular blockade 7.4
HSAN 7.3
Dental disease 7.1
PHS 7.1
mitochondrial myopathy 7.1
Marcus Gunn 7.0
laryngospasm 6.9
disorders of carbohydrate metabolism 6.9
MELAS 6.8
tranquilizers 6.8
Autonomic dysreflexia 6.8
aspermia 6.8
trismus 6.7
amphetamine abuse 6.6
Trachea 6.6
Trachea 6.6
Trachea 6.6
MELAS 6.5
OHS 6.5
Dent's disease 6.5
Catecholaminergic polymorphic ventricular tachycardia 6.5
camptocormia 6.4
Lambert-Eaton myasthenic syndrome 6.4
SHS 6.4
sinus tachycardia 6.4
SHS 6.4
Neuromuscular blockade 6.4
AN2 6.3
muscular dystrophy 6.3
blepharophimosis 6.2
MBS 6.2
night blindness 6.2
Kugelberg-Welander 6.2
neuromuscular disorder 6.2
CAPA 6.2
DM1 6.1
mesenteric lymphadenitis 6.1
PMD 6.1
diabetic coma 6.0
CPL 5.9
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Symptom
Jaw stiffness 12.7
muscle rigidity 10.6
catatonia 7.5
Excitable 7.3
dark urine 7.2
muscle cramps 7.1
tachypnea 7.0
muscle stiffness 6.8
anesthesia 6.4
spasm 6.4
physical exhaustion 6.4
scaly skin 6.3
jaw pain 6.2
Neurologic symptoms 6.2
clonus 6.2
hypercapnia 6.1
labored breathing 6.0
hypertonia 5.8
cyanosis 5.5
hypotonia 5.5
myalgia 5.5
right lower quadrant pain 5.5
No adverse effect 5.4
twitching 5.0
rigors 5.0
ophthalmoplegia 5.0
Sedation 4.9
weakness 4.8
hypersomnia 4.7
spasticity 4.6
breath holding 4.6
abnormal gait 4.6
excessive sweating 4.5
atypical chest pain 4.4
right upper quadrant pain 4.3
hypothermia 4.0
oliguria 3.9
DNA marker 3.9
chorea 3.7
hypoproteinemia 3.6
ataxia 3.6
dysarthria 3.4
pallor 3.4
lethargy 3.2
flushing 3.1
torticollis 3.1
dystonia 3.0
hypocapnia 3.0
agitation 3.0
memory loss 2.9
collapse 2.7
tremor 2.7
analgesia 2.6
flank pain 2.6
polydipsia 2.6
exhaustion 2.6
bradykinesia 2.5
dysuria 2.5
asthenia 2.4
ENT 2.4
polyuria 2.1
fatigue 2.0
hemiplegia 1.8
regurgitation 1.7
myoclonus 1.7
hepatosplenomegaly 1.6
seizures 1.6
acute stress 1.6
nausea 1.5
nausea and vomiting 1.5
respiratory distress 1.5
paresthesia 1.4
abdominal pain 1.4
vomiting 1.3
Ill 1.3
paresis 1.2
sleepiness 1.1
dyspnea 1.0
cough 0.8
chest pain 0.7
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Drug
Azumolene sodium 13.7
Dantrolene sodium 11.8
Dantrium 11.7
Quelicin 11.7
Alloferin 10.7
Anectine 10.7
Parnate 9.5
Mellaril 9.3
Lioresal 8.1
Sulla 7.8
caffeine 7.6
Ritanserin 7.2
Syntocinon 7.1
Doxapram 7.1
Zmax 6.7
Rocuronium 6.5
Propofol 6.5
Amrinone 5.9
Tubocurarine 5.8
Thioridazine 5.8
CLS 5.5
Premarin 5.5
Fentanyl 5.0
Ringer's solution 4.8
Iohexol 4.7
Ranitidine 4.7
CPR 4.6
Clofibrate 4.6
CPM 4.5
Azithromycin 4.5
Triad 4.4
Cremophor EL 4.4
Triad 4.3
Bupivacaine 4.1
Salbutamol 3.7
Hypaque 3.6
Hypaque 3.5
Ouabain 3.4
MgSO4 3.1
DM1 3.1
Cimetidine 3.0
PCP 2.9
CaCl2 2.7
CaCl2 2.7
CaCl2 2.6
Atropine 2.0
HCH 2.0
PCB 1.7
ENT 1.7
NADH 1.6
ABC 1.6
Ethanol 1.5
Glutathione 1.3
vitamin E 1.2
Mutagen 1.2
EPA 0.9
ampicillin 0.7
nitroglycerin 0.6
Nephron 0.6
Leaf 0.3
Gel -0.1
Monit -0.4
Cardiovasc -0.6
Dermatol -3.3
