Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0024591 (
malignant hyperthermia
)
2,353
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
transient receptor potential vanilloid 1
(
TRPV1
) belongs to the transient receptor potential superfamily of sensory receptors.
TRPV1
is a non-selective cation channel permeable to Ca
2+
that is capable of detecting noxious heat temperature and acidosis. In skeletal muscles,
TRPV1
operates as a reticular Ca
2+
-leak channel and several
TRPV1
mutations have been associated with two muscle disorders:
malignant hyperthermia
(MH) and exertional heat stroke (EHS). Although
TRPV1
-/-
mice have been available since the 2000s,
TRPV1
's role in muscle physiology has not been thoroughly studied. Therefore, the focus of this work was to characterize the contractile phenotype of skeletal muscles of
TRPV1
-deficient mice at rest and after four weeks of exercise. As MS and EHS have a higher incidence in men than in women, we also investigated sex-related phenotype differences. Our results indicated that, without exercise,
TRPV1
-/-
mice improved in vivo muscle strength with an impairment of skeletal muscle in vitro twitch features, i.e., delayed contraction and relaxation. Additionally, exercise appeared detrimental to
TRPV1
-/-
slow-twitch muscles, especially in female animals.
...
PMID:The Contractile Phenotype of Skeletal Muscle in TRPV1 Knockout Mice is Gender-Specific and Exercise-Dependent. 3303 39
