Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024591 (malignant hyperthermia)
 2,353 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
RYR1 475
ryanodine receptor 272
Sep 176
RyR1 172
creatine kinase 77
ATP 56
CO2 47
Mol 46
ATPase 41
myoglobin 40
dihydropyridine receptor 37
CPK 30
calmodulin 28
cardiac muscle 26
RyR2 26
calcium channel 26
CACNA1S 25
She 17
MNS 15
endoplasmic reticulum 15
Gen 12
L-type calcium channel 12
NMR 12
insulin 12
Ca2+-ATPase 11
strabismus 11
HEK 10
AMP 8
sodium channel 8
ADP 8
MRI 8
DHPR 7
MAC 7
myosin 7
calpain 7
dystrophin 7
collagen 7
Mil 7
adenylate kinase 6
CACNL1A3 6
STAC3 6
membrane protein 6
hemoglobin 6
myoadenylate deaminase 5
NADH 5
FKBP12 5
alkaline phosphatase 5
X-linked 5
SP-10 5
endonuclease 5
5-hydroxytryptamine 5
microsomal 5
muscle glycogen phosphorylase 5
acetylcholinesterase 5
CASQ1 5
SCN4A 5
Calsequestrin 5
growth hormone 5
phospholipase A2 5
beta 1 4
GPI 4
RYR2 4
lactate dehydrogenase 4
MELAS 4
triadin 4
chloride channel 4
PHS 4
renin 4
sperm protein 4
aspartate aminotransferase 4
LDH 4
SERCA1 4
glutathione peroxidase 4
DP1 4
CCD 3
MRS 3
TEM 3
Mal 3
5-HT2 receptor 3
ICP 3
Creatine kinase 3
alpha-adducin 3
FK506-binding protein 12 3
CPT II 3
MIM 3
cytoskeletal protein 3
CPR 3
CYP2A 3
Rec 3
spermatozoa 3
calreticulin 3
ATP synthase 3
AST 3
calcineurin 3
non-muscle 3
PST 3
dystrophin gene 3
reserved 3
ASA 3
PSE 3
serum albumin 3
adenylate cyclase 3
peroxidase 3
HLA 3
muscle specific 3
AES 3
calsequestrin 1 3
Cav1.1 3
major histocompatibility complex 3
LDH-A 2
DVB 2
STIM1 2
heat shock protein 2
HAL 2
LSR 2
FK506 2
STS 2
dimeric 2
A1BG 2
RyR3 2
NRK 2
acid phosphatase 2
methyltransferase 2
CPT 2
SR protein 2
serine protease 2
DEGS1 2
Polymerase 2
SEPN1 2
ACTH 2
prostate-specific antigen 2
HLA-DR4 2
cage 2
PCP 2
prostate specific antigen 2
pyruvate kinase 2
COX 2
cAMP-dependent protein kinase 2
thromboplastin 2
BMD 2
B15 2
BCL3 2
sarcalumenin 2
estrogen receptor 2
DR4 2
JAMA 2
DMD 2
IgE 2
CACNA2 2
DM1 2
TPM3 2
MyoD 2
HHS 2
calcium pump 2
CPT2 2
ABC 2
Pol 2
membrane-bound 2
RNase 2
phosphodiesterase 2
more...
Disease
malignant hyperthermia 2353
myopathy 204
stroke 63
hypertension 45
periodic paralysis 41
muscular dystrophy 34
Duchenne muscular dystrophy 33
depression 33
Central core disease 27
scoliosis 26
NMS 26
acute renal failure 25
renal failure 23
DM1 22
coma 22
respiratory acidosis 21
prolapse 20
sepsis 20
disseminated intravascular coagulation 19
cold 19
genetic disorder 18
porcine stress syndrome 18
epilepsy 17
heart failure 17
sepsis 16
MNS 15
SEM 15
Poland 14
cancer 14
Alzheimer's disease 13
BMD 13
multicore 13
myotonia congenita 12
strabismus 12
respiratory failure 12
tumor 12
dysplasia 11
osteogenesis imperfecta 11
tetanus 11
lactic acidosis 11
thyroid storm 11
mitochondrial myopathy 11
muscular atrophy 10
cleft palate 9
cardiomyopathy 9
tranquilizers 9
ventricular fibrillation 9
hepatitis 9
myocardial infarction 9
trismus 9
Syndrome 9
bronchospasm 9
sinus tachycardia 8
FSS 8
psychosis 8
mental retardation 8
McArdle's disease 8
hemiplegic migraine 8
ischemia 8
mental retardation 8
schizophrenia 8
coagulopathy 7
ECT 7
MAC 7
essential hypertension 7
encephalopathy 7
neuromuscular disorder 7
fits 7
Charcot-Marie-Tooth disease 7
confusion 7
diabetes 6
centronuclear myopathy 6
anaphylaxis 6
sudden infant death syndrome 6
myasthenia gravis 6
paramyotonia 6
pneumonia 6
HIV 6
migraine 6