Enzyme
dihydropteridine reductase 7.9
AMP deaminase 6.6
creatine kinase 6.5
inosine triphosphatase 6.4
spermine synthase 6.2
3-mercaptopyruvate sulfurtransferase 5.8
calcium pump 5.7
CPL 5.7
PST 5.6
adenylate kinase 5.4
guanylate kinase 5.2
Mg2+-ATPase 5.2
DMT 4.8
phosphorylase 4.7
myosin ATPase 4.6
p-nitrophenylphosphatase 4.4
branching enzyme 4.4
CPM 4.3
acrosin 4.3
aequorin 4.2
aldolase 4.0
cathepsin G 3.9
CPT 3.9
monoamine oxidase 3.3
6-phosphogluconate dehydrogenase 3.2
6-phosphogluconate dehydrogenase 3.2
ATPase 3.2
chalcone synthase 3.2
CPT 3.1
phosphoglucose isomerase 3.0
adenosine deaminase 3.0
CPT 3.0
CPR 3.0
ATP synthase 2.9
PCP 2.8
DCF 2.8
AST 2.7
complex I 2.6
N-acetyltransferase 2.5
phospholipase A2 2.5
pyruvate kinase 2.4
myosin light chain kinase 2.3
succinate dehydrogenase 2.3
diaphorase 2.3
aspartate aminotransferase 2.1
5'-nucleotidase 2.1
cholinesterase 2.1
pyruvate dehydrogenase 2.0
prostate-specific antigen 2.0
pyruvate dehydrogenase 2.0
lactate dehydrogenase 1.9
endonuclease 1.9
phosphofructokinase 1.8
NADPH-diaphorase 1.8
calcineurin 1.7
citrate synthase 1.6
hyaluronidase 1.6
DNA methyltransferase 1.4
chloramphenicol acetyltransferase 1.4
deaminase 1.4
pyruvate dehydrogenase 1.3
glutathione peroxidase 1.3
acetylcholinesterase 1.3
diaphorase 1.2
kallikrein 1.2
NQO1 1.1
hyaluronidase 1.1
AMPK 1.1
adenylate cyclase 1.1
acid phosphatase 1.1
glyceraldehyde-3-phosphate dehydrogenase 1.1
thromboplastin 1.0
caspase-9 0.9
glucose-6-phosphate dehydrogenase 0.8
RNase 0.7
cytochrome oxidase 0.6
renin 0.6
RNase 0.6
phosphodiesterase 0.5
glutathione reductase 0.5
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Compound
MHS 13.7
Dantrolene 11.9
Dantrolene sodium 11.8
alpha-Ethyltryptamine 11.4
Noveril 10.4
Succinylcholine 10.4
Anectine 9.8
Halothane 9.4
m-cresol 9.0
Ryanodine 8.7
3-ethylphenol 8.7
Rumensin 8.6
caffeine 7.6
Methoxyflurane 7.4
Mivacurium 7.4
IAS 7.2
Procaine 7.2
Droperidol 7.1
Sevoflurane 7.1
4-ethylphenol 6.9
Glycopyrrolate 6.9
4-vinylphenol 6.8
2-ethylhexanoic acid 6.8
Rocuronium 6.7
Ionophore A23187 6.6
Tranylcypromine 6.6
Isoflurane 6.6
Enflurane 6.5
3-octanone 6.5
SHS 6.5
SDMA 6.5
Etomidate 6.4
Propofol 6.4
Pyridostigmine 6.3
Desflurane 6.3
Ruthenium red 6.3
Atracurium 6.2
Tetracaine 6.2
Emery 6.2
inositol 1,4-bisphosphate 6.1
Mithramycin 6.0
Nitrazepam 6.0
Pancuronium 6.0
CPL 5.9
Tubocurarine 5.9
DCI 5.9
Ropivacaine 5.8
CLS 5.7
1-octen-3-ol 5.6
Procainamide 5.6
MoO4 5.5
Thiopental 5.5
N2O 5.5
phthalazine 5.5
phosphocreatine 5.4
1-propanesulfonic acid 5.4
Premarin 5.4
ADMA 5.3
Creatine 5.3
ethyl carbamate 5.1
Diltiazem 5.0
Diltiazem 5.0
PMP 5.0
cyclopentanone 5.0
cyclopentanone 5.0
cyclopentanone 5.0
cyclopentanone 5.0
Dexmedetomidine 5.0
HCP 4.9
BIC 4.8
DMT 4.8
Coomassie Blue 4.8
Quinacrine 4.6
DMT 4.6
DMD 4.6
CMK 4.5
Midazolam 4.5
Clofibrate 4.5
Cytochalasin D 4.5
CHAPS 4.5
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