Gene/Protein
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Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UMLS:C0024591 (
malignant hyperthermia
)
2,353
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Strandard laboratory rabbits which are not genetically susceptible to
malignant hyperpyrexia
were anesthetized with either halothane or pentobarbital. Administration of caffeine in 125 mg increments produced a syndrome strongly resembling
malignant hyperpyrexia
in rabbits anesthetized with halothane. All these animals became rigid, hyperpyrexic, acidotic and hyperkalemic, whereas caffeine-treated, pentobarbital-anesthetized animals developed only mild acidosis.
Pentobarbital
alone and halothane alone caused no changes in measured variables. This model for
malignant hyperpyrexia
resembles the naturally occurring disease more closely than several preceding pharmacologic models.
...
PMID:A laboratory animal model for malignant hyperpyrexia. 3 78