compartment syndrome 6
akinesia 6
mitochondrial disease 6
alcoholism 5
myositis 5
long QT syndrome 5
influenza 5
asthma 5
hypercalcemia 5
hydrocephalus 5
night blindness 5
pneumothorax 5
Neuromuscular blockade 5
congenital disorder 5
laryngospasm 5
developmental delay 5
Best 5
alcoholic myopathy 4
subarachnoid hemorrhage 4
pulmonary edema 4
cirrhosis 4
Williams syndrome 4
pulmonary embolism 4
congestive heart failure 4
PHS 4
rare disease 4
MELAS 4
Epstein 4
hypoglycemia 4
multiple sclerosis 4
myasthenia 4
hyperthyroidism 4
delirium 4
cerebral palsy 4
bipolar disorder 4
dehydration 4
dysphagia 4
deafness 4
glycogen storage disease 4
pulmonary hypertension 4
Lambert-Eaton myasthenic syndrome 4
Reye's syndrome 4
wasting 4
MELAS 4
hernia 4
Hypokalemic periodic paralysis 3
ICP 3
aggression 3
TEM 3
CCD 3
liver disease 3
Myoadenylate deaminase deficiency 3
emotional stress 3
ventricular septal defect 3
blindness 3
Graves' disease 3
virus infection 3
movement disorder 3
dementia 3
acute appendicitis 3
hyperglycemia 3
sympathomimetic 3
polymyositis 3
AIDS 3
cystic fibrosis 3
meningitis 3
hypertrophic cardiomyopathy 3
acute lymphoblastic leukemia 3
MRS 3
CCD 3
thyrotoxicosis 3
neurological disease 3
renal disease 3
aortic regurgitation 3
TEM 3
uterus 3
Burkitt's lymphoma 3
pheochromocytoma 3
Bartter's syndrome 3
neuropathy 3
mental illness 3
more...
Symptom
anesthesia 688
muscle rigidity 124
weakness 76
spasm 46
hypercapnia 39
pain 27
tachypnea 24
myalgia 22
hypothermia 21
hypotonia 20
seizures 18
catatonia 15
fatigue 15
collapse 14
ataxia 14
analgesia 13
cyanosis 13
spasticity 12
muscle stiffness 10
muscle cramps 9
tremor 9
ophthalmoplegia 8
agitation 7
vomiting 6
diarrhea 6
abdominal pain 6
exhaustion 6
twitching 5
dystonia 5
nausea 5
hypertonia 5
dyspnea 4
respiratory distress 4
lethargy 4
clonus 4
flushing 4
Sedation 3
dysarthria 3
dark urine 3
cough 3
abnormal gait 2
sleepiness 2
ENT 2
hypersomnia 2
Ill 2
regurgitation 2
memory loss 2
chest pain 2
chorea 2
nausea and vomiting 2
oliguria 2
pallor 2
headache 2
rigors 2
dizziness 1
DNA marker 1
asthenia 1
breath holding 1
acute stress 1
stigma 1
hypoproteinemia 1
atypical chest pain 1
angina 1
hypocapnia 1
dysuria 1
overweight 1
paresis 1
insomnia 1
polyuria 1
discomfort 1
flank pain 1
hemiplegia 1
bradykinesia 1
torticollis 1
polydipsia 1
right upper quadrant pain 1
Jaw stiffness 1
scaly skin 1
paresthesia 1
myoclonus 1
right lower quadrant pain 1
discomfort 1
jaw pain 1
low back pain 1
Excitable 1
labored breathing 1
No adverse effect 1
physical exhaustion 1
hepatosplenomegaly 1
excessive sweating 1
Neurologic symptoms 1
Drug
caffeine 310
Dantrolene sodium 29
Propofol 14
Cardiovasc 10
Ringer's solution 6
NADH 5
Dantrium 5
CaCl2 3
CaCl2 3
CaCl2 3
Fentanyl 3
vitamin E 3
CPR 3
Ranitidine 3
Azithromycin 2
Nephron 2
Ouabain 2
Monit 2
ampicillin 2
ENT 2
PCP 2
Dermatol 2
Leaf 2
Ritanserin 2
ABC 2
Zmax 2
Ethanol 2
Mellaril 1
Doxapram 1
Lioresal 1
Amrinone 1
Salbutamol 1
DM1 1
Clofibrate 1
Premarin 1
Tubocurarine 1
Gel 1
Syntocinon 1
Atropine 1
MgSO4 1
Quelicin 1
CPM 1
Triad 1
Cimetidine 1
Azumolene sodium 1
CLS 1
Parnate 1
Glutathione 1
Hypaque 1
Bupivacaine 1
Mutagen 1
Sulla 1
Cremophor EL 1
EPA 1
Alloferin 1
Triad 1
Rocuronium 1
nitroglycerin 1
PCB 1
HCH 1
Hypaque 1
Iohexol 1
Thioridazine 1
Anectine 1
Enzyme
creatine kinase 128
ATPase 44
phosphorylase 11
lactate dehydrogenase 8
monoamine oxidase 8
protein kinase 7
