Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
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Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0024591 (
malignant hyperthermia
)
2,353
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The activity of enzymes transporting calcium across the membrane of the muscle fibre and sarcoplasmic reticulum was studied. The activity of actomyosin Mg2+-ATPase and the composition of troponin were investigated also. In seven Pietrain pigs halothane alone or with suxamethonium induced the
malignant hyperthermia
syndrome. In the animals with
malignant hyperthermia
Ca2+-ATPase was not activated in the plasma membranes of the muscle fibres, when compared with control animals (n = 4). An increase of Ca2+-ATPase of the sarcoplasmic reticulum was observed in animals with
malignant hyperthermia
; the opposite was noted in the control group. No significant changes in the activity of Mg2+-ATPase of the sarcoplasmic reticulum and of Mg2+-ATPase of actomyosin were observed after exposure to halothane in control pigs and those with
malignant hyperthermia
. The amount of
troponin C
was significantly changed in the animals with
malignant hyperthermia
. The mechanism of the development of
malignant hyperthermia
syndrome is discussed.
...
PMID:Experimental porcine malignant hyperthermia: the activity of certain transporting enzymes and myofibrillar calcium-binding protein content in the muscle fibre. 612 63
