Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024591 (malignant hyperthermia)
 2,353 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Virus-like particles (VLP) have been identified by electronmicroscopy in the skeletal muscles (paraxials) of six cases of idiopathic scoliosis. These particles closely resembled VLP reported in the skeletal muscles in other conditions, e.g. Reye's syndrome, polymyositis, malignant hyperthermia, and chronic myopathy. We have shown by specific staining that these structures are composed of glycogen in a crystalline form. Using Coxsackie B infected tissue culture cells as a control we have shown that these viruses, which are of similar shape and size to the VLP, were unstained using this specific staining method.
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PMID:The nature of virus-like particles in the paraxial muscles of idiopathic scoliosis. 23 Mar 31

The occurrence in a previously healthy infant of sudden febrile encephalopathy with shock and metabolic acidosis associated with liver and renal failure and bloody watery diarrhea has been reported by several authors in recent years. We report the same association in a 3 1/2 month-old infant. We discuss the similarities between this clinical picture and malignant hyperthermia and Reye syndrome.
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PMID:[Hemorrhagic shock syndrome with encephalopathy]. 357 85

Auditory and somatosensory EPS obtained after median nerve stimulation are an interesting approach for the central nervous system investigation. However, there are some problems of interpretation during the first year of life, related to the maturation of the nervous system. We studied 20 severely comatose children aged 8 months to 15 years, admitted in an intensive care unit. Most of them were intubated, mechanically ventilated and received high doses of barbiturates. Coma was related to severe head injury, meningitis, encephalitis, Reye syndrome, malignant hyperthermia, cerebral lymphoma. Normal EP are correlated with a good recovery. Patients with abnormal EP may die or exhibit neurological sequelae. The absence of somatosensory EP is correlated with a bad outcome and is generally related to cerebral oedema. Appreciation of the prognosis in comatose children may be improved by repeated determination of auditory and somatosensory EP.
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PMID:[Evoked potentials in comatose children]. 358 78

When assessing an acute coronary syndrome (ACS) by means of high serum levels of creatine kinase (CK) and its MB fraction (CK-MB), one must keep in mind that there are several other causes for an increase of these markers, such as myocarditis, pericarditis, heart failure, severe aortic stenosis, stroke, renal failure, malignant hyperthermia, Reye syndrome, polymyositis, and borreliosis (1). Also, there are cases when CK-MB is falsely increased due to certain abnormalities that occur in the CK isoenzymes. One such example is the formation of the so-called macro-creatine kinase complexes (macro-CK) that give a false increase of the CK-MB fraction. We report two clinical cases where macro-CK was the cause of apparent increase in serum CK and CK-MB: in a 79-year old male with a history of coronary disease and a 82-year old female with permanent atrial fibrillation.
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PMID:Macro-creatine kinase syndrome as an underdiagnosed cause of ck-mb increase in the absence of myocardial infarction: two case reports. 2370 Aug 84