Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0024591 (malignant hyperthermia)
 2,353 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Auditory and somatosensory EPS obtained after median nerve stimulation are an interesting approach for the central nervous system investigation. However, there are some problems of interpretation during the first year of life, related to the maturation of the nervous system. We studied 20 severely comatose children aged 8 months to 15 years, admitted in an intensive care unit. Most of them were intubated, mechanically ventilated and received high doses of barbiturates. Coma was related to severe head injury, meningitis, encephalitis, Reye syndrome, malignant hyperthermia, cerebral lymphoma. Normal EP are correlated with a good recovery. Patients with abnormal EP may die or exhibit neurological sequelae. The absence of somatosensory EP is correlated with a bad outcome and is generally related to cerebral oedema. Appreciation of the prognosis in comatose children may be improved by repeated determination of auditory and somatosensory EP.
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PMID:[Evoked potentials in comatose children]. 358 78

An adult patient with massive abdominal Burkitt's lymphoma developed malignant hyperthermia during exploratory laparotomy. Simultaneously, evidence of tumor lysis appeared. The lethal effect of heat on cancer cells has been amply demonstrated experimentally, and clinical trials of regional and whole-body hyperthermia in various human malignancies have appeared. Lymphomas have not been reported among those tumors studied. Burkitt's lymphoma, a rapidly growing tumor, is likely to respond to hyperthermia, and the evidence reported here should be pursued with controlled clinical trials involving induced hyperthermia in refractory malignant lymphomas.
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PMID:Burkitt's lymphoma: tumor lysis following malignant hyperthermia. 740 66