Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024591 (malignant hyperthermia)
 2,353 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The parathyroid hypertensive factor (PHF) is present in the plasma of SHR rats. The authors of this study set out to determine whether this factor was also present in the Lyon (LH male and female) and Milan (MHS male) hypertensive rats. Five week old normotensive rats (LN and MNS) were transplanted with the parathyroid glands of LH and MHS rats immediately after parathyroidectomy (PTX). Plasma calcium fell rapidly after PTX but returned to physiological levels, confirming the functional activity of the graft. Systolic blood pressures of transplanted rats were significantly higher than normotensive LN and MNS controls. These results confirm the role of the parathyroid glands in the genesis of hypertension in Lyon and Milan male and female rats. They suggest that PHF may be implicated in the hypertensive mechanisms of these two models of genetic hypertension.
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PMID:[Genetic hypertension in the rat is partially dependent of parathyroid glands. Results of a crossed transplantation trial]. 812 28

Although everybody agrees that each individual's blood pressure variance is under substantial genetic control, its quantitative estimates vary from 35 to 70%, according to the different experimental designs. The problem is that, in spite of such substantial contribution, the discovery of the "genes that cause hypertension" has been quite discouraging. This is indeed caused by the multifactorial nature of the disease and no improvement is to be expected without dissecting hypertension in its major pathogenetic pathways. As a paradigm of such a dissection, we present the data on adducin system, that proved to be relevant for a common form of salt sensitive in humans and the genetic hypertension of MHS rats.
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PMID:Genetics of human arterial hypertension. 1469 69