dihydropteridine reductase 7
aspartate aminotransferase 7
adenylate kinase 6
phospholipase A2 6
AMP deaminase 5
CPT 5
endonuclease 5
alkaline phosphatase 5
acetylcholinesterase 5
cholinesterase 4
aldolase 4
renin 4
calcineurin 4
Mg2+-ATPase 4
calcium pump 4
glutathione peroxidase 4
complex I 4
ATP synthase 4
PST 3
AST 3
CPR 3
ERK 3
adenylate cyclase 3
adenosine deaminase 3
succinate dehydrogenase 3
peroxidase 3
thromboplastin 2
acid phosphatase 2
phosphodiesterase 2
alanine aminotransferase 2
RNase 2
prostate-specific antigen 2
PCP 2
pyruvate kinase 2
aequorin 2
trypsin 2
cathepsin G 2
mitogen-activated protein kinase 2
AMPK 2
RNase 2
myosin ATPase 2
CPT 2
CPT 2
superoxide dismutase 1
NADPH-diaphorase 1
NO synthase 1
pyruvate dehydrogenase 1
deaminase 1
phosphofructokinase 1
focal adhesion kinase 1
guanylate kinase 1
diaphorase 1
pyruvate dehydrogenase 1
catalase 1
hyaluronidase 1
pyruvate dehydrogenase 1
hyaluronidase 1
CPM 1
myosin light chain kinase 1
DMT 1
reverse transcriptase 1
CPL 1
caspase-9 1
spermine synthase 1
6-phosphogluconate dehydrogenase 1
glucose-6-phosphate dehydrogenase 1
3-mercaptopyruvate sulfurtransferase 1
branching enzyme 1
luciferase 1
RNA polymerase 1
chloramphenicol acetyltransferase 1
NQO1 1
p-nitrophenylphosphatase 1
kallikrein 1
AMP-activated protein kinase 1
6-phosphogluconate dehydrogenase 1
N-acetyltransferase 1
lysozyme 1
phosphoglucose isomerase 1
diaphorase 1
DCF 1
glutathione reductase 1
DNA polymerase 1
5'-nucleotidase 1
MEK 1
glyceraldehyde-3-phosphate dehydrogenase 1
acrosin 1
citrate synthase 1
DNA methyltransferase 1
ACE 1
inosine triphosphatase 1
chalcone synthase 1
cytochrome oxidase 1
Compound
calcium 502
caffeine 310
MHS 275
sodium 170
Dec 142
Clin 140
oxygen 113
Dantrolene 110
CO2 86
Halothane 66
DNA 65
ATP 56
potassium 49
water 38
Ryanodine 32
Succinylcholine 31
His 29
glucose 26
Mg2+ 25
Dantrolene sodium 25
arginine 24
m-cresol 24
phosphate 20
N2O 18
phosphocreatine 16
noradrenaline 15
phosphorus 14
creatinine 14
sulfate 14
Propofol 14
leucine 11
ADP 10
AMP 9
salt 8
Lactate 8
ADP 8
ADP 8
cysteine 8
Sevoflurane 7
Isoflurane 7
ethanol 7
hydrogen 7
5-HT 7
glycerol 6
nitrogen 6
Procaine 5
bromide 5
A 3 5
NADH 5
Gly 4
Verapamil 4
Ile 4
Optimal 4
Verapamil 4
stearic acid 4
urea 4
glucose-6-phosphate 4
chloroform 4
ASA 4
threonine 4
glutamate 4
ammonia 3
tyrosine 3
proline 3
serine 3
PEG 3
selenium 3
Diltiazem 3
Isoproterenol 3
Diltiazem 3
tryptophan 3
Ruthenium red 3
stearic acid 3
CaCl2 3
Droperidol 3
tryptophan 3
Sodium 3
carbonate 3
Nifedipine 3
Lidocaine 3
acetate 3
tryptophan 3
Creatine 3
tryptophan 3
TEM 3
stearic acid 3
prostaglandin E1 3
nicotinamide 3
cAMP 3
IAS 3
Dexmedetomidine 2
CPT 2
4-vinylphenol 2
Guo 2
methionine 2
Phe 2
alanine 2
Propranolol 2
Cocaine 2
Salt 2
HCl 2
COX 2
sodium chloride 2
oxalate 2
6-12 2
ethyl carbamate 2
CPT 2
DMSO 2
N-acetylcysteine 2
DMD 2
methanol 2
PCP 2
Lactic acid 2
ACTH 2
4-ethylphenol 2
TMB 2
Etomidate 2
barium 2
Propranolol 2
MgO 2
Cardiol 2
Inositol 2
zinc 2
iron 2
CHAPS 2
pentane 2
nitric oxide 2
TCA 2
DSM 2
Enflurane 2
mercury 2
Emery 2
SDS 2
FK506 2
1-octen-3-ol 2
Ketamine 2
Norepinephrine 2
BMD 2
Neuronal 2
Oleic acid 2
Ouabain 2
Carbachol 2
Midazolam 2
pentose 1
DMT 1
A 42 1
MNNG 1
Hearts 1
Chloroquine 1
Atropine 1
Ionophore A23187 1
Amphetamine 1
benzaldehyde 1
prostacyclin 1
GSSG 1
GPT 1
benzaldehyde 1
benzaldehyde 1
cyclopentanone 1
benzaldehyde 1
more...