Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024591 (malignant hyperthermia)
 2,353 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Erythrocyte fragility of malignant hyperthermia-susceptible and resistant pigs has been examined as a function of pH and temperature in the absence and presence of halothane and its metabolites. A decrease in pH from 7.40 to 6.95 increased the fragility of both susceptible and resistant pigs, but the increase in susceptible animals was significantly greater than that in resistant animals. An increase in temperature led to a reduction of erythrocyte fragility of both types of pig. The most consistent differences in haemolysis between susceptible and resistant pigs occurred at sodium chloride concentrations of 0.120 and 0.137 mol litre-1. At all pH values examined and at 39 and 41 degrees C, but not at 43 degrees C, erythrocytes from susceptible pigs showed greater haemolysis in sodium chloride 0.120 and 0.137 mol litre-1 than did erythrocytes from resistant pigs. Halothane or its metabolites, at concentrations occurring during anaesthesia, did not alter erythrocyte fragility.
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PMID:Influence of pH, temperature, halothane and its metabolites on osmotic fragility of erythrocytes of malignant hyperthermia-susceptible and resistant pigs. 723 74

A 65-year-old man underwent parathyroidectomy for hyperparathyroidism secondary to renal failure. Intra-operatively he received methylene blue infusion (7.5 mg.kg(-1), a total of 650 mg in 500 ml 0.9% sodium chloride) for visualisation of parathyroid glands. At the end of surgery, following extubation he developed agitation, intense shivering and hyperpyrexia, and his level of consciousness decreased to a Glasgow Coma score of 7. The differential diagnoses included methylene blue toxicity or malignant hyperpyrexia. His lungs were ventilated, and intravenous dantrolene was administered to control hyperpyrexia. Haemodialysis was started to remove the methylene blue dye. We review the literature on the pharmacological actions of methylene blue, and discuss the differential diagnosis and management of this patient.
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PMID:Hyperpyrexia and prolonged postoperative disorientation following methylene blue infusion during parathyroidectomy. 1715 45