Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024591 (malignant hyperthermia)
 2,353 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
RYR1 475
ryanodine receptor 272
Sep 176
RyR1 172
creatine kinase 77
ATP 56
CO2 47
Mol 46
ATPase 41
myoglobin 40
dihydropyridine receptor 37
CPK 30
calmodulin 28
RyR2 26
calcium channel 26
cardiac muscle 26
CACNA1S 25
She 17
MNS 15
endoplasmic reticulum 15
NMR 12
L-type calcium channel 12
Gen 12
insulin 12
Ca2+-ATPase 11
strabismus 11
HEK 10
ADP 8
AMP 8
sodium channel 8
MRI 8
Mil 7
collagen 7
calpain 7
MAC 7
DHPR 7
myosin 7
dystrophin 7
CACNL1A3 6
adenylate kinase 6
more...
Disease
malignant hyperthermia 2353
myopathy 204
stroke 63
hypertension 45
periodic paralysis 41
muscular dystrophy 34
depression 33
Duchenne muscular dystrophy 33
Central core disease 27
NMS 26
scoliosis 26
acute renal failure 25
renal failure 23
DM1 22
coma 22
respiratory acidosis 21
sepsis 20
prolapse 20
cold 19
disseminated intravascular coagulation 19
porcine stress syndrome 18
genetic disorder 18
epilepsy 17
heart failure 17
sepsis 16
MNS 15
SEM 15
Poland 14
cancer 14
BMD 13
Alzheimer's disease 13
multicore 13
myotonia congenita 12
tumor 12
strabismus 12
respiratory failure 12
mitochondrial myopathy 11
tetanus 11
lactic acidosis 11
osteogenesis imperfecta 11
more...
Symptom
anesthesia 688
muscle rigidity 124
weakness 76
spasm 46
hypercapnia 39
pain 27
tachypnea 24
myalgia 22
hypothermia 21
hypotonia 20
seizures 18
catatonia 15
fatigue 15
ataxia 14
collapse 14
cyanosis 13
analgesia 13
spasticity 12
muscle stiffness 10
tremor 9
muscle cramps 9
ophthalmoplegia 8
agitation 7
exhaustion 6
diarrhea 6
abdominal pain 6
vomiting 6
dystonia 5
twitching 5
hypertonia 5
nausea 5
flushing 4
clonus 4
respiratory distress 4
lethargy 4
dyspnea 4
dark urine 3
cough 3
Sedation 3
dysarthria 3
more...
Drug
caffeine 310
Dantrolene sodium 29
Propofol 14
Cardiovasc 10
Ringer's solution 6
NADH 5
Dantrium 5
vitamin E 3
CaCl2 3
Ranitidine 3
CPR 3
Fentanyl 3
CaCl2 3
CaCl2 3
Zmax 2
Azithromycin 2
Nephron 2
ampicillin 2
Monit 2
Ouabain 2
Dermatol 2
Leaf 2
ENT 2
Ritanserin 2
PCP 2
Ethanol 2
ABC 2
Mellaril 1
Lioresal 1
Amrinone 1
Salbutamol 1
DM1 1
Clofibrate 1
Premarin 1
Tubocurarine 1
Gel 1
Syntocinon 1
CPM 1
Atropine 1
MgSO4 1
more...
Enzyme
creatine kinase 128
ATPase 44
phosphorylase 11
lactate dehydrogenase 8
monoamine oxidase 8
dihydropteridine reductase 7
protein kinase 7
aspartate aminotransferase 7
adenylate kinase 6
phospholipase A2 6
endonuclease 5
AMP deaminase 5
CPT 5
acetylcholinesterase 5
alkaline phosphatase 5
glutathione peroxidase 4
calcineurin 4
aldolase 4
Mg2+-ATPase 4
renin 4
complex I 4
cholinesterase 4
ATP synthase 4
calcium pump 4
CPR 3
ERK 3
AST 3
succinate dehydrogenase 3
adenosine deaminase 3
adenylate cyclase 3
peroxidase 3
PST 3
phosphodiesterase 2
acid phosphatase 2
alanine aminotransferase 2
prostate-specific antigen 2
PCP 2
aequorin 2
AMPK 2
RNase 2
more...
Compound
calcium 502
caffeine 310
MHS 275
sodium 170
Dec 142
Clin 140
oxygen 113
Dantrolene 110
CO2 86
Halothane 66
DNA 65
ATP 56
potassium 49
water 38
Ryanodine 32
Succinylcholine 31
His 29
glucose 26
Dantrolene sodium 25
Mg2+ 25
arginine 24
m-cresol 24
phosphate 20
N2O 18
phosphocreatine 16
noradrenaline 15
sulfate 14
creatinine 14
Propofol 14
phosphorus 14
leucine 11
ADP 10
AMP 9
cysteine 8
salt 8
ADP 8
ADP 8
Lactate 8
hydrogen 7
Sevoflurane 7
more...