Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0024591 (malignant hyperthermia)
 2,353 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

As is illustrated in the case report presented here, disorders other than malignant hyperthermia can lead to fever and tachydysrhythmias. Should such symptoms develop in a patient with a previous history of thyrotoxicosis, the possibility of thyroid storm should be considered. Careful monitoring must not cease with the termination of the operation, because this complication usually develops after surgery. Should the complication occur, a successful outcome is dependent upon an understanding of the pathophysiology of the disease process, aggressive monitoring, and appropriate pharmacological management.
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PMID:A case approach: the pathophysiology of thyroid storm. 619 71

Three women were consecutively admitted to our medical intensive care unit for thyrotoxicosis after the ingestion of dietary pills accidentally containing high levels of thyroxin. These cases were observed during an outbreak in the Paris area. Despite similar blood levels of thyroid hormones, their clinical presentation and outcome were very different. One patient developed febrile confusion and died from malignant hyperthermia. The second one had progressive confusion requiring mechanical plasma exchange therapy and had a favorable outcome. The third one had very moderate symptoms. These exceptional observations raise several issues concerning diagnosis, physiopathology and treatment of thyrotoxicosis factitia.
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PMID:A thyrotoxicosis outbreak due to dietary pills in Paris. 1933 45

Thyroid storm, a severe complication of hyperthyroidism, can be a devastating medical emergency requiring rapid management. Intraoperative thyrotoxicosis, a hypermetabolic syndrome with increased thyroid hormone levels, also presents a challenging scenario. Clinical suspicion is key along with eliminating other potentially catastrophic emergencies such as malignant hyperthermia or pheochromocytoma. In this case report, we describe a 15-year-old male undergoing halo traction placement for displaced dens and C1 fractures. Preoperative tachycardia and a history suggestive of hyperthyroidism raised our clinical suspicion for thyrotoxicosis when hypertension and tachycardia developed after induction of anesthesia.
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PMID:Intraoperative diagnosis and treatment of thyroid storm in a 15-year-old male. 2561 58