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Query: UMLS:C0024530 (malaria)
 44,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Transfusional malaria is an unusual disease. Any fever, happening immediately after blood transfusions must evoke this diagnosis, confirmed by parasites detection in the blood. The treatment is rapidly efficacious. The prophylaxis is at the present time insufficient and would require fluorescent antibody test generalization.
Sem Hop
PMID:[Transfusional malaria. Another case (author's transl)]. 22 66

Four severe cases of imported malaria are reported here. Three of them are pernicious and the fourth is a black water fever (hemoglobinuria). The difficulties of initial diagnosis are exposed. There was no mortality in these four cases which represent the annual recruiting of a multipurpose intensive care unit. But the complications are severe in contradiction with easy effective chemoprophylaxis. The principles of treatment and prophylaxis are resumed in the light of these four observations.
Sem Hop
PMID:[Severe forms of imported malaria concerning three pernicious attacks and a black water fever (hemoglobinuria) (author's transl)]. 23 May 88

Non hemodynamic pulmonary edemas included by some authors in the acute respiratory distress syndrome (ARDS) had been reported in cerebral malaria. We describe a new case. Clinical data, hemodynamic studies with PWP measurement, and anatomic findings are coherent with the diagnosis of ARDS. Although the underlying causal mechanisms--the marked parasitemia and its consequence on permeability of the pulmonary capillary--remain speculative, they seem credible. The pulmonary lesions are provoked by these main factors and worsened by hypoprotidemia and surinfection. Prevention of all these factors can stop the evolution towards refractory hypoxemia but the precocity of quinine treatment remains the most important point.
Sem Hop
PMID:[Acute respiratory distress syndrome (ARDS) in cerebral malaria (author's transl)]. 624 89

In the Bacteriology-Parasitology laboratory of CHU in Rouen, we diagnosed from 1970 to 1978: 49 cases of imported malaria and 3 cases following transfusion of blood by finding of erythrocytic parasite. It is necessary to report: 26 more cases, diagnosed by immunologic test (IFI) which, being the total number reported to 78. 71,5% of the cases of imported malaria were caused by Plasmodium falciparum, including one fatal case of cerebral malaria. Patients were europeans (45%) and immigrants living in Rouen (55%) who were returning from an endemic area and did not receive chemoprophylaxis or did not take it correctly. In front of actual increasing number of imported malaria cases, it is essential to inform travellers on the risk involved and importance of chemoprophylaxis.
Sem Hop
PMID:[Imported malaria at the CHU in Rouen (author's transl)]. 626 71

The diagnostic problems which arise when fever occurs in a patient returning from black Africa are more and more frequently encountered because of the multiplication of rapid connections with this continent. Analysis of the main etiologies leads the author to review most of the specifically tropical diseases. However, cosmopolitan diseases should not be underrated. The author emphasizes the high incidence of pernicious malaria, liver amebiasis, and typho-paratyphoid fevers, along with the necessity of keeping in mind the new viral diseases (Lassa, Marburg, Ebola).
Sem Hop 1982 Feb 18
PMID:[Diagnosis of fever in a patient returning from black Africa (author's transl)]. 628 Mar 18

When P. falciparum malaria is diagnosed in France in a patient who has not travelled to an endemic area, transmission by blood transfusion or direct contact with an infected person, and indigenous malaria should be considered. With reference to the observation reported in this paper, the manifestations of malarial hepatitis are recalled and their diagnostic significance is discussed. In P. falciparum malaria, malarial hepatitis indicates the development of a complete cycle including the pre-erythrocytic phase; this is strongly in support of indigenous malaria, and against malaria following blood transfusion or direct contact in which there is no pre-erythrocytic phase.
Sem Hop 1982 Sep 09
PMID:[Autochthonous Plasmodium falciparum malaria and the malarial liver]. 629 Nov 68

Before undertaking a trip to a tropical country, parents frequently ask their pediatrician or general practitioner about the necessary precautions for their child. Although there is no call for excessive concern, it is important to draw the parents' attention to the specific hazards of the trip. To achieve this, one can suggest: 1) before leaving, to ask specialized organizations for information on the specific risks in the areas to be visited according to the conditions of the stay, as well as on health formalities (advisory or compulsory vaccinations); 2) during the stay, to take the necessary precautions (chemoprophylaxy for malaria, precautions concerning food and bathing, treatment of diarrhea); 3) after the return home, to check the child's state of health, to continue giving antimalarials regularly, and to perform the necessary investigations if any symptom persists.
Sem Hop 1983 Feb 24
PMID:[Pediatric advice before departure to tropical countries]. 630 5

Plasmodium falciparum, the main agent of malaria expresses six members of the heat shock protein 70 (Hsp70) family. Hsp70s serve as protein folding facilitators in the cell. Amongst the six Hsp70 species that P. falciparum expresses, Hsp70-x (PfHsp70-x), is partially exported to the host red blood cell where it is implicated in host cell remodeling. Nearly 500 proteins of parasitic origin are exported to the parasite-infected red blood cell (RBC) along with PfHsp70-x. The role of PfHsp70-x in the infected human RBC remains largely unclear. One of the defining features of PfHsp70-x is the presence of EEVN residues at its C-terminus. In this regard, PfHsp70-x resembles canonical eukaryotic cytosol-localized Hsp70s which possess EEVD residues at their C-termini in place of the EEVN residues associated with PfHsp70-x. The EEVD residues of eukaryotic Hsp70s facilitate their interaction with co-chaperones. Characterization of the role of the EEVN residues of PfHsp70-x could provide insights into the function of this protein. In the current study, we expressed and purified recombinant PfHsp70-x (full length) and its EEVN minus form (PfHsp70-xT ). We then conducted structure- function assays towards establishing the role of the EEVN motif of PfHsp70-x. Our findings suggest that the EEVN residues of PfHsp70-x are important for its ATPase activity and chaperone function. Furthermore, the EEVN residues are crucial for the direct interaction between PfHsp70-x and human Hsp70-Hsp90 organizing protein (hHop) in vitro. Hop facilitates functional cooperation between Hsp70 and Hsp90. However, it remains to be established if PfHsp70-x and hHsp90 cooperate in vivo.
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PMID:Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif. 3018 10