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Query: UMLS:C0024591 (malignant hyperthermia)
 2,353 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lactic acid, glucose, creatine phosphokinase (CPK) and some mineral components were determined in the blood of piglets before and after a halothane test of five minutes (only before for CPK). Two different experimental groups were studied: 222 Pietrain piglets from an INRA experimental herd, and 325 piglets from the Large White, French Landrace and Belgian Landrace breeds entering performance testing stations. Animals reacting positively to halothane ("MHS" piglets) have significantly higher blood levels of lactic acid and potassium before anesthesia than normal animals. CPK is also higher, except for the Belgian Landrace: in this breed CPK shows the same average value and distribution in the two groups of piglets (normal and MHS). There are also breed differences in blood magnesium, independently of the reaction to halothane. But the breed differences observed in lactic acid and CPK are related to the proportion of MHS piglets in each breed. Anesthesia by means of halothane lowers the measured blood characteristics--except for glucose--in normal animals, and rises them--except for potassium--in MHS piglets. The results are discussed in view of the incomplete discrimination between the two types of pigs, with a 5 minutes test, and, particularly, considering possible breed differences in that respect.
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PMID:[Blood characteristics of some french pig populations. Relationships with the malignant hyperthermia syndrome (author's transl)]. 54 25

(1)H-NMR has been used to study the evolution of water proton transversal relaxation times in ageing skeletal muscles of normal and halothane-positive Pietrain pigs. Malignant hyperthermia was confirmed by the caffeine contracture test. Lactic acid, creatine phosphate, and ATP levels in muscle biopsies were measured by biochemical analysis. The NMR dynamic results revealed malignant hyperthermia, but knowledge of animal age and muscle type improved significantly the detection ability. The NMR results revealed large differences between muscles. Halothane sensitivity detection seems to be less affected by animal age, than by muscle effect but discrimination was more efficient in the older animal group. It is concluded that (1) H-NMR is a suitable method for diagnosing halothane sensitivity on a well identified muscle biopsy and that water dynamics might be related to acidosis in muscle fibres.
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PMID:NMR relaxation of water protons in normal and malignant hyperthermia-susceptible pig muscle. 2205 42