Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024591 (malignant hyperthermia)
 2,353 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Winnie and co-workers described a technique of blocking the lateral cutaneous nerve of thigh, femoral and obturator nerves using one injection of local anaesthetic into the fibrous sheath surrounding the femoral nerve. We studied 40 patients undergoing biopsy of vastus medialis for investigation of malignant hyperpyrexia, for onset, quality and recovery from this block. The patients were assigned in a random double-blind fashion to receive 0.6 ml kg-1 of one of two anaesthetic solutions: 1% lignocaine with 1 in 100,000 noradrenaline or 0.25% bupivacaine. Bupivacaine produced a similar onset time but longer duration of action compared with lignocaine. Median peak plasma concentrations of six patients in each group did not approach values associated with toxicity. This study demonstrated a 12.5% and 87.5% partial and complete femoral nerve block, respectively, and a 67.5% success rate for lateral cutaneous nerve of thigh using Winnie's technique. There was no clinical evidence of obturator nerve block.
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PMID:Evaluation of "3 in 1" lumbar plexus block in patients having muscle biopsy. 273 Aug 